Conserved Protein Domain Family
Peptidases_S8_9

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cd07493: Peptidases_S8_9 
Peptidase S8 family domain, uncharacterized subfamily 9
This family is a member of the Peptidases S8 or Subtilases serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.
Statistics
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PSSM-Id: 173818
View PSSM: cd07493
Aligned: 19 rows
Threshold Bit Score: 341.207
Threshold Setting Gi: 66827329
Created: 11-Dec-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
active sitecatalytic triad
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1               #                                         #                              
YP_001194735 170 GKIIAVLDAGFPGVNtaqpfenlrnnnRILGGYDFTTrndnf--ytgdDHGTLVLSTMGgykenalvGTAPNASYYLFIt 247 Flavobacterium ...
YP_678214    162 GILIAVTDSGFPGVDtltafkhlwennQITYFYDVADneadv--fndgSHGTYILSVLAadtl-vykGVVPEASYVLLRt 238 Cytophaga hutch...
ZP_02033125  197 GMRVAVIDAGFMNADrvsa----fdslRLLGTHNVVFpgksv--fvgdDHGTKVLSCLAadipgvmvGTAPKASYLLLKs 270 Parabacteroides...
NP_812800    171 GMTIAVIDAGFHNADriea----mkniRILGTRDFVNpeadi--yaesNHGMSVLSCMAmnqpnvmvGTAPEASYWLLRs 244 Bacteroides the...
ZP_01688208  191 GIAIAVMDAGFQNVNslnffkhlfsnqQIGGTYDLVDnkvdv--ystgSHGTKVLSTMAaylkgtmvGTAPEATYWLYRt 268 Microscilla mar...
ZP_01118825  171 GMLIAVIDGGFPNVDkllalqrlrdnnQILGGYDFVNksvdf--ytgsNHGTNVLSDIAgfvegvfvGTAPDASFYLFIs 248 Polaribacter ir...
YP_862255    166 GVTIAVMDGGFANVNtigafdrlklngKLLGGFDFTNrsgnysnpelsNHGTLVLSNMAgfiennfvGTAPDAAYYLFIt 245 Gramella forset...
YP_001296637 174 GKVVAILDAGFPGVNtadpfaslrtrgLILGGYNFVNnstnf--ytgnNHGTNVLSTMGgntt-nlvGTAPDASYYLFIt 250 Flavobacterium ...
ZP_01718106  179 GITVAVFDAGFPGTDeasalshlfannQIIKANNFVRpwsdn-iftanQHGTNVLSLIAaneegilkSGAPDADYYLAIt 257 Algoriphagus sp...
ZP_03677246  268 GIDIAVIDAGFMDLLnnpt----lntmHIQGAKSFVYedsnp--ynsdEHGLWVTACMAtdkpgyyiGTAPEANYWLLRs 341 Bacteroides cel...
Feature 1                                       ###                                        # ##  
YP_001194735 248 eidavenPVEESLWVEAAEradalgvDIITTSLGYFGdrteprynhtysdmnGITTFISRGAEIAFskgILVLASAGNEg 327 Flavobacterium ...
YP_678214    239 evaatetQTEEFNWLRAAEiadscgvDIISVSLGYTTyddntds-ytyadmdGQTSVIAAAADMAYgkgMIVVCSAGNDg 317 Cytophaga hutch...
ZP_02033125  271 edsdseyPVEEDYWTAAVEyadsagvDVISSSLGYFAfdtdels-ydqdaldGRTAMISRAANLAAdkgILVFCSAGNEg 349 Parabacteroides...
NP_812800    245 edeasehLVEQDYWAAAIEfadsvgvDVVNTSLGYYTfddptkn-yryrdlnGHYALMSREASKAAdkgMVLVCSAGNSg 323 Bacteroides the...
ZP_01688208  269 edvsseyRIEEVNWLIAAEkadsagvDIINSSLGYNTfddasmn-ytyqnmdGNTTIITQAADFAAavgILVINSAGNEg 347 Microscilla mar...
ZP_01118825  249 edvnneaPLEESLWVEAAEradslgvDIINTSLGYTTfdndnys-hsyadmdGSTTFISRGAEIGAsrgMLLVNAAGNSg 327 Polaribacter ir...
YP_862255    246 eigptetPVEETYWVEAAEradslgvDLINTSLGYTLfdnpdys-yapedmdGKTAFISRGANIATekgLLIVTSAGNRg 324 Gramella forset...
YP_001296637 251 edvasetPLELTNWVEAAEeadrlgvDVINSSLGYFRfdnpays-ytyakmnGQTSVASRAVDIAFskgMICVISAGNEg 329 Flavobacterium ...
ZP_01718106  258 eedateyKIEEYNWVRAAEvadslgvDIINSSVGYWDfddptmn-ysledldGKTTVIAQGANIAAqrgILIINSVGNYg 336 Algoriphagus sp...
ZP_03677246  342 edlsgeyPVEEDYWVAAIEyadsvgaDVVNTSLYYTGnrwpfps-heyeemdGKTALPTRAANVAAnkgIFIACCAGNDg 420 Bacteroides cel...
Feature 1                                                                             #          
YP_001194735 328 nttekhvgSPADAVSVLAIGAVtaskvksSFSSIGPSYDNRIKPDVMAqgsaatv-anangsiGTADGTSFSCPIIAGMA 406 Flavobacterium ...
YP_678214    318 nnawkyigTPADAKKVLAVGSVdftntksGFSSIGPTADGRLKPDLCAtgaginc-ikpdgtiLMTGGTSLSTPMIAGMI 396 Cytophaga hutch...
ZP_02033125  350 sgdwekitFPSDAGGIFTVGAIdedkkksGFSSVGFTADGRVKPDAVAlgtsscv-igpdgnvRYANGTSFATPILAGMG 428 Parabacteroides...
NP_812800    324 sgswkkitPPGDAENVLTVGAIdkkkllaPFSSVGNTADGRVKPDVVAvglkadi-vgtdgnlRLANGTSFSSPIMCGMV 402 Bacteroides the...
ZP_01688208  348 ndpwkyigAPADGDSVLTVGAVnpngtyaSFSSKGYTSDGRLKPNITAmgsnvtl--vgpfgsTVGNGTSFSAPTLTGLA 425 Microscilla mar...
ZP_01118825  328 stswkymgAPADAAGVFTVGAVnaveniaSFSSFGPTADNRTKPDVLAhgenifvidhltglpKPSNGTSFSSPVMSGVV 407 Polaribacter ir...
YP_862255    325 eenyfniiSAPADANVLSVGGVdrnrnyvTFSSRGPSADGRVKPDVAAqgleiva-idqfnnlVQASGTSFASPILAGSV 403 Gramella forset...
YP_001296637 330 staephvgTPADAAFAITVGSVtsaevksEFSSIGPTSDGRMKPDFMAmgtaavi-sntagtiTTANGTSFSSPILAGAI 408 Flavobacterium ...
ZP_01718106  337 pke-stliSPADSEMVIAVGAVdknlevsNFSSRGPTGDGRLKPDLTTygngval-irsngnlGYSNGTSFSAPQITALA 414 Algoriphagus sp...
ZP_03677246  421 sw----vgTPADSPNVLAVGSVtttggigDFTAYGMTVDGRMKPDVVAlgtsact-idiegriDFRSGTSYASPILCGLA 495 Bacteroides cel...
Feature 1                                    
YP_001194735 407 ASLwqafpt----ktnkeIRQMILASAD 430 Flavobacterium johnsoniae UW101
YP_678214    397 AGIkqtyps----lsndeVKNILLQSCD 420 Cytophaga hutchinsonii ATCC 33406
ZP_02033125  429 VCLwqsl-------pwlnNREMIELLHR 449 Parabacteroides merdae ATCC 43184
NP_812800    403 ACLwqac-------prltAKEVIELVRS 423 Bacteroides thetaiotaomicron VPI-5482
ZP_01688208  426 AGFwqan-------ptltNMQIIDYLQR 446 Microscilla marina ATCC 23134
ZP_01118825  408 ACFwqafpnltntevrqrIREAADRYNS 435 Polaribacter irgensii 23-P
YP_862255    404 ASFwqad-------pslsNLEVMQLVKA 424 Gramella forsetii KT0803
YP_001296637 409 TSFwsaf-------pnktNAQIVQLLKL 429 Flavobacterium psychrophilum JIP02/86
ZP_01718106  415 AGLwqgk-------pewtRAQLVENLFR 435 Algoriphagus sp. PR1
ZP_03677246  496 ACLwqaypw----ltnqeLLEILKKSAN 519 Bacteroides cellulosilyticus DSM 14838

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