Conserved Protein Domain Family
Peptidases_S8_7

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cd07491: Peptidases_S8_7 
Peptidase S8 family domain, uncharacterized subfamily 7
This family is a member of the Peptidases S8 or Subtilases serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.
Statistics
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PSSM-Id: 173816
View PSSM: cd07491
Aligned: 16 rows
Threshold Bit Score: 235.307
Threshold Setting Gi: 145252834
Created: 22-Oct-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
active sitecatalytic triad
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                   #                                             #                       
XP_001398722   77 DLPRVRVALIDDGLDY--SDFDvyph---tevRGFScyppi--gqtehPWHTSTNGHGTAMANMILrinPWIRLLVIRih 149  Aspergillus n...
XP_001903856  217 VGASIKIALIDDGVDY--KDLPkrtf---iggHSFStrdke--rnlihPHYVSIMGHGTAMARHIYymcPSAEIYVLRle 289  Podospora ans...
XP_659798    1033 QPPRIRVALIDDGIDL--DDFNtynnttqytgVSCCdg---------dAWWKSTEGHGTVMANMISrinPWVRLDVIKie 1101 Aspergillus n...
XP_380297     791 LRKDVVVALIDDGVDT--LDPAfsnq--fvegKTFDyqgd----dgvgQYYVSANGHGTDMARMILkvcPMAKIYSIKlk 862  Gibberella ze...
XP_963595     291 IETPIKVALIDDGVDI--MKLDltpaq-clggRTFCprsgphdmcknhPHYISSAGHGTIMAEAILevcPRASLLVLKle 367  Neurospora cr...
EAQ93755      649 LENDVVLALIDDGVDM--FGTAhtgq--ilegKSFDfheg-----kakPSFLSAMGHGTVLASMILrvcPMVKVYPIRlk 719  Chaetomium gl...
XP_001209101  427 PDRRIKVAIIDNGADK--IRSPigs----mieKGISyvssdllgeaprPWWMVADAHGTQMASLIGqinPYCRLYIARvg 500  Aspergillus t...
EAQ88708      839 TDFRVKVALIDDGVDA--NQDIfadm---fgpEGWPvlepg---skryPFYKSAAGHGTEMAKLIRrvcPKIELYVAKlg 910  Chaetomium gl...
EED47274      802 RGEPIVVAVIDDGVDIeqMDLKkygs---itgRSFCpqphd--pkfkiPHYNSSRGHGTLMAKQIHricPKANLLVLKle 876  Aspergillus f...
XP_002145934   15 NAAPIKIAIIDDGIDA--TIPDiqrr--iavgKTFSpypns--tefmnAYFVPRGLHGTLMARLICkicPKPKLFVARle 88   Penicillium m...
Feature 1                            #                  #                                         
XP_001398722  150 dgvsyanpsspsrtihpdSAAHAVEVAIKhNVDVISMSWTLRkrisefrssdpg----slgkksidepgiERLEKAIKEA 225  Aspergillus n...
XP_001903856  290 dyhhped--pnlrliaarSAVKAIRAAVGkEVNINSVSWTIEptgt---------------------egdQNLELAIADA 346  Podospora ans...
XP_659798    1102 srpsfihg-drarsinakSAADAINAAVMhGADIISMSWTITdleyrlslisenmsdaegnkkhaeqndlQLLRTAIAEA 1180 Aspergillus n...
XP_380297     863 tqpskgg---qhltidesSISPAIEAALEkNADVISMSWTIPipvtg-------------------sdnqKRIDNVLKLA 920  Gibberella ze...
XP_963595     368 dlpskn----gnreittqSAVKAIKKAVQkRVDIISMSWTIDvdes--------------------dpakNDLEEAITSA 423  Neurospora cr...
EAQ93755      720 tyenykr---ntrdidagYAAQAIQAALDkRATIICMAWAIPi--------------------------aEGEAEEIKQP 770  Chaetomium gl...
XP_001209101  501 kgra---------didpkKAAKAIHWAVEqKVDIISMSWVTKkn-------------------------eEELEKAVKEA 546  Aspergillus t...
EAQ88708      911 dwtdqerverlgevstaeNAAKAVDWAIRrHVHIISMSWSLVkvdan-------------------keqiALLDSKIQEA 971  Chaetomium gl...
EED47274      877 drddret---nkrcitpiSAANAIRYAVQrKVHIISMSWSIRapavnn-----------------isdefNELRGALQEA 936  Aspergillus f...
XP_002145934   89 erladd----gssrftpeSAVQAIEWAEAcGVDIISMSWTIEtrqe--------------------tgeiKQLKKIINEV 144  Penicillium m...
Feature 1                             #                                                           
XP_001398722  226 VD--------NNILMVCSAADDIellgk-dnlpFCAAEHNIFRIGSCNsqaQRDPITENRETISYFLPGIQVPearrp-- 294  Aspergillus n...
XP_001903856  347 AQ--------RGILMFCSASDRGakqn--atypSKAAPGRIFTIGAASvwrNAVASVGSLDRITFILPGEKVSvpgse-- 414  Podospora ans...
XP_659798    1181 VKn-------NKRLLICSAADDIrlvgd-ntlpYSEASGQILCIGSTGplaNRDPGSGSENSITYYLPGNQVAeeqrp-- 1250 Aspergillus n...
XP_380297     921 CS--------KDVLMFCSSPDQRtqtk---hypSHYNREKIFLIGAADd--SGTAFNHSGLDNDFIFPGVNVNtgnnlgr 987  Gibberella ze...
XP_963595     424 SK--------LGILMFCSAKDNGadnr--qtypAKAASEKIFKIGAALesgVADEWVGDLRLLDFTFPGSKKEy------ 487  Neurospora cr...
EAQ93755      771 VE--------RNVLMFCSAYDGVftet---hypSGPWRDRFFCIGAVPv-dGSVFPWSAEDGITYMIPGVGVTqeleprd 838  Chaetomium gl...
XP_001209101  547 AQtdk---grRPTLMFCSTADEGafgg---payPVDYKEHVVSVSATDswgGLTSKTDRHTRVDVSIPGEDLEasapf-- 618  Aspergillus t...
EAQ88708      972 AR--------KGIIMYCAAADQGqygsdlelypARADTKHVKAVGSARe-nGAASTSVDPSQVEYLFPGEEIE------- 1035 Chaetomium gl...
EED47274      937 QN--------ANILLFSSASDQGpdty---dtyPAFGTSAIFKIGGADvdgNLHAQVGGEDNVHYIFPGDTFEgddnn-- 1003 Aspergillus f...
XP_002145934  145 GGengartgkPPIFLFASASDQGghig--dasyPGDLRPPCFRIGGSSe-rGEKLPWVNRDMVDFLLPGQRIPfhdr--- 218  Penicillium m...
Feature 1                              #                                       
XP_001398722  295 ---------hsvkPIVYHDGSSIATALAAGSISMILh-----CARYMAQCRGCQNSSQDGS 341  Aspergillus niger CBS 513.88
XP_001903856  415 ---------raslSFREPSGSSVATALGAGLAALMLy-----CVKVHLVLAKPGPEKERIQ 461  Podospora anserina DSM 980
XP_659798    1251 ---------qsakPVVYHNGSSVSTALAAGLASLIMy----cCQCLHSSGAGDEYKVWAQA 1298 Aspergillus nidulans FGSC A4
XP_380297     988 y-----hsndstsPVQMATGSSIATALAAGLAAMVTy-----CFKTSALAAVTTRIAQGRP 1038 Gibberella zeae PH-1
XP_963595     488 -------------NGMTIFGSSIATAYAAGLVALILy-----CVQVRLFLATSEADKMQAR 530  Neurospora crassa OR74A
EAQ93755      839 taaggdqripeskVQVQTTGSSIATALATGLAAMIIy-----CIKASILAAKTANASTGLP 894  Chaetomium globosum CBS 148.51
XP_001209101  619 ---------ylgnVGSTVSGSSVATALAVGIAPLALl-----LLRTYNDGSEDELSSFYTR 665  Aspergillus terreus NIH2624
EAQ88708     1036 -------------ELGKRKGSSAATALASGLAALVL------CCFEKQLGKGGSSRIANPK 1077 Chaetomium globosum CBS 148.51
EED47274     1004 --------dglasRSQWFTGSSVATAYASGFAALILy-----CAQVRIALSNENDRVKCTE 1051 Aspergillus flavus NRRL3357
XP_002145934  219 ----------ekdSFTYETGSSLATACAAGLAGLLLycervlGESNRIINRGKMEEAFQNL 269  Penicillium marneffei ATCC 18224

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