2E11,2E11


Conserved Protein Domain Family
Xc-1258_like

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cd07575: Xc-1258_like 
Click on image for an interactive view with Cn3D
Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases)
Uncharacterized subgroup belonging to a larger nitrilase superfamily comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13), class 13 represents proteins that at the time were difficult to place in a distinct similarity group; this subgroup either represents a new class or one that was included previously in class 13. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer. XC1258 is a homotetramer.
Statistics
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PSSM-Id: 143599
View PSSM: cd07575
Aligned: 48 rows
Threshold Bit Score: 391.902
Threshold Setting Gi: 67481589
Created: 21-Apr-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:putative active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                #     #                                 
2E11_A         4 LRISLVQGStrWHDPAGNRDYYGALLEPLag-qSDLVILPETFTSGFSNEAIDkAEdm-dGPTVAWIRTQAARLGAAITG 81  Xanthomonas cam...
ZP_03850929    1 MKVAGLNLDiiWKNKTENFKLIENELQHVe---ADLFLLPEMFSTGFCMDAAEvSDr--nDETLEFLKKISKEKNAAFCG 75  Chryseobacteriu...
ZP_02425655    3 LKVALCQFDmvWEDTAANLRTAGRMVAEAd---ADLVILPEMFATGFVTDPGRvAQpm-sGEIVQEMTRWVRTTGKAVAG 78  Alistipes putre...
NP_905519     10 LRVAVAQCRidWEDKHANLRRMERLAEETag-mADVLFFPEMMTTGFSMNVQAlAEpfeeGETIMSLKRVTARHGLALSA 88  Porphyromonas g...
YP_001678029   4 LKVSVIQSDivWDNKQANYKAIENKITNIdk-qTDLVVLCEMFNTGFIMNPTNeASs--eEDIIIWMHNQVKDKNYAIVG 80  Francisella phi...
ZP_03008453   14 IKVTVLQTDivWEEAKVNRMAVEQLIEKHc--dTDLFVLPEMFSTGFSMNPMEiAEde-gGETLQWMCRIAALRQCAIAG 90  Bacteroides cop...
EEO61486       1 MKITILQRNieWANPQANVARADEAISCLp--dADLFVLPEMFSTGFCTQPEGiAEsa-nSETLHWMKRKAAERNCAIAG 77  Bacteroides sp....
ZP_04389096    6 LTLALAQCDivWENPTENLQVMRETFAQAaqggAEIVVFPEVMTTGFSMHLEAiAEpfesSPSLQSIRAMVQQYGVAVVS 85  Porphyromonas e...
ZP_04055630    6 LRVVLAQRPivWTDPEANLRLMAEDVRTAteegAHLVVFPEVMLTGFNLKVAQsARpw-rGPELERLRALAQEHQIAIAS 84  Porphyromonas u...
YP_002309337   6 LRISIIQLEiiWEDKEKNIKNYQSFISQLkg-kSDLVVLPEMFATGFSVSAKHlPEtn-tDKIMQTILSWSRVFDLAISS 83  Candidatus Azob...
Feature 1                                       #   #    #                        ## ##          
2E11_A        82 SVQLRt----EHGVFNRLLWATPDGaLQYYDKRHLFrFGNEHLRYAAGRERLCVEWKGWRINPQVCYDLRFPVFCRNRFd 157 Xanthomonas cam...
ZP_03850929   76 SAPVEq----GGNFYNRMYFVKPDGdISFYDKRHLFsFSGEDKVYTPGNERVIVEYHGIRFLLQVCYDLRFPVFARNNDd 151 Chryseobacteriu...
ZP_02425655   79 SLIVEe----EGRYYNRLLFIKPSGeRVQSDKRHLFsIGGEGANFCPGRERGVVEYGGIRFLLQVCYDLRFPVWSRCRNd 154 Alistipes putre...
NP_905519     89 TMAVRe----NGKFYNRAYFVTPEGeVFHQDKRHLFrVGGEHEVMTPAQERRIFNYRGWKIFIIPCYDLRFPVWCTNTDl 164 Porphyromonas g...
YP_001678029  81 SAATFt----ENKIANRLYFVTPDKqVYTYDKNHLFiHAGEDKKYTNGNKRQIINYKGFNILLTICFDLRFPVFNCNNNe 156 Francisella phi...
ZP_03008453   91 SLSVRe----AGKFYNRFYFVCPDGtVYHYDKRHLFgFGGEDKQYTSGDERVIVSYKGFRFLLQICYDLRFPVWSRCRNd 166 Bacteroides cop...
EEO61486      78 SVAVCe----NGNYYNRFYFVHPDGaVQHYDKKHLFtFGGEHKRFTAGTERVVVNFRGVRILLEVCYDLRFPVWARNLGd 153 Bacteroides sp....
ZP_04389096   86 SLLVKe----GDKYFNRIFFITPEGeEFFQDKRHLFrMGGEAKQVSPAGGRHVFLYRGWNILLIACYDMRFPVWCRNRAn 161 Porphyromonas e...
ZP_04055630   85 SAFVWddeaqPTHYYNRAYIALPDGsLYAQDKRHLFsMAGEDRLLTPGEGYDIVTYRGWRIRLITCYDLRFPVWCRNRTh 164 Porphyromonas u...
YP_002309337  84 SFLAKd---kDGNLFNRGFFATPEGkIHFSDKRHLFrMSEEIHLFNPGENYNIIPYKNWNIRLIICYDLRFPVWTRNKNn 160 Candidatus Azob...
Feature 1                        ##                                                              
2E11_A       158 verpgqldFDLQLFVANWPsARAYAWKTLLRARAIENLCFVAAVNRVGVDGnQLHYAGDSAVIDFLGQPQVEIReq-eQV 236 Xanthomonas cam...
ZP_03850929  152 --------YDAVLYVANWPeKRVGAWEHLLKARAIENLSFVFGLNRIGTDGnNLFYQESSHCFFADGKEISRKQg---NL 220 Chryseobacteriu...
ZP_02425655  155 --------YDAIIYVASWPaGRRDVWRTLLRARAIENQAYVLGVNRTGDDP-RLHYSGDSAVIGCKGETLAEAGeg-eTL 224 Alistipes putre...
NP_905519    165 -------eYDLLVCMANWPePRRAVWQTLLQARAMENYAYVCGINRVGEDGiGLRYTGDSAILSPRGEYLATCAegeeKV 237 Porphyromonas g...
YP_001678029 157 --------YDVLLNVACWPeSRREHWKSLLKARAIENQAYVIACNRVGNDP-NFSYSGDSLIIDYNGDVLAHEEyk-eTI 226 Francisella phi...
ZP_03008453  167 --------YDAVIYVANWPaSRREVWNILLKARALENQCYVIGVNRVGNDP-QCLYDGGSMIISPYGKILVACTdgkeEV 237 Bacteroides cop...
EEO61486     154 --------YDMILYVASWPtPRVDAWSALLRVRAIENQCYVAGVNRMGVDP-ACEYSGGSAIIDPYGKTIAECPwsreSA 224 Bacteroides sp....
ZP_04389096  162 -------eYDLLIDVANWPePRRLVWSTLLRARAMENLAYVCGVNRVGRDAeGLVYTGDSALIDPKGRELAALEerriEL 234 Porphyromonas e...
ZP_04055630  165 tdg--sldYDLLLVVANWPrPRITAWRTLLQARAIENVAYVIGVNRIGSDPfGTDYSGESLAYDYLGSPLIEAEpyadQL 242 Porphyromonas u...
YP_002309337 161 -------eYDLLLCVANWPkTRSNSWEILLKARSIENLCYTCGVNRIGHDGnNISYQGGSMLLNFKGEIILEAGkdqeSA 233 Candidatus Azob...
Feature 1                                   
2E11_A       237 VTTTISAAALAEHRARFPAMLDGDSFV 263 Xanthomonas campestris pv. campestris str. B100
ZP_03850929  221 VSAELNMNELKDFRTHFQFLNDRDSFS 247 Chryseobacterium gleum ATCC 35910
ZP_02425655  225 LTARLDMDELRRFREKFPAWRDADDFD 251 Alistipes putredinis DSM 17216
NP_905519    238 LYHTLDKGAMQRFRDKFPAWMDMDSFV 264 Porphyromonas gingivalis W83
YP_001678029 227 LTATIDKNKQQEHRNKFNFLASQDNFT 253 Francisella philomiragia subsp. philomiragia ATCC 25017
ZP_03008453  238 AGALLAREPLDSFRKRFPVLDDGDDFE 264 Bacteroides coprocola DSM 17136
EEO61486     225 VSADIDMEALQTFRKKFPVLDDADPFT 251 Bacteroides sp. 9_1_42FAA
ZP_04389096  235 KIATLERAPLDKLRKKFPVYLDADEFS 261 Porphyromonas endodontalis ATCC 35406
ZP_04055630  243 LSATLEPEPLAAFRQKFPVWRDSDSFT 269 Porphyromonas uenonis 60-3
YP_002309337 234 LTTTIYKEKLQDFRNKFPIWKDADSFN 260 Candidatus Azobacteroides pseudotrichonymphae genomovar. CFP2

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