Conserved Protein Domain Family
ALDH_ACDHII_AcoD-like

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cd07559: ALDH_ACDHII_AcoD-like 
Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II and Staphylococcus aureus AldA1 (SACOL0154)-like
Included in this CD is the NAD+-dependent, acetaldehyde dehydrogenase II (AcDHII, AcoD, EC=1.2.1.3) from Ralstonia (Alcaligenes) eutrophus H16 involved in the catabolism of acetoin and ethanol, and similar proteins, such as, the dimeric dihydrolipoamide dehydrogenase of the acetoin dehydrogenase enzyme system of Klebsiella pneumonia. Also included are sequences similar to the NAD+-dependent chloroacetaldehyde dehydrogenases (AldA and AldB) of Xanthobacter autotrophicus GJ10 which are involved in the degradation of 1,2-dichloroethane, as well as, the uncharacterized aldehyde dehydrogenase from Staphylococcus aureus (AldA1, locus SACOL0154) and other similar sequences.
Statistics
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PSSM-Id: 143471
View PSSM: cd07559
Aligned: 17 rows
Threshold Bit Score: 848.939
Threshold Setting Gi: 81695504
Created: 17-Jun-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:catalytic residues [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
P46368        19 YENYIGGAWVPPaggeYFESTTPITGKPFTRVPRSgqqDVDAALDAAHAAKAAWarTSTTERANILNRIADRIEANLKLL 98  Ralstonia eutro...
Q5HJK3        13 YGLFINGEFVKGssdeTIEVTNPATGETLSHITRAkdkDVDHAVKVAQEAFESWslTSKSERAQMLRDIGDKLMAQKDKI 92  Staphylococcus ...
Q9ZA11        19 YDNFIDGTWQPPvrgeYFDNVTPITGKVFCKAARSteeDITLALDAAHAAADRWgrTTAAERALILNRIADRLQDNLETL 98  Rhodospirillum ...
P63938        20 YQNFIGGQWVAPvhgrYFENPTPVTGQPFCEVPRSdaaDIDKALDAAHAAAPGWgkTAPAERAAILNMIADRIDKNAAAL 99  Mycobacterium t...
YP_001543935  19 YGNYINGEFVEPvkgmYFENISPVNGKPFCEIPRStaeDIEKALDAAHAAKAAWgaTSPAQRANILNKIADRMEANLEML 98  Herpetosiphon a...
Q9RYG9        29 YDNFIGGQWVPPvkgqYFDNASPVDGKVFTQAARStaeDVELALDAAHRAAPAWgrTSVTERSNILLKIADRMEQNLEML 108 Deinococcus rad...
NP_814048     14 YQLYINGEWTTGsgnkMIASYNPSNGEKLAEFVDAtnaDVDRAVEAAQEAFQTWkdVDVVTRSNLLLKIADLIEENQEHL 93  Enterococcus fa...
YP_001558079   9 YKLYINGEWKDAsdgaTIKTYNPSNGEFLAEIADAtnnDVDEAIAAAREAFKTWgkTTPVERAAVLNKIADIIDENAEFL 88  Clostridium phy...
NP_603351      9 YKMFINGEWIDSsngvMVKSYAPYNNELLSEFPDAsesDIDFAIKSAKEAFKTWrkTTVKERARILNKIADIIDENKDLL 88  Fusobacterium n...
YP_001407270   8 YDLFINGEFVKSssneTIDVFNPSNGKMLSTITDAtkeDVDSAVKAARKAFNKFkhSTVNERSIILNKIADIIYENKEFL 87  Campylobacter h...
Feature 1                                                                          #             
P46368        99 AVAESIDNGKPVRETTAADLPLAVDHFRYFAGCIRaqEGGISEIDadTIAYHFHEPLGVVGQIIPWNFPLLMATWKLAPA 178 Ralstonia eutro...
Q5HJK3        93 AMIETLNNGKPIRETTAIDIPFAARHFHYFASVIEteEGTVNDIDkdTMSIVRHEPIGVVGAVVAWNFPMLLAAWKIAPA 172 Staphylococcus ...
Q9ZA11        99 AYVESIDNGKPIRETLAADIPLAIDHFRYFAACIRaqEGSLSQIDetTIAYHFNEPLGVVGQIIPWNFPILMATWKLAPA 178 Rhodospirillum ...
P63938       100 AVAEVWDNGKPVREALAADIPLAVDHFRYFAAAIRaqEGALSQIDedTVAYHFHEPLGVVGQIIPWNFPILMAAWKLAPA 179 Mycobacterium t...
YP_001543935  99 AVAETWENGKPVRETLAADLPLAIDHFRYFAGVIRaqEGSAATIDenTIAYHFYEPLGVVGQIIPWNFPLLMATWKLAPA 178 Herpetosiphon a...
Q9RYG9       109 AVAETWDNGKPVRETLAADLPLAIDHFRYFAGCIRaqEGGLSQIDdsTVAYHFHEPLGVVGQIIPWNFPLLMGVWKLAPA 188 Deinococcus rad...
NP_814048     94 AMVETLDNGKPLRETQSIDVPASADHFRYFASVIRgeEGSVKEFDkdTLSIVVKEPIGVVGQIIPWNFPLLMGAWKLAPA 173 Enterococcus fa...
YP_001558079  89 ATVETMDNGKPIRETTGADIPLAADHFRYFAGVIRaeEGTSTMIDenTLNLILREPIGVVGQIVPWNFPFLMAAWKLAPV 168 Clostridium phy...
NP_603351     89 ATVETMDNGKPIRETKLVDIPLAATHFRYFAGCILadEGQATVLDekFLSLILREPIGVVGQIIPWNFPFLMAAWKLAPA 168 Fusobacterium n...
YP_001407270  88 AKVETMDNGKPIRETLNVDIPYAAEHFRYFAGVILgeEGSANVLNeqLLSVVLREPIGVVGQIVPWNFPFLMAAWKLAPV 167 Campylobacter h...
Feature 1                                                                                        
P46368       179 LAAGNCVVLKPAEqTPASILVLMEVIGdLLPPGVVNVINGFGleaGKPLASSPrISKVAFTGETTTGRLIMQYASqnLIP 258 Ralstonia eutro...
Q5HJK3       173 IAAGNTIVIQPSSsTPLSLLEVAKIFQeVLPKGVVNILTGKGsesGNAIFNHDgVDKLSFTGSTDVGYQVAEAAAkhLVP 252 Staphylococcus ...
Q9ZA11       179 LAAGNCIVLKPAEqTPISILVLTELIAdLLPPGVLNVVNGFGleaGKPLASSKrIAKIAFTGETATGRLIMQYASqnLIP 258 Rhodospirillum ...
P63938       180 LAAGNTAVLKPAEqTPASVLYLMSLIGdLLPPGVVNVVNGFGaeaGKPLASSDrIAKVAFTGETTTGRLIMQYAShnLIP 259 Mycobacterium t...
YP_001543935 179 LAAGNCVVLKPAEqTPSTILVLMELIGdLIPAGVVNVVNGFGieaGKPLASSNrIAKIAFTGETTTGRLIMQYASenIIP 258 Herpetosiphon a...
Q9RYG9       189 LAAGNAVVLKPAEqTPASIMVLMELIAdLLPEGVVNVVNGFGleaGKPLASSPrIAKIAFTGETNTGRLIMGYAAdnLIP 268 Deinococcus rad...
NP_814048    174 LAAGNTVVIHPSSsTSLSLLELFKIFDqVLPKGVVNLITGRGsdsGNYMLAHPgFDKLAFTGSTEVGYTVAKAAAdrLIP 253 Enterococcus fa...
YP_001558079 169 LAAGDVSVFKPSStTSLSVLELMRLIEnVVPKGVINIVTGKGsksGEYLQHHKgLDKLAFTGSTEVGREVGISAAqnLIP 248 Clostridium phy...
NP_603351    169 LAAGDTVVLKPSStTTLSLLVLMELIQdVIPKGVVNLVTGKGstaGEFLKNHPdLDKLAFTGSTAVGRDIALAAAekLIP 248 Fusobacterium n...
YP_001407270 168 IAAGDTTVFKPSSeTSLSILELMKLIKdVVPKGVVNVITGRGsksGEWLKEHPgIDKLAFTGSTAVGRDVGIAAAkrIIP 247 Campylobacter h...
Feature 1           #                                   #  #                                     
P46368       259 VTLELGGKSPNIFFEDvlaaddAFFDKALEGFAMFALNQGEVCTCPSRALIQesIYDRFMERALKRVAAIrqGHPLDtgT 338 Ralstonia eutro...
Q5HJK3       253 ATLELGGKSANIILDDa-----NLDLAVEGIQLGILFNQGEVCSAGSRLLVHekIYDQLVPRLQEAFSNIkvGNPQDeaT 327 Staphylococcus ...
Q9ZA11       259 VTLELGGKSPNVFFDDiasaddSFFDKAVEGFVMFALNQGEICTCPSRALIHesLYDRFIERALARVAVIkqGSPLDteT 338 Rhodospirillum ...
P63938       260 VTLELGGKSPNIFFADvlaahdDFCDKALEGFTMFALNQGEVCTCPSRSLIQadIYDEFLELAAIRTKAVrqGDPLDteT 339 Mycobacterium t...
YP_001543935 259 VTLELGGKSPNIFFEDvlskqdSFVDKALEGFTMFALNQGEVCTCPSRALIQksIYGEFLERAVERTKRCiqGNPLDpaT 338 Herpetosiphon a...
Q9RYG9       269 VTLELGGKSPNIFFDDvmmeddAFLDKAVEGMVMFALNQGEVCTCPSRALIQesIYDRFMERAVQRVEAItmGHPLDpgT 348 Deinococcus rad...
NP_814048    254 ATLELGGKSANIIFEDa-----NWERALEGVQLGILFNQGQVCCAGSRVFVQsgIYDQFVEALKEKFEQVnvGFPWEkdV 328 Enterococcus fa...
YP_001558079 249 STLELGGKSANIFFSDa-----DMDIALEGIQLGILFNQGQVCSAGSRIFVQedFYDEFIEKAIAAFEKVkvGNPLDptT 323 Clostridium phy...
NP_603351    249 ATLELGGKSANIILDDa-----DIEKALEGAQLGILFNQGQVCCAGSRIFVQegIYDEFISKLVKKFENIkiGNPLDptT 323 Fusobacterium n...
YP_001407270 248 ATLELGGKSANIIYADa-----DIEKALDGVQMGILFNQGQVCCAGSRIFVEegIYDEFIKKAVEKFKNIkvGDPLDknT 322 Campylobacter h...
Feature 1                                                                                        
P46368       339 MIGAQASAEQLEKILSYIDLgrkEGAQCLTGGERnvld-gdlaGGYYVKPTVFAghnkmRIFQEEIFGPVVSVTTFKdEE 417 Ralstonia eutro...
Q5HJK3       328 QMGSQTGKDQLDKIQSYIDAakeSDAQILAGGHRlten-gldkGFFFEPTLIAVpdnhhKLAQEEIFGPVLTVIKVKdDQ 406 Staphylococcus ...
Q9ZA11       339 MIGAQASTEQMDKILSYMDIgreEGATVLAGGARaelg-geldGGYYVQPTVFKgnnsmRIFQEEIFGPVVAVTTFKdED 417 Rhodospirillum ...
P63938       340 MLGSQASNDQLEKVLSYIEIgkqEGAVIIAGGERaelg-gdlsGGYYMQPTIFTgtnnmRIFKEEIFGPVVAVTSFTdYD 418 Mycobacterium t...
YP_001543935 339 MVGAQASNDQFEKILSYLAIgrdEGAKVLVGGAKaelsgdlaeGYYVQPTIFAGnn-rmRIFQEEIFGPVVSVTSFDdFD 417 Herpetosiphon a...
Q9RYG9       349 MIGAQASTEQLDKILSYLDIgraEGAEVLTGGERgqre--gleEGFYVKPTIFKghnkmRIFQEEIFGPVLAAATFKdEA 426 Deinococcus rad...
NP_814048    329 EMGAQINEHQLEEILKYVEIgvkEGATLITGGQRlten-gldkGAFLAPTLLANgtnamCVAQEEIFGPVATVIKFEtEE 407 Enterococcus fa...
YP_001558079 324 QMGAQVSEQQLKKILSYVEIgknEGAKVATGGERfveg-davnGYFMKPTLLVNvtndmRVAREEIFGPVGVVIKFKtID 402 Clostridium phy...
NP_603351    324 IMGSQIDARQVKTILDYVEIakqEGGVILTGGVKyten-gcdkGNFVRPTLITNvnngcRVSQEEIFGPVAVVIKFKtDD 402 Fusobacterium n...
YP_001407270 323 QMGSQINKKQADKVLHYIDIaleEGAKIVVGGKRsa-----agEAFIEPTLIVNvtndmRVAQEEIFGPVGVVIKFKnED 397 Campylobacter h...
Feature 1                                                                                        
P46368       418 EALAIANDTLYGLGAGVWTRdGARAFRMGRgIQAGRVWTNCYHaYPAHAAFGGYKQSGIGRENHRMMLDHYQQTKNLLVS 497 Ralstonia eutro...
Q5HJK3       407 EAIDIANDSEYGLAGGVFSQnITRALNIAKaVRTGRIWINTYNqVPEGAPFGGYKKSGIGRETYKGALSNYQQVKNIYID 486 Staphylococcus ...
Q9ZA11       418 EALHLANDTHYGLGSGVWTRdGNRAFRFGRgIKAGRVWTNCYHlYPAHAAFGGYKQSGIGRENHHMMLDHYQQTKNLLVS 497 Rhodospirillum ...
P63938       419 DAIGIANDTLYGLGAGVWSRdGNTAYRAGRdIQAGRVWVNCYHlYPAHAAFGGYKQSGIGREGHQMMLQHYQHTKNLLVS 498 Mycobacterium t...
YP_001543935 418 DALSIANDTLYGLGAGLWTRdMNTAYRMGRaIQAGRVWTNCYHlYPAHAAFGGYKHSGIGRENHKMMLNHYQQVKNLLVS 497 Herpetosiphon a...
Q9RYG9       427 EALELANDTLYGLGAGLWTRdISRAYRMGRgIQAGRVWTNCYHvYPAHAAFGGYKQSGIGRENHRMMLDHYQQTKNLLVS 506 Deinococcus rad...
NP_814048    408 EVIRLANDSEYGLGGAVFSQdINVALRVARgVRTGRMWVNTYNqLPAGAPFGGYKKSGIGRETHKSMLDAYTQMKNIYIV 487 Enterococcus fa...
YP_001558079 403 EVIDMANDSDYGLAGGVFTKdINKAIKVARgIRTGRIWVNTYNiFPAGASFGGYKDSGIGRETHKVILDHYSQMKNIIIN 482 Clostridium phy...
NP_603351    403 EVIAQANDSEYGLGGAVFTKnINRALKLAReIQTGRVWINTYNqIPEHAPFGGYKKSGIGRETHKVILEHYTQMKNILID 482 Fusobacterium n...
YP_001407270 398 ELIKMVNDSEYGLGGGVFTKdITKALRTARsMETGRVWINCYNqIPAGAPFGGYKNSGIGRETHKMILNHYTQAKNIMID 477 Campylobacter h...
Feature 1         
P46368       498 Y 498 Ralstonia eutropha H16
Q5HJK3       487 T 487 Staphylococcus aureus subsp. aureus USA300_TCH1516
Q9ZA11       498 Y 498 Rhodospirillum rubrum ATCC 11170
P63938       499 Y 499 Mycobacterium tuberculosis C
YP_001543935 498 Y 498 Herpetosiphon aurantiacus ATCC 23779
Q9RYG9       507 Y 507 Deinococcus radiodurans R1
NP_814048    488 T 488 Enterococcus faecalis V583
YP_001558079 483 L 483 Clostridium phytofermentans ISDg
NP_603351    483 L 483 Fusobacterium nucleatum subsp. nucleatum ATCC 25586
YP_001407270 478 L 478 Campylobacter hominis ATCC BAA-381

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