Conserved Protein Domain Family
nitrilase_Rim1_like

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cd07574: nitrilase_Rim1_like 
Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases)
Some members of this subgroup are implicated in post-translational modification, as they contain an N-terminal GCN5-related N-acetyltransferase (GNAT) protein RimI family domain. The nitrilase superfamily is comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13), this subgroup corresponds to class 12. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer.
Statistics
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PSSM-Id: 143598
View PSSM: cd07574
Aligned: 40 rows
Threshold Bit Score: 300.657
Threshold Setting Gi: 220931590
Created: 21-Apr-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:putative active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                 #                                      
NP_462048      5 FTVSACQYIVTeinTFEDFITKVRILLNKSQg--ADVVIFPELFTIELFTllkkwqer-------------pishltlID 69  Salmonella typh...
YP_002247627  39 NIVAAFNTNLRfydNALEFAHSVASYMTAALdkgAGVILFPEYFGNLLMGiagepidldd--------pstlellsmiSP 110 Coprothermobact...
ZP_03728246   44 IPVGAVQLEVKltdNAGEYMDEMCRITNKAArqgVRLLAFPEYSTFPLLGyipgieklaegtatdnqevsvadlfrfaGP 123 Dethiobacter al...
ZP_02463421    5 LKVSIASFGTRryaLLHDFTTHVEELASQAQatgSEVLLLPELTSTGLLWthpeaadvtt--------ktvsefyrrvLT 76  Burkholderia th...
ZP_00952766  226 VRVAAIQMAMRsmeTLKEFERNVEYFVEVCSdyrADFCVFPEMFTVALLAlekrklt--------------peesiaaLS 291 Oceanicaulis al...
ZP_01892353  198 VRIGTVQYQQRrvaSFEEFSDIVRYFVDVVStykGDFVVFPELFTLQLLSiesrdgt--------------paeaieaVT 263 Marinobacter al...
YP_002315676   3 MRVSAVQYHLHtiqSFEQFAKQVEHYVKTAQefgAEFVLFPEFMTTQLMSigddtke---------------altideLP 67  Anoxybacillus f...
ZP_01665814    3 LRVSAVQYHLHtikSFAEFAQQVEHYVKTAAefeADFVLFPEFVTTQLLSigdshgn---------------alsihnLP 67  Thermosinus car...
YP_001529209 229 IRMCAAQYAMRpirSWEEMEESVEFFVSFADsyhCHFLVLPEYMTYQMFScmqgaem---------------kqlvadLA 293 Desulfococcus o...
YP_003060655 230 VRVCSVQFQMRkvnSFEEFMGQVEYFVDVASdyrSDFVCFPEFLTMPLISlskdqts--------------ssenieyLT 295 Hirschia baltic...
Feature 1                                                             #   #    #                 
NP_462048     70 QFTDAYKQLFQQEAKERGQFIIaGSHLEqtgADRYENVAHIWGPDGEH-YAHSKTHIFp-aERGWYTQEGDKMAVFQLPf 147 Salmonella typh...
YP_002247627 111 ILYSTYVDIFSQISAKTDATIVaGTLAFv-eNGKLVNRTFVFRRGNVI-LTQDKAHLMp-mEEKWGMSRGSRLGLFDLGt 187 Coprothermobact...
ZP_03728246  124 FFNRVAHFTFSKLASTFGLYIMsGSMPYp-vEDRVVNRAFLYGPDGQIlGHQDKVHLMp-mEHAWGFSAGDAFNVFDTPl 201 Dethiobacter al...
ZP_02463421   77 PLVGEYCETLQTLAKKHGIAIA-GASFWheeDGVGRNSGWVFKPDGSV-ERQDKLHMTr-gERAISTSGGDSLTTFEIGg 153 Burkholderia th...
ZP_00952766  292 RHTPRFIELMSTLAVRYNINIVgGSHPTrtdDGDIQNVAYVFLRDGSV-HAQEKIHPTpneRYWWNIKGGDAVATIPTDc 370 Oceanicaulis al...
ZP_01892353  264 EYAEPFRNLMRDLALRHNINIVgGSTPVkeeDGRVRNVAYVFLRDGQV-FSQPKIHPTpneAYWWNITGGSRVTAIETDc 342 Marinobacter al...
YP_002315676  68 TFTEAYRSLFSTLAKQTNMHIIgGTHVIk-rEDRLYNVAHLFYPDGTI-AEQAKLHITpteVNEWNMHGGDTLHVFDTIk 145 Anoxybacillus f...
ZP_01665814   68 DFTEQYCLLFTSLAQQTGMHIIgGTHVIr-eDERLYNVAHLFYPNGKI-VRQPKLHITpteVKEWNMAAGHDINVFETEk 145 Thermosinus car...
YP_001529209 294 DMTDRYVEMFKQFAKRYRIYIIgGSTPVr-rDGRLYNTAHLFTPGGQV-HTQDKLHITpaeRAESEIEPGSHIRLFQTPl 371 Desulfococcus o...
YP_003060655 296 TLTDAFVEAMSEMAISYNINIIgGTHPTrveSGEIYNMAFVFLRDGSI-HTQPKIHITpseQYWCNIHGGNSLAAIETDc 374 Hirschia baltic...
Feature 1               ## ##                    #                                               
NP_462048    148 AKVGFNICYEAEIPECAATLAeqGVELILTPSATFTeqGFWRVRHCCHARCIENQIYLVHCCLGGNPGg---pLPGCWAR 224 Salmonella typh...
YP_002247627 188 QKAGVLVCMDATYYEQSRILEnmGARLLLVPSANPApfYLGEQIRGAWARAQTSQVFTVQSFLVGKLG-----DYVFEGK 262 Coprothermobact...
ZP_03728246  202 GKLAMPVCMDATYFETFRILErqGAEIVMVPIANAEeyNYWLALRGIWPRVQESMVYGIKSALVGQVL-----GHTLTGK 276 Dethiobacter al...
ZP_02463421  154 VKCGLFVCYDVQFPELTQYLVgqGVEVLLVPSLTEEr-GAWRVWHSAHARALENQLFVCVSTLVGPLDipndyQSVASGR 232 Burkholderia th...
ZP_00952766  371 GPVGVLICYDTEFPELARRLAdeGAKIIFAPYATDDrgGHLRVRYCAHARAIENQLYVVTAGNVGNLPgv-enMDINYAQ 449 Oceanicaulis al...
ZP_01892353  343 GPIGVLVCYDAEFPELTRHLVdqGIQILFVPFCTDErqSYLRVRYCCQARAVENQLFVIMSGNVGNLPkv-pnMELQYGQ 421 Marinobacter al...
YP_002315676 146 GTIAILTCYDIEFPEIVRMARakGADVIFCPSCTDDrhGFHRVRYTCHARAIENQVYVVTTGTVGSLPtv-dfMRANFGQ 224 Anoxybacillus f...
ZP_01665814  146 GTIAILTCYDIEFPEIVRMVRakGADVIFCPSCTDDrhGFYRVRYTSHARAIENQVYVVTTGTVGSLPtv-dfMRANFGQ 224 Thermosinus car...
YP_001529209 372 ARIGIQICYDIEFPEVSRLLTlaGAEVIVVPFYTEEkkAYYRVRHCAQARAVENFIYVVMAGSVGNMRtp-igSFMHYSQ 450 Desulfococcus o...
YP_003060655 375 GTIGVNVCYDSEFPELARNLTdqGINILFVPFSTDDrqGYNRVRYCSAARAIENQIYVVMAGTVGNMPnv-knMDINYAE 453 Hirschia baltic...
Feature 1                                                                  
NP_462048    225 SSILSPCDVVWKnpQGIIAEAHVNq-EDVISGEINLDVLYENRLggaattfKDRRRKA 281 Salmonella typhimurium LT2
YP_002247627 263 AGVYAPHDYTEDl-SGIVALSKKYnqEELVTAVLDYERLNRVRQp------RDFRFQA 313 Coprothermobacter proteolyticus DSM 5265
ZP_03728246  277 AGIFAPLELTPNq-DGTLAEAKTFdsQELVTATLDLEALHNLRAthp--ylGDQNPAL 331 Dethiobacter alkaliphilus AHT 1
ZP_02463421  233 AFVACPIDNRFKvvDGTYALGAEG--EYLLNTSLDLETLRMSREksevrqlADRRPAL 288 Burkholderia thailandensis MSMB43
ZP_00952766  450 SAILTPCDFPFAr-DGIAAETSENv-ETIAVADLHLDDLVQARRsgtvrnlRDRRFDL 505 Oceanicaulis alexandrii HTCC2633
ZP_01892353  422 SCILTPCDFPFAr-DGIAADTTPNv-ETVAFADLRPETLLTARNsgtvknlKDRRHDL 477 Marinobacter algicola DG893
YP_002315676 225 AAIITPNDIPFPp-RGILAEGEINd-DMIITADIDLQLLYDVRKrgsvttwRDRRTDL 280 Anoxybacillus flavithermus WK1
ZP_01665814  225 AAVITPNDIPFPp-GGLLAEGEINh-DMIITADLDLELLYRVRErgsvttwRDRRTDL 280 Thermosinus carboxydivorans Nor1
YP_001529209 451 SAILSPSDFSFPe-KGIEGEADPNa-EAAVVSELTLSALAEQRHvatvrplHDRRADL 506 Desulfococcus oleovorans Hxd3
YP_003060655 454 SCILTPCDFPFAr-DGIAATSAPNt-EMVVMSDLNIETLIASRKsgtvqnlKDRRLDL 509 Hirschia baltica ATCC 49814

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