Conserved Protein Domain Family
Peptidases_S8_15

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cd07498: Peptidases_S8_15 
Peptidase S8 family domain, uncharacterized subfamily 15
This family is a member of the Peptidases S8 or Subtilases serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.
Statistics
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PSSM-Id: 173822
View PSSM: cd07498
Aligned: 17 rows
Threshold Bit Score: 227.996
Threshold Setting Gi: 166363984
Created: 1-Jun-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
active sitecatalytic triad
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1               #                                            #                            
Q59149        227 TIIAIIDDGVDVDHEEFrssg----kivAPRDVtrktnfp----tpgnrdNHGTACAGVACgng--nfgASGVAPGAKLM 296  Nostoc sp. PC...
YP_412575     175 VTIAILDSGVDPNHPDLsp-------qlVPGWNfyenns-----ntsdvyGHGTKVAGSAAamannaqgVAGVAALAKIM 242  Nitrosospira ...
YP_001997480  250 VVAVMDGSGYDLEHPEFsgkfv--spydAAGSDgnspdddp--spensyaNHGTPCAGIICaltnnnkgVASVGVNIKVQ 325  Chloroherpeto...
NP_488910     236 VVVAVVDDSFDLNHPDFqgs-----gkiVAPRDlrendflp--lpsekerSHGTACAGIALaeen-gagIVGVAPGCALM 307  Nostoc sp. PC...
YP_001304750  226 IKVAVIDQGVAGHEDLGdr--------lLPGFTpglangn---gapvsnnPHGECCAGIIGashn-nlgIAGIAPLVKIV 293  Parabacteroid...
NP_635087     225 IKVAILDDGIDTGHQEFsgkiv-aqhdfASGGDdgspn--------tnddNHGTACAGVAVakg---vrASGAAPGCSLI 292  Methanosarcin...
YP_001617219  198 TSIVVIDTGCDLDHPDLaa-------kmDPGLDvidddddptyqpgeqsvNHGTACAGLIAadtnngvgIAGGCPACRLR 270  Sorangium cel...
NP_841613     173 ITIAILDTGVDGTHPDLaa-------nmLPGWNaydnnt-----dtsdiyGHGTKVAGTAAavanngagSSGLAWNARIL 240  Nitrosomonas ...
AAK40114      222 TIIAVIDDGFDMGHPEFsrkgkivhpcnLSGVNtdddpt------pgkydTHGTPCAGVACadg--rygASGVAPEANLM 293  Yersinia ente...
CAO81168      199 IIIAIIDSGVDTAHPDLrlv-----agyDFGDNdsnpmd------nsaepGHGTACSGIAAakannslgITGIAGGCSVM 267  Candidatus Cl...
Feature 1                                                #                                        
Q59149        297 PIRfvsal----gsqdEADSFVWAa----qNGADVISCSWGppdgtwwddkdplhkqkvplpdstrlamDYAINKGRngK 368  Nostoc sp. PC...
YP_412575     243 PVRvsgstg-yatwsaISQGLIYAa----dRGVRVANASFLgltd--------------------sastRSAAQYMKd-K 296  Nitrosospira ...
YP_001997480  326 PINigysnynggfqtnDATISRAAskiiatPGVVAVSNSWGggtkne----------------slensyHSIRTQSRdgK 389  Chloroherpeto...
NP_488910     308 PIRttgfl----ddesIEQIFNWAm----eKGASVISCSWGasavyfpl------------slrqraaiTRAATRGRngK 367  Nostoc sp. PC...
YP_001304750  294 PVNifysq----sssnIAAAINYAwd---dAEADVISNSWGgsvada-----------------itsaiNNARTNGRggL 349  Parabacteroid...
NP_635087     293 AVRypdfl----gleeEAQMFRWAk----dQGSDVISCSWGpkdgtgavdp---------lpdnvraavHYCVTQGRngL 355  Methanosarcin...
YP_001617219  271 CVRliddep--rpisaSVDAFEFAl----qVNAAVVSNSWGyadpmpvp-------------rvveaaiNRLFDAGRngK 331  Sorangium cel...
NP_841613     241 PVRismpdg-raylsdMAKGIRWAa----dNGARIANISYGgaes---------------------ltvQSAANYMRs-K 293  Nitrosomonas ...
AAK40114      294 PIRqaggl----gsldEALAFVWAt----dNGADVISCSWGpkgslsansddpqhdvvaalpaltrmaiDYAIDKGRkgK 365  Yersinia ente...
CAO81168      268 PLKvadsdg-dmyftaIENALTYAa----dNNAHIASMSLGatdvae----------------gdspstDAALNYAYn-A 325  Candidatus Cl...
Feature 1                                                                                         
Q59149        369 GCVILFAAGNgnesvdnd-------------------gyasyekVIAVAACndfgt-----------------rsaysDF 412  Nostoc sp. PC...
YP_412575     297 GGLVIVSGGNtgvlqn----------------------yavttsMVAVAATdandf-----------------raswsSY 337  Nitrosospira ...
YP_001997480  390 GAVILFSSGNsgtngvg--------------------yparadnIIAVGATenndk-----------------rtyfsQY 432  Chloroherpeto...
NP_488910     368 GCVVLFAAGNanrpvsgaiyeqdwpgnvlqgvtdwlngfgvhpdVMTIAAStsmsk-----------------kaaysNW 430  Nostoc sp. PC...
YP_001304750  350 GCVVVFAAGNsgssvsf---------------------patvngVIAVGAVdknga-----------------lcsysAR 391  Parabacteroid...
NP_635087     356 GIPIFWAAGNgnesvsnd-------------------gyasnpeVMAVAASsnner-----------------rspysDF 399  Methanosarcin...
YP_001617219  332 GALVLFAAGNddreildd-------------------elqavrgVLTVGAVnhled-----------------atsftNR 375  Sorangium cel...
NP_841613     294 GGVVVMSAGNsgglnn----------------------fpasnaIIVASATdskda-----------------raswsSY 334  Nitrosomonas ...
AAK40114      366 GCVVLLAAGNgnesvekd-------------------gyasyepVIAVAACndrsi-----------------rsvysNY 409  Yersinia ente...
CAO81168      326 CVVIFAATGNennstis--------------------ypanqtsVISVGAAsptgqrkstsssdgeywwgsnygvatqNN 385  Candidatus Cl...
Feature 1                                                                        #                
Q59149        413 GQAVWCAFPsnngnpsqtpgiwtadrsg----------vvgynsgstnlgdqagnytNSFGGTSSACPGAAGVAALILSR 482  Nostoc sp. PC...
YP_412575     338 GNYISLAAPgagiwtt-----------------------------------tmgggyGAASGTSFSSPVTAGVVALMMAA 382  Nitrosospira ...
YP_001997480  433 GTDLDVVAPgsdiytldrqdg-------------------------llkqgynwgdyVSFSGTSAACPIAAAVVGLMASQ 487  Chloroherpeto...
NP_488910     431 GLNISLCAPsnnaspgmsfpekgflytqpsiktnlsglgmlttdivgaagydpgnftSNFGGTSSATPVVAGVAALVLSV 510  Nostoc sp. PC...
YP_001304750  392 GSEINLVAPsgaldytgdirtld---------------------lmgsaglypgnylSTFGGTSASCPQVSGVAALLLSI 450  Parabacteroid...
NP_635087     400 GPEVFICAPssgsgslgewriftvdrrgsn-------gynpdpdtgishpandhdytDDFGGTSSATPLAAGITGLLLSI 472  Methanosarcin...
YP_001617219  376 GRSIDLVAPtgtlstdiag----------------------------segddasdytDRFGGTSSACPVAAGVAGLLVSA 427  Sorangium cel...
NP_841613     335 GPYVDVAAPgvsiytt-----------------------------------irgggyGYVSGTSFSSPIVAAAAALLFSI 379  Nitrosomonas ...
AAK40114      410 GKSLWCSFPsddsedlilghpaplttgiwttd--lrreygdnpgastavgdifgnyiNNFGGTSSACPGAAGVAALIISV 487  Yersinia ente...
CAO81168      386 KNAVDIMAPtilpatdltgt--------------------------gngyntsgdyyLWFNGTSCATPYAAGVAALLLSK 439  Candidatus Cl...
Feature 1                         
Q59149        483 NPNLrwdeVRDIIKRS 498  Nostoc sp. PCC 7120
YP_412575     383 KPTLsntqIESLLFST 398  Nitrosospira multiformis ATCC 25196
YP_001997480  488 NPNLtaseLENYLQQT 503  Chloroherpeton thalassium ATCC 35110
NP_488910     511 NPDLtaqqVKRILETT 526  Nostoc sp. PCC 7120
YP_001304750  451 NPKLteaeVRNILGHS 466  Parabacteroides distasonis ATCC 8503
NP_635087     473 NPNLrvedVKQILRDT 488  Methanosarcina mazei Go1
YP_001617219  428 APERtageLYDVMIRT 443  Sorangium cellulosum 'So ce 56'
NP_841613     380 NPDLaptdIDQMLTAT 395  Nitrosomonas europaea ATCC 19718
AAK40114      488 NPTLnyqeVKDIIRDS 503  Yersinia enterocolitica
CAO81168      440 DPSLtpaqIFSILTSS 455  Candidatus Cloacamonas acidaminovorans

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