1W25,2W01,1WC0,1CJK,2V0N,3BRE,3EZU,1FX4,1YBU,1Y10,1YK9,1AB8,3ET6


Conserved Protein Domain Family
Nucleotidyl_cyc_III

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cd07556: Nucleotidyl_cyc_III 
Click on image for an interactive view with Cn3D
Class III nucleotidyl cyclases
Class III nucleotidyl cyclases are the largest, most diverse group of nucleotidyl cyclases (NC's) containing prokaryotic and eukaryotic proteins. They can be divided into two major groups; the mononucleotidyl cyclases (MNC's) and the diguanylate cyclases (DGC's). The MNC's, which include the adenylate cyclases (AC's) and the guanylate cyclases (GC's), have a conserved cyclase homology domain (CHD), while the DGC's have a conserved GGDEF domain, named after a conserved motif within this subgroup. Their products, cyclic guanylyl and adenylyl nucleotides, are second messengers that play important roles in eukaryotic signal transduction and prokaryotic sensory pathways.
Statistics
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PSSM-Id: 143637
View PSSM: cd07556
Aligned: 13 rows
Threshold Bit Score: 114.376
Threshold Setting Gi: 56966618
Created: 28-May-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
nucleotidylmetal binding
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:nucleotidyl binding site
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1            ######                                             #                     
1W25_A    319 PVSALLIDIDFFKkindtf----ghdigDEVLREFALRLASNVra----iDLPCRYGGEEFVVIMPd------------- 377 Caulobacter vibrio...
2W01_A     14 PITILTSDLRGFTstsegl----npeevVKVLNIYFGKMADVIth---hgGTIDEFMGDGILVLFGapts---------- 76  Synechocystis sp.
1WC0_A     27 LITILFSDIVGFTrmsnal----qsqgvAELLNEYLGEMTRAVfe---nqGTVDKFVGDAIMALYGapeem--------- 90  Arthrospira platensis
1CJK_A     26 NVSILFADIEGFTslasqc----taqelVMTLNELFARFDKLAae---nhCLRIKILGDCYYCVSGlpea---------- 88  dog
2V0N_A    319 PVSALLIDIDFFKkindtf----ghdigDEVLREFALRLASNVra----iDLPCRYGGEEFVVIMPd------------- 377 Caulobacter vibrio...
3BRE_A    202 QLSLLMIDVDYFKsyndtf----ghvagDEALRQVAGAIREGCsr---ssDLAARYGGEEFAMVLPg------------- 261 Pseudomonas aerugi...
3EZU_A    213 NVGIXLIDLDYFKlvgdny----ghqtgDRILQLVAETITSHLrr----sDVVGRYDGDEFVVYLSp------------- 271 Geobacter sulfurre...
1FX4_A     12 PVTLIFTDIESSTalwaa-----hpdlmPDAVATHHRLIRSLItr---yeCYEVKTVGDSFMIASK-------------- 69  Trypanosoma brucei
1YBU_A     17 LATIMFTDIVGSTqhaaal----gddrwRDLLDNHDTIVCHEIqr---fgGREVNTAGDGFVATFT-------------- 75  Mycobacterium tube...
1Y10_A    215 QVTVAFADLVGFTqlgevv----saeelGHLAGRLAGLARDLTap----pVWFIKTIGDAVMLVCP-------------- 272 Mycobacterium tube...
1YK9_A     10 EASVLFADIVGFTerasst----apadlVRFLDRLYSAFDELVdq---hgLEKIEVSGDSYMVVSGvprp---------- 72  Mycobacterium tube...
1AB8_A     14 CVCVMFASIPDFKefytesdvnkeglecLRLLNEIIADFDDLLskpkfsgVEKIKTIGSTYMAATGlsaipsqehaqepe 93  Norway rat
3ET6_B      9 EATVLFSDIVGFTeiasrs----splevXSLLDELYQRFDAAIeey--pqLYKVETIGDAYMVVCNvtvp---------- 72  Chlamydomonas rein...
Feature 1                                                                                     
1W25_A    378 ---tALADALRIAERIRMHVSgspftva-------------------------------hgremlnVTISIGVSAtageg 423 Caulobacter vibrio...
2W01_A     77 -qqdDALRAVACGVEMQLALRevnqqvt--------------------------------glglqpLEMGIGINTgevvv 123 Synechocystis sp.
1WC0_A     91 spseQVRRAIATARQMLVALEklnqgwqerg--------------------------lvgrnevppVRFRCGIHQgmavv 144 Arthrospira platensis
1CJK_A     89 -radHAHCCVEMGMDMIEAISlvrem------------------------------------tgvnVNMRVGIHSgrvhc 131 dog
2V0N_A    378 ---tALADALRIAERIRMHVSgspftva-------------------------------hgremlnVTISIGVSAtageg 423 Caulobacter vibrio...
3BRE_A    262 ---tSPGGARLLAEKVRRTVEslqishd-------------------------------qprpgshLTVSIGVSTlvpgg 307 Pseudomonas aerugi...
3EZU_A    272 ---vEPASLRTVAENLRRSIEeesa-------------------------------------rxvpVTASIGVAQgilgt 311 Geobacter sulfurre...
1FX4_A     70 ----SPFAAVQLAQELQLCFLrldwetnavdesyrefeeqraegeceytpptasldpevysrlwngLRVRVGIHTglcdi 145 Trypanosoma brucei
1YBU_A     76 ----SPSAAIACADDIVDAVAal------------------------------------------gIEVRIGIHAgevev 109 Mycobacterium tube...
1Y10_A    273 ----DPAPLLDTVLKLVEVVDtdn----------------------------------------nfPRLRAGVASgmavs 308 Mycobacterium tube...
1YK9_A     73 -rpdHTQALADFALDMTNVAAqlkdp------------------------------------rgnpVPLRVGLATgpvva 115 Mycobacterium tube...
1AB8_A     94 rqymHIGTMVEFAYALVGKLDainkh------------------------------------sfndFKLRVGINHgpvia 137 Norway rat
3ET6_B     73 -cddHADVLLEFALRMHEEASrvass------------------------------------lgepVRIRVGMHSgpvva 115 Chlamydomonas rein...
Feature 1                          #               
1W25_A    424 d-----------tpealLKRADEGVYQAkasgrnAVV 449 Caulobacter vibrioides
2W01_A    124 gnigsekrtkygvvgaqVNLTYRIESYTtg---gQIF 157 Synechocystis sp.
1WC0_A    145 glfgsqersdftaigpsVNIAARLQEATap---nSIM 178 Arthrospira platensis
1CJK_A    132 gvlglr-kwqfdvwsndVTLANHMEAGGka---gRIH 164 dog
2V0N_A    424 d-----------tpealLKRADEGVYQAkasgrnAVV 449 Caulobacter vibrioides
3BRE_A    308 gg---------qtfrvlIEMADQALYQAknngrnQVG 335 Pseudomonas aeruginosa
3EZU_A    312 dv--------dggieelVRLADECLXQAkytgknKVV 340 Geobacter sulfurreducens
1FX4_A    146 rydev--tkgydyygrtSNMAARTESVAng---gQVL 177 Trypanosoma brucei
1YBU_A    110 rdas----hgtdvagvaVHIGARVCALAgp---sEVL 139 Mycobacterium tuberculosis H37Rv
1Y10_A    309 ra--------gdwfgspVNVASRVTGVArp---gAVL 334 Mycobacterium tuberculosis
1YK9_A    116 gvvgsr-rfrycvwgdaVNVASRMESTDsv---gQIQ 148 Mycobacterium tuberculosis
1AB8_A    138 gvigaq-kpqydiwgntVNVASRMDSTGvl---dKIQ 170 Norway rat
3ET6_B    116 gvvgrk-mprfxlfgdtVNTASRMESHGea---gQIH 148 Chlamydomonas reinhardtii

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