Conserved Protein Domain Family
ALP_N-acyl_transferase

?
cd07571: ALP_N-acyl_transferase 
Apolipoprotein N-acyl transferase (class 9 nitrilases)
ALP N-acyl transferase (Lnt), is an essential membrane-bound enzyme in gram-negative bacteria, which catalyzes the N-acylation of apolipoproteins, the final step in lipoprotein maturation. This is a reverse amidase (i.e. condensation) reaction. This subgroup belongs to a larger nitrilase superfamily comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13), this subgroup corresponds to class 9.
Statistics
?
PSSM-Id: 143595
View PSSM: cd07571
Aligned: 297 rows
Threshold Bit Score: 164.309
Threshold Setting Gi: 33861848
Created: 21-Apr-2009
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
 
Feature 1:putative active site [active site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                 #                      
P23930       222 IQVSMVQGDIPQslk------wdEGQLLNTLKIYYNATapl------mgkSSLIIWPESAITdleinqQPFLKALDGELr 289 Escherichia col...
ZP_01124649  223 LNLALWQPAIPTrekf---saerQRQFPRLLRAALTRAea--------dgADLLIAPEGTLPl----dRGNLLAEPVPL- 286 Synechococcus s...
YP_729972    201 YSVGLWQPAIPTrekf---saqrQRDLPLRLQAALQEAea--------adADWLMAPEGTLSf----hDSLIAPAPIPL- 264 Synechococcus s...
YP_001551224 227 KAVAIWQSAIPTrekf---sidqLRRLPFSLEQALKEAnv--------lgASFMVAPEGTLPi----gQELLSPAQIPL- 290 Prochlorococcus...
YP_001228043 227 LSLVVAQPNLPTrekfsaeqqqrQRQLLMKAMAAAEQQg-----------ADAVVLPEGALPl-----GQALPAMPVAL- 289 Synechococcus s...
YP_381199    218 VALGVWQPAVPT-----------REKFDLERQQALPMAlvdamrqlepnnPAAVVAPEGALP------ARFQLPAEAPAm 280 Synechococcus s...
NP_875757    230 KRIALWQTNIPTrqkf---tlreLKRLPISLQDALEEAdn--------lgADWMVAPEGTLSa----gQNLLAPSPLPL- 293 Prochlorococcus...
YP_292053    226 EKVAMWQTNIPIrqkf---sqeeINALPSKVNRALTEAfe--------mnASFLIAPEGTLPl----dRSKIRDFSIKF- 289 Prochlorococcus...
NP_893409    231 YPVALWQTNMPTrekt----nfkNQFINDKLISAQKIAls--------ndAKLLITPEGTLN------NNFNLNFKSKIr 292 Prochlorococcus...
ZP_01084000  221 FRVLVLQPALPTrekf---epdrQRDLLLQIARARQQAat---------lGVPLLLPEGTLVl-----GQAMPEAEAEV- 282 Synechococcus s...
Feature 1                                                     #   #   #                          
P23930       290 dkGSSLVTGIVDArlnkqnrydtYNTIITLGKGApysyesaDRYNKNHLVPFGEFVPLESILrplapffdlpmssFSRGP 369 Escherichia col...
ZP_01124649  287 --ISGGFRWVTGRq---------RSALLLLQGDDat---paAVIDKHRLVPLGEWTPALPGLagls-----avggLEPGG 347 Synechococcus s...
YP_729972    265 --MSGGFRWSRGRq---------HSAMVLVEAGGtt---pvASIDKHRLVPLGEWVPALPGLsgls-----aiggLEAGE 325 Synechococcus s...
YP_001551224 291 --LSGGFRADKGNq---------RSSLLVFKKDQtt---ftDFVDKYRLVPLGEWIPPLPGLsipgl---ssiggIEPGE 353 Prochlorococcus...
YP_001228043 290 --LSGGFRRQELDe---------RSSVLWFPAGStr---pqQWLDKQRLVPLGEWVPGGLAGlsa-------vggVSPGE 348 Synechococcus s...
YP_381199    281 plISGGFRWVRGQq---------RSSLLLYEPPDwf---pvPLADKHRLVPIGEWIPPLPAGltagl---savggLSPGP 345 Synechococcus s...
NP_875757    294 --LSGGFRRVKNKq---------MSSLLVFNEGSts---ysSAIDKHRLVPLGEWLPSLPGVnwngl---sfvggVDPGD 356 Prochlorococcus...
YP_292053    290 --LSGGFRKINGSi---------RSSLLVFNPGEes---fsDVLDKSRLVPLGEWIPELPNFlkdgl---savggIESGN 352 Prochlorococcus...
NP_893409    293 -mLAGGFRNSKNGl---------RSSLLGYQIGDkt---ysSFIDKHRLVPLGEKIPGFLNIfsrgl---savggIQPGS 356 Prochlorococcus...
ZP_01084000  283 --LSGGFRLEGEEl---------RSSVLRFAPSAse---asGWVDKARVVPLGEWVPLARLWrwggl---savggVEPGP 345 Synechococcus s...
Feature 1                          ## ##                    #                                    
P23930       370 yiqPPLSAng-iELTAAICYEIILGEqVRDNFrpdTDYLLTISNDAWFGKSiGPWQHFQMARMRALELARPLLRSTNNGI 448 Escherichia col...
ZP_01124649  348 asrLWRWGg--pPAQVAICYEISNGTaLARAAaggGQWILTAANLDPYPLL-LQHQFLALAQLRSVETARPLVSAANTGP 424 Synechococcus s...
YP_729972    326 psrLWRWGg--pPASVAICYEISNGAaLARAVaegAEWILAAANLDPYPRL-LQMQYLALAQLRSLETARPLLSTANTGP 402 Synechococcus s...
YP_001551224 354 ssrLLIWDg--pPIAVAICYEITNGNgLSKAVkdgAQWILAIANLDPYPIS-LQKQFLALAQMRSIESARDLITVSNTGP 430 Prochlorococcus...
YP_001228043 349 aprLLALPpplgPVAVAICYELSDGLgLNQAVrdgAGWLLAIANLDPYPLA-LQQQFTALAQLRAIETSRWLLSSANTGP 427 Synechococcus s...
YP_381199    346 aprTMAVVe--pPAAVAICYEIADGLaLARAAadgATWLLAIANLDPYPLQ-LQEQFLALAQLRAIETGRDLLSVGNTGP 422 Synechococcus s...
NP_875757    357 asrFFDWDg--gPLAVAICYELSDGNnLAKAIfdgAEWILAIANLDPYPIS-LQRQFLALAQLRSIESARNLISVANTGP 433 Prochlorococcus...
YP_292053    353 psrLLDWEg--pSFAGAICYELSNGKaIAKAVnqgAKWILVIANLDPYPIS-LQKQFLSIAQLRSIETSKNLISVSNTGP 429 Prochlorococcus...
NP_893409    357 dsrFFKWKft-qPLAIAICYEITDGFkIRNAVksgAELIISAANLDPYPRK-LHYQFLSLARVRSIENKKDNIIISNTGP 434 Prochlorococcus...
ZP_01084000  346 psrLLRRSg--aDPAVAICYELANGEgLREATvagAGWLLASANLDPYPAL-LRDQFTALAQLRAIEVGRWLVSTANTGP 422 Synechococcus s...
Feature 1                                                         
P23930       449 TAVIGPqGEIQAMIPqftrEVLTTNVTPTtgLTPYARtGNWPLWVLTAL 497 Escherichia coli K12
ZP_01124649  425 TAAINAhGQVTSRLTamrpGVLTVQVQPStvMTTYARlREWPLVGLLLI 473 Synechococcus sp. WH 7805
YP_729972    403 TAMIRAdGQIADRLAsfdpGLLVVPFQPRtgLTGYVRwGELPLLLLIGA 451 Synechococcus sp. CC9311
YP_001551224 431 STMISAdGSITPVIPpfkqKVGLASLHFSekITPYVRwGEKPLIVFLIA 479 Prochlorococcus marinus str. MIT 9211
YP_001228043 428 SALISPrGELHQQLPanqeSLGLMQVPTLssESLLTRwGVWPQWLLWLG 476 Synechococcus sp. RCC307
YP_381199    423 TALISAnGSVQRLLApeasGVAEAVVQVRqrVTPYSRwISPPPRTVSPS 471 Synechococcus sp. CC9605
NP_875757    434 TSMILSsGKIKSIIEpfneGVGVIDINVSqkISGYVRwGEIPLISSLLI 482 Prochlorococcus marinus subsp. marinus str. CC...
YP_292053    430 TSLIKSnGRIDTLLKpneeLVQLADLELNgkKTLYTLiSDLPMIVVILI 478 Prochlorococcus marinus str. NATL2A
NP_893409    435 SGLISEeGKIIKLFDpnteQNDVVNPNFSieKTFYTTyGERPLFLLCLF 483 Prochlorococcus marinus subsp. pastoris str. C...
ZP_01084000  423 SLVIDGrGVVRAALPpghpELGVFELERLkrSTTYQIwREAPLILMILL 471 Synechococcus sp. WH 5701

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap