Conserved Protein Domain Family
biotinidase_like

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cd07567: biotinidase_like 
biotinidase and vanins (class 4 nitrilases)
These secondary amidases participate in vitamin recycling. Biotinidase (EC 3.5.1.12) has both a hydrolase and a transferase activity. It hydrolyzes free biocytin or small biotinyl-peptides produced during the proteolytic degradation of biotin-dependent carboxylases, to release free biotin (vitamin H), and it can transfer biotin to acceptor molecules such as histones. Biotinidase deficiency in humans is an autosomal recessive disorder characterized by neurological and cutaneous symptoms. This subgroup includes the three human vanins, vanin1-3. Vanins are ectoenzymes, Vanin-1, and -2 are membrane associated, vanin-3 is secreted. They are pantotheinases (EC 3.5.1.92, pantetheine hydrolase), which convert pantetheine, to pantothenic acid (vitamin B5) and cysteamine (2-aminoethanethiol, a potent anti-oxidant). They are potential targets for therapeutic intervention in inflammatory disorders. Vanin-1 deficient mice lacking free cysteamine are less susceptible to intestinal inflammation, and expression of vanin-1 and -3 is induced as part of the inflammatory-regenerative differentiation program of human epidermis. This subgroup belongs to a larger nitrilase superfamily comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13), this subgroup corresponds to class 4. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer.
Statistics
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PSSM-Id: 143591
View PSSM: cd07567
Aligned: 33 rows
Threshold Bit Score: 344.998
Threshold Setting Gi: 66814826
Created: 21-Apr-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:putative active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                              #                         
NP_001034377  26 FIAAVYEHAVilprtihkvspadalalMNRNMDVLEGAVKEAAQq-gARIIVTPEDGIYGwvftretiypyledipdpev 104 chicken
Q8IRR1        33 YTAGVVEFEPsn--------------eLSDNLAGYLEIIQSQNAt-sTDIIVFPESTLNSagsttfvpnpedq------- 90  fruit fly
XP_001657370  29 YWAGVVEFSFkersmnn----esglisTPKNLEKYKEIINSPEAd-pLDIIVFPEYGLSQvetasfvpnpe--------- 94  yellow fever mo...
NP_727067     29 YIAGVVEYRPtfmgg-------tseqlLQANLAGYLEIMASGNGt--TDIIVFPEATLNSvitltavpkfteq------- 92  fruit fly
XP_001650807  30 YVVGVVEFRPellnm-------diagrTAKHLKKYKKLLRSKDAk-lTDIVVFPELTLNTlmdpvpvpdps--------- 92  yellow fever mo...
XP_320200     39 YVVSVVEFHPepmtm-------pieqrTQLHLAEYSRLIRSPEAk-pADIIVFPELTLNSlsdtvfvpdp---------- 100 Anopheles gambi...
XP_001657369  37 YVVGVVEFCPepsdv-------dvrsrTERHLEAYAKLIRSDEAk-vTDIIIFPELTLNTfsdsvyvpdps--------- 99  yellow fever mo...
XP_970529     23 VTIAVVEYKPildssl------nepeiVAKNAQKYIEIITNVAKdrnLDLIVFPEETLYVhretavtikl---------- 86  red flour beetle
XP_967970     25 ANIAVIEYQPfvdkrl------teeqiVLENTKKYLEIIKTLVKtenFDMIIFPESTLKTspktsveini---------- 88  red flour beetle
XP_001947951  34 YIAAVVEYHPilgsn--------plqsMQNNLPIYEDIIHHASQy-dVDILVFPEAGLTGvtlpdnrkeiktflte-ips 103 pea aphid
Feature 1                                                                                     #  
NP_001034377 105 nwipctdptrfgrTPVQERLSCMARNNSIYVVANIGDKKPCnssd----pkcPSDGRYQYNTDVVFDSEGKLVARYHKYN 180 chicken
Q8IRR1        91 inpclsdpnatyyEEFLVTLSCAARNASKYIVINLTEKQKCedipe-dtrpcASNGLNVFNTNVVFDRQGVVVSRYRKVH 169 fruit fly
XP_001657370  95 --dlitpcnnldyEPVVRDLSCMARARQKYLVVNLVEKAFCpekdd--wrpcAPNGLYHFNANVVFDRHGRVIARYRKFN 170 yellow fever mo...
NP_727067     93 slceeqgdddpeiAPFLRSLACAAREYGTYLVVNVKERVSEqcts---detcSSRGYSIHNTNVVFDRQGAVISRYRKWN 169 fruit fly
XP_001650807  93 ---dsiipcvpnsSELISRLSCLAIDTGKYIVINLSESFECdslpvhdprpcDPSVPHRYNTNVVFDRNGTVIARYRKTH 169 yellow fever mo...
XP_320200    101 ---aqrvapcddhGTILVTLSCLAREVRKYLVINLSEQFYLq----------QQAETVRYNTDVVFDRTGTVIARYRKYN 167 Anopheles gambi...
XP_001657369 100 --tnvipceenssRNVLPFLSCLAAEVEKYLVINLSEIFDCks--------cAPHGYVWYNTNVVFDRNGAVIARYRKFN 169 yellow fever mo...
XP_970529     87 ----dnpcdsdtyPQFLRNLSCAARSSHTYLALNLVDKVKCdqsqtnsskncKNSGFFYYNTDVVFDRNGTIVNRYHKYN 162 red flour beetle
XP_967970     89 ---mdnpcdsltyPEFMKNLSCAARNSNTYLVINLVEKVKCdrt------ncKNSGFFFYNTDVIIDRTGKITNTYHKYN 159 red flour beetle
XP_001947951 104 pesntipcftkycSTVLNKLSCAARLHHMYVVVNLPEIEYCkted---ddscPEDLANYYNTNVVFNREGRIVARYRKFN 180 pea aphid
Feature 1         #  #                          ## ##                     #                      
NP_001034377 181 LFrQETQFNYPKEPefITFETPFG-KFGVFTCFDILFREPAVVLASElQVDTVLFPTAWMNvLPFLTAVEFHSAWAMGMG 259 chicken
Q8IRR1       170 LY-GEPKNSTFLPEl-STFETDFGvTFGHFICFDILFYTPAHQLIVEqGITDFVYPAMWFSqLPFLTAVQIQLGWSYANN 247 fruit fly
XP_001657370 171 LF-GEPGINITRWSdiTTFDTDFGvTFGTFICFDLMFDEPALQLVRQ-GITDFIFPTMWFSeLPFLTAAQIQQSWAYANN 248 yellow fever mo...
NP_727067    170 LY-LEPSTNRTESPeiATFTTDFNvTFGHFICFDMLFYTPAQDLVEQlGIRHVIVTKMFNSeLPFLTASQFQQGWAWANR 248 fruit fly
XP_001650807 170 LF-REPGTSVTYQPevVTFDTDFGvRFGVVTCFDLLFAEPTLELVKL-GVRDFVFPAMWVSePPFLTAVQIFESWAYGND 247 yellow fever mo...
XP_320200    168 LF-KEPGTSVTAAPelVSFETDFGvHFGVFTCFDILFAQPTLELVKH-GLRDFVFPAFWTSePPFLSSTQIFESWAYAND 245 Anopheles gambi...
XP_001657369 170 LL-GEHGTERTYVPeiVTFETDFGvTFGLFTRSDVLFARPALELIKR-DVKDLIMPSMWQAeLPYLTSTQVYESWAYSNN 247 yellow fever mo...
XP_970529    163 LF-GEREMDKPETAeeIVIETDFGlKLGIFTCFDILFKAPAQELLKD-GIDGAIYPSMWYSeLPFLTAMQTQEMWASRHN 240 red flour beetle
XP_967970    160 LF-GEHDLDKPKVEk-VVIYTDFGvKFGIFTCFDILFKSPALDLVKE-DIDGVIFPSNWYSeLPFLTSLQTQQMWAYNYD 236 red flour beetle
XP_001947951 181 LF-GELGFNHTSSSelCTFDTDFGvRFGMFICFDILFQDPAARLIREtGVKDIIFSTAWFSeIPLLTADSVQAGWAYTND 259 pea aphid
Feature 1                                                                                     
NP_001034377 260 VNLLSANTHNTIMSmTGSGLFTPH-GPALYYYNSKt--eEGRLLVAELNARPRLSPNypaavn----wssyaTSVKN 329 chicken
Q8IRR1       248 VNLLAAGASDPIVGnSGSGIYHGRsGSLRSVMRQEs--gERSIYVARVPKYRAKRRMkrdlkrq-vatsssfNIKRD 321 fruit fly
XP_001657370 249 VNFLAAGSSFPEIGsTGTGVFAGKrGRIVTVMNHNa---DSKLYVAQVPKISRPQATisrqpvi-kysssemSNLKL 321 yellow fever mosquito
NP_727067    249 VNLLASGGSLPQGGiSGSGIYAGQqGALARLMITDelvgQRKLLLAKVPLDPEEPIAtdeile---peimtpVKLKL 322 fruit fly
XP_001650807 248 VNLIAAGTNYDPSGsTGTGVFNGRnGAVFSFITGEs---TRKIFPVRVPKLPSSPSTpldn-------dsetISGRF 314 yellow fever mosquito
XP_320200    246 ANLIVAGTNYGPSGaTGTGVFNGRnGALLTHYTGVp---TRALYTVTVPKSGSGNHTryh---------sltSDVLE 310 Anopheles gambiae ...
XP_001657369 248 VNLIVAGGNNEATGsTGTGVFNGRsGAILSFVTGEp---TRRLFPVRVPINPGIRTAnhipled-sdteagrLHGKF 320 yellow fever mosquito
XP_970529    241 TTLLAAGANSPLVGsGGSGVYRGAqGLVVGGIVAEg---GTQVFVYQGDKSVSETQDvdelak---kmdafnLQIDN 311 red flour beetle
XP_967970    237 VLFFGAGGNYPKVGtGGSGIYNASrGTISQGYVAKg---GSHIFAFRSKNGQVLVPPepnidilakemdefyLATDS 310 red flour beetle
XP_001947951 260 VNLIAASYNAPSMGgGGSGIYAGRdGPLVMFMPDRp---GTQIILSRVLKRQYNNCNiqskkcs-idsnyqtFMSDN 332 pea aphid

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