Conserved Protein Domain Family
Peptidases_S8_8

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cd07492: Peptidases_S8_8 
Peptidase S8 family domain, uncharacterized subfamily 8
This family is a member of the Peptidases S8 or Subtilases serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.
Statistics
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PSSM-Id: 173817
View PSSM: cd07492
Aligned: 11 rows
Threshold Bit Score: 216.05
Threshold Setting Gi: 114763651
Created: 11-Dec-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
active sitecatalytic triad
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1               #                                          #                             
YP_001615829  26 GVRVALIDSGVDASHPalraaalrhvalvqrgagggaygvapcapgdlsGHGTACAGIVHrma--paaEITSVRalgddg 103 Sorangium cellu...
YP_001826310  20 GVRVCVVDSGVERDHPligplagswvvvkdae--sgeitveptttgdtcGHGTACAGIVRrta--pecEIHSVRvlgerf 95  Streptomyces gr...
ZP_02613952    4 QINVAIIDDGVNEKLYntgvlkynieitpn-----lmirerkkydkyksSHGTTCAAIIKkyl--pysVLSSIKilndkc 76  Clostridium bot...
YP_001782800   4 KSPIIIIDDGVNSDLCnlgelksdievtsd-----leikenldcyneftYHGSTCAAIIKkyl--pnaELGSIKilsnfk 76  Clostridium bot...
CAJ70151      10 KVKVAVLDTGIDKEHDylkdnlvggiafecm----hdyifisdkfddedGHGTACASIIKkey--edvELFVIKilrkdg 83  Clostridium dif...
ZP_03130939   21 GVRIAVLDSGIETSHStfgggalcddlaived--ghrlkvvagegrdlfGHGTAVAGIIRema--peaEIGSIRvlgesl 96  Chthoniobacter ...
NP_637033    190 GVTVAVVDTGVDTSHPdlksrirevhdl----------vddtpvttssdSHGTEVAGIIAagsnnhqgIVGMAPramlsi 259 Xanthomonas cam...
ZP_01443045  148 GVRVGVIDSAIDSDHPdlanrladlrd-----------fvgnaqgsaaePHGTAIAGIIAada---dnEIGMIGvapqaq 213 Roseovarius sp....
YP_970929    195 GTHVAVIDTGAQTGHPdlqgrilethnl----------vdddagafqkdRHGTEVLGIMAatgnnlqgIVGMAPaarfsl 264 Acidovorax aven...
ZP_01574854    5 PINIAVIDDGVNEKLYqtgklafnleithd-----lsvcnrtgydsffmSHGTTCAAIIKkys--peaVLGSIKildsds 77  Clostridium cel...
ZP_03124908    3 RIKVALIDSGIDINHKylknnilygksyiyk----dnkivvsneiedinGHGTSCASIIKsey--eyvDFIIIKifdrdg 76  Clostridium dif...
Feature 1                                               ###                                      
YP_001615829 104 ---------------rcsrdgLVAALRfcvrerfSVVNLSLGidipknaplrpgdyrslvelYEVADAAYta---eVVLV 165 Sorangium cellu...
YP_001826310  96 ---------------sgtgdvLMAGLRwaveqgfDVVNLSLSttrtr----------faqelHSLADSAYfa---rTVIV 147 Streptomyces gr...
ZP_02613952   77 ---------------egsveqLSLALKlcadkeiNLINLSLGstyfd----------dfqilKESLEYCYkk---gVIIV 128 Clostridium bot...
YP_001782800  77 ----------------gtryqLVKAIKwcvenniKLINLSLGtvnfq----------dfkllYSCMEYAYk----kGLII 126 Clostridium bot...
CAJ70151      84 ---------------itnikvLEEALRylldtniRLINLSLSvigv-------------esvKGLFEVCYelfrkgKIIV 135 Clostridium dif...
ZP_03130939   97 s--------------artaiiLEGARQaie-rgyHILNCSLGcgvle----------hvlkyKAWVDEAYl----rGVHV 147 Chthoniobacter ...
NP_637033    260 ykacwya-pstgstarcnsftLAKALAainnssaRVVNLSLGgpad-------------pllRKMLTHLVdh---gRIVV 322 Xanthomonas cam...
ZP_01443045  214 liglracwqpqgmggrcnsfsLARALNfailndvHVLNMSLGgppd-------------pllQELVEAAEa----aGMIV 276 Roseovarius sp....
YP_970929    265 ykacwypaqppgsgarcnsftLAKALVavmssdaRIVNMSLGgpsd-------------pllGQLLSQLVgq---gRIIV 328 Acidovorax aven...
ZP_01574854   78 r--------------tgmkaqLIWALKwcvenriRIVNLSLGtidyr----------dfaeiKEVVDYACe----rNVIV 129 Clostridium cel...
ZP_03124908   77 ---------------ltnikvLEESLNylisidvKIINLSLAihgdi----------nsckdLYKICEKLkn--qnKIIV 129 Clostridium dif...
Feature 1         # ##                                                                      #    
YP_001615829 166 AAGPNAaafrty--pgrfksLIGVGRGafqdpealrs-eltldheilaPGDDVLApapg-------ggeRRWTGTSFAAP 235 Sorangium cellu...
YP_001826310 148 ASAHNTpvesfp---wrfasVISVGSHqeddpelhly-npeppveffgPGQNVTVpwlg-------grtIRTTGNSFATP 216 Streptomyces gr...
ZP_02613952  129 AAISNEntytyp---asltnIIGVKCDkkgrikegk----yiyienslDGVNIISsgshniknfkgingITNNCNSFVVP 201 Clostridium bot...
YP_001782800 127 IAAYNNkriytc--pasfdnVIGVKCDttgtlkrse----yiyntyslDGIEVIAnakhniidnsgmvyTTSICNSYATP 200 Clostridium bot...
CAJ70151     136 CSLANDfdlsyp---amfnnVIGVRGFtldgddsfwy-nkkydvqcvmDSNSYIScdin------nsyrLPPKCNSYLSA 205 Clostridium dif...
ZP_03130939  148 VAACNNadygrpewpafftsVLTVNMArtddnlgify-kpghlvefaaRGVDVDVpwsg-------ggtKKVTGSSFAAP 219 Chthoniobacter ...
NP_637033    323 AAMPPNgrldgf--pndvpgVLVVRSSsataal---------pgvlsaPGKDILTtqpn-------gryDFTSGSSMATA 384 Xanthomonas cam...
ZP_01443045  277 VAAWGEspeptf--paslpgVIAAGHGterq--------------ipaPAVDVISaaph-------ndyRYVSGSSVAAA 333 Roseovarius sp....
YP_970929    329 AAVPAGgqrggf--pagvpgVLAVDSAgaprtps-------pggvllaPGTDILTlqpq-------gryDFASGSSMAAA 392 Acidovorax aven...
ZP_01574854  130 VAACNNrniltc--paslenVIGVKCDlaevlnege----ytfnyasmDGIDITAfakhslkkhdgtntVTGACNSYAAP 203 Clostridium cel...
ZP_03124908  130 SSLANYnyieesy-psifdnVIGVKGNllkkrssfwynseykyqcvvdDSDRIVAdlgn-------sfkLVEKSNSFSAA 201 Clostridium dif...
Feature 1                                      
YP_001615829 236 HVTAHVARIraAWPELSIEAVKAALHGLAR 265 Sorangium cellulosum 'So ce 56'
YP_001826310 217 YVAGLCARVlsAHPRMTAFQLKNALYLSAA 246 Streptomyces griseus subsp. griseus NBRC 13350
ZP_02613952  202 FIISEVYNMmkENLHYDLNSVKKYLKQKSS 231 Clostridium botulinum NCTC 2916
YP_001782800 201 VVTALVYELieKYPDITINEIKTYLRNRSV 230 Clostridium botulinum B1 str. Okra
CAJ70151     206 KLTGKIAKIlsEKPGITISDLNDKLESLAT 235 Clostridium difficile 630
ZP_03130939  220 RVTGMLACLlsEIPDLDPLQTKVLFQRIAT 249 Chthoniobacter flavus Ellin428
NP_637033    385 HVSGMAALLlsLSPSMDANALRALMQRTSK 414 Xanthomonas campestris pv. campestris str. ATCC 33913
ZP_01443045  334 HVSGVVALLraRHHDLAAPDIAHALHGAVV 363 Roseovarius sp. HTCC2601
YP_970929    393 HVSGMVALLqsVEPRLDRDTVERLLLRSEN 422 Acidovorax avenae subsp. citrulli AAC00-1
ZP_01574854  204 FVTSQVYNLirDNPNIDFTEIIGKLQQEAS 233 Clostridium cellulolyticum H10
ZP_03124908  202 KMSGKIAKIiaNKVDISFDGLSRILEELSE 231 Clostridium difficile QCD-23m63

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