Conserved Protein Domain Family
Peptidases_S8_13

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cd07496: Peptidases_S8_13 
Peptidase S8 family domain, uncharacterized subfamily 13
This family is a member of the Peptidases S8 or Subtilases serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.
Statistics
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PSSM-Id: 173820
View PSSM: cd07496
Aligned: 26 rows
Threshold Bit Score: 296.512
Threshold Setting Gi: 15806936
Created: 28-May-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
active sitecatalytic triad
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1               #                                                                        
P23314       170 GTVVAVIDTGITSHADLNANIL---AGYDFISDATTARDGNGRDsnaadegdwyaan----------------------- 223  Xanthomonas ca...
ZP_01625526  419 GVVVAVIDTGIISDHPDIRGQLi--DGYDFISDATSAGDGDGIDpdptdigeg--------------------------- 469  marine gamma p...
YP_762085    420 GIVVAVVDTGLQMSHPDIAASPnimQGYDMVSDPRMGNDGDGRDidandpgdmc-------------------------- 473  Hyphomonas nep...
YP_002512315 157 AVVVAIVDTGILFAHEDLEGKVl-eAGYDFISADPDGEYFTANDgdgrdpdpsdpgdwvt-----------------eee 218  Thioalkalivibr...
YP_001019458 202 SVVVAVLDTGVRFDHPDLAGKLl--AGYDFVSTLPESNDGNGRDsnasdpgdwitqqednsvgg--------dfyhctsp 271  Methylibium pe...
ZP_01915960  165 DVVVAVLDTGVVFETPDLMGRLl--SGYDFVSDVPTANDGNGRDanaadpgnwissada-------------------qt 223  Limnobacter sp...
YP_001790805 214 DIVVAVLDTGVRPEHPDLVGKLl--PGYDFISDANIANDGNGRDgdptdpgdwvatsdi-------------------gs 272  Leptothrix cho...
NP_520775    185 TVTVTVIDTGLLAGHADLSGATi-qPGYDFVSSTAMTGTPDPVTnlsipsgfvendatagrdsdptdpgdwittsdatny 263  Ralstonia sola...
ZP_01914805  163 PTVVAVLDTGVLPSHPMLQGHLl--SGYDFVADPLIGADGQSSGgsdrdsdptdpgdgvgp---------------adll 225  Limnobacter sp...
NP_295660    103 PVTVAVLDTGYVASPELAGRVV---NGYDFVSDAARSGDGGRRDrdaga------------------------------- 148  Deinococcus ra...
Feature 1                     #   #                                                              
P23314       224 ecgagipaasssWHGTHVAGTVAavtn-nttgVAGTAYGAKVVPVRVLGkcgg-slsDIADAIVWASGgtvsg------- 294  Xanthomonas ca...
ZP_01625526  470 ----snplrsgdFHGLHVTGTIGatgn-nnrgIAGVAYSSRIMPLRALGadgsgstyDILQAVRYAAGfsnda------- 537  marine gamma p...
YP_762085    474 --dpnkpnaadsFHGTHVAGTIGaaatnngsgVAGGAWDVRIVPVRALGkcgg-rlsDINDAIRWAAGlipaevnegpqv 550  Hyphomonas nep...
YP_002512315 219 aeerecrvshssWHGTHMAGIVAasts-ngkgIAGVSWGAMILPIRALGkcdg-yssDVIDAMRWAAGlpvag------- 289  Thioalkalivibr...
YP_001019458 272 dslgnyngapssWHGTQVAGIVGaltn-ngvgMAGTGWNTRVLPVRVLGkcgg-yvsDVVIGMRWAAGltvpn------- 342  Methylibium pe...
ZP_01915960  224 safsgcsvknssWHGTFVAGQIAanth-sdsdVAGADWNVKVLPVRVLGkcgg-llsDVLDAMLWSAGldvpg------- 294  Limnobacter sp...
YP_001790805 273 lvastcveedssWHGTQMAGLVGaath-ngsgMAGVGRHVMVLPVRVLGkcgg-fvsDIVAGMRWAAGvsvpg------- 343  Leptothrix cho...
NP_520775    264 psfcgtsvtdssWHGTFVTGLIAaqhn--aigVAGVAPGVSVQMTRAIGkcgg-assDILDALTWAAGgtvpg------- 333  Ralstonia sola...
ZP_01914805  226 adpvcgglsqssWHGTFVSALLAgnpa-psegVFSVNWNAVVLPVRVLGkcgg-fssDLADGIRWAAGlsvpg------- 296  Limnobacter sp...
NP_295660    149 -------vgqfaYHGEIVANLIAaahd--grgMAGINPRARIVHVRVADvngqiapqDLVDGLRWAAGlsvpg------- 212  Deinococcus ra...
Feature 1                       ###                             # ##                             
P23314       295 --ipanaNPAEVINMSLGgggsc----sttmQNAINGAVsrgTTVVVAAGNDasnv----sgslPANCANVIAVAATtsa 364  Xanthomonas ca...
ZP_01625526  538 --ntlpsNPAAVINLSIGgagf-----sqtaQNLYTAVAksgILIAAASGNDgssn-----vdyPGGYADIFAVGATdav 605  marine gamma p...
YP_762085    551 wtevwneNPADIINLSIGllgac----paslQDAIDAVTeegVIVVSAAGNArmst----slyaPAGCRNVVTVAASdar 622  Hyphomonas nep...
YP_002512315 290 --vpnnhDAAKIINMSLGanqsc----tgawLDAVNAVHekgSLIVAAAGNGgvsmsssrnhvvPGVCPGVLTVAATnka 363  Thioalkalivibr...
YP_001019458 343 --iaanpNPARILNLSLGtegg-----cgeyQDAVDDVVaagALVVAAAGNTngha-----vgaPGNCSGVMAVGGLrhs 410  Methylibium pe...
ZP_01915960  295 --iprnpNPADVINLSLGspttc----tsfeQTVVDRVNaagTLVVAAAGNSggs------vdsPANCNNVLSVGALdrd 362  Limnobacter sp...
YP_001790805 344 --vpanpHPARVLNMSLGgegac----satyQSAVDDVIaarAVVVSSGGNEgla------vdmPANCVGVIAVGGVrhs 411  Leptothrix cho...
NP_520775    334 --vttnaTPAKVINMSLGgstac----ttaqQSAITAARslgATIVVATGNEfqna----aidaPASCSGTIAVTAHtle 403  Ralstonia sola...
ZP_01914805  297 --vpnnpFPAKVINLSLGaegac---vpsieGAAISAARqagSLVVVAAGNDgst------vdsPANCPGAFGVAAIdqe 365  Limnobacter sp...
NP_295660    213 --vpnnpNPARVLNLSLFadfipltgcdariQKAVDDVTakgALVVVGAGNDgrda----sgysPAGCRNVLTVTSVder 286  Deinococcus ra...
Feature 1                                                                        #               
P23314       365 gakaSYSNFGTGIDVSAPGssilstlnsg--------------------tttpgsasyASYNGTSMASPHVAGVVALVqs 424  Xanthomonas ca...
ZP_01625526  606 ngisDYSNRGPALDLVAPGgrlgadangdgqpd-----------giistyysdglpeyVFLQGTSMATPHVAGVFALMks 674  marine gamma p...
YP_762085    623 gqiaPYSNFGPEVMVLAPGgdltrddngdgkpdgvlstkaatncydpvtgegvencfyAYEQGTSMAAPHVSAALALLks 702  Hyphomonas nep...
YP_002512315 364 gdraSFSNYGPQIDLGAPGiwvlstsdqg-------------------ttsplddshyENKSGTSVSAPQVAGVAALLls 424  Thioalkalivibr...
YP_001019458 411 gtkvGFSDLGSAVSISAPAgncvndfgpclypllttt----nsgsqgpassaytdgtnDITVGTSFSAPLVSGVAALMla 486  Methylibium pe...
ZP_01915960  363 gsraSYSAIGTAVSLMAPGgfsnglvglgn-----------------sgtttpasaslVSKTGTSFAAPLVAATAGLMra 425  Limnobacter sp...
YP_001790805 412 gtknGFSSLGPEIAISAPGgncvntdgqaclypilst---sntgttapgtatftdgqiRPAFGTSYASPLVAGTAALMla 488  Leptothrix cho...
NP_520775    404 gdiaNYANVGTGTTLSAPGggngstatglgalvp---------stsnagtttastdtyVGEEGTSMSTPQVAGVAALMls 474  Ralstonia sola...
ZP_01914805  366 glkaNYSNFGPSIQLSAPGgdaafpiwsasn----------------tgfagpltntyNTKIGTSFSSPMVAGAASLYws 429  Limnobacter sp...
NP_295660    287 glrpGYANWGRAVSLGAPGgdpahgvva---------------------ssvsgsggeRDPNGTSFAAPHAAGVASLLls 345  Deinococcus ra...
Feature 1                          
P23314       425 vaptaltpaaVETLLKNT 442  Xanthomonas campestris pv. campestris
ZP_01625526  675 vnpn-ldastVEDLLQLG 691  marine gamma proteobacterium HTCC2080
YP_762085    703 rdpa-asrddIISTLRAA 719  Hyphomonas neptunium ATCC 15444
YP_002512315 425 ydds-ldrqdLIYLLTSN 441  Thioalkalivibrio sp. HL-EbGR7
YP_001019458 487 vqpt-ltpdeIRGLIQGG 503  Methylibium petroleiphilum PM1
ZP_01915960  426 inpa-lttaqLRSQILGS 442  Limnobacter sp. MED105
YP_001790805 489 vqpt-lspaqIRQMLRAS 505  Leptothrix cholodnii SP-6
NP_520775    475 vnaa-ltpdqIKTILQTS 491  Ralstonia solanacearum GMI1000
ZP_01914805  430 lnps-asvatVENLLKTT 446  Limnobacter sp. MED105
NP_295660    346 vrpe-lsratLTTLLTRQ 362  Deinococcus radiodurans R1

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