Conserved Protein Domain Family
Peptidases_S8_6

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cd07490: Peptidases_S8_6 
Peptidase S8 family domain, uncharacterized subfamily 6
This family is a member of the Peptidases S8 or Subtilases serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.
Statistics
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PSSM-Id: 173815
View PSSM: cd07490
Aligned: 6 rows
Threshold Bit Score: 305.627
Threshold Setting Gi: 145596266
Created: 20-Nov-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
active sitecatalytic triad
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                #                                      #                                 
CAB86111      220 GVTVAVLDSGVDAGHPDLagriaqsrsf-------ipgeevadrhGHGTHVTSTVGgsgaasdgkeKGVAPGATLAVGKv 292  Streptomyces ...
ZP_01621643   158 GVKVAVLDTGVYSDHPALkdrvkdfiivdpn-grrisatpyfdagQHGTHVCGTIGggktd-kgvsIGVAPEVDLLAGGv 235  Lyngbya sp. P...
YP_737722     228 GVTVAVLDTGYDVQHGDLagqvlqskdft------yssngvddlnGHGTHTAATIAgtgvesnslwAGMAPGAKLLVGKv 301  Shewanella sp...
ZP_03696193   172 GAEIAILDTGVDPDHPDIdiedenwaefdedgeqvdsdpyeshsnGHGTHVSGTATggna--sgeyIGVAPEADLMHGLv 249  Natrialba mag...
YP_331041     196 GARVAVLDTGVNASHPDIelapngwadfdla--gnridsephdgdGHGTHVSGTVAgd------ngIGVAPDAELFHGRl 267  Natronomonas ...
YP_001160563  259 GVTVAVLDTGVDATHPDLigkiaearnfte----tpdahdtvghgTHVASTIAGSGvasd---gryQGVAPDATLLDGKv 331  Salinispora t...
Feature 1                    #                   #                                  #             
CAB86111      293 lddegfgseseIIAGMEwaardvdaDIVSMSLGstepsdgtdpmAEAVNTLSre--tgALFVIAAGNTgapssigSPGAA 370  Streptomyces ...
ZP_01621643   236 ligd--atlqtLIEGMAwaie-kgaSVINMSLGltyy---eplfAEVFDMLLnq--fnVLPVVAIGNEnhg-ntsSPGSA 306  Lyngbya sp. P...
YP_737722     302 ltnsgagstsgILSGMQwavs-qgaDVVSMSLGgsgts-ctgplVDMVEALSd----kALFVVSAGNSftretvgIPGCA 375  Shewanella sp...
ZP_03696193   250 ldags-gslaqIIGGIEwave-edaDAVSMSLGvsaye--eafiEPQMNALDa----gTLVIASSGNDgeg-sssSPGND 320  Natrialba mag...
YP_331041     268 dddg--atfsqLTAAMEwavk-hdaDVISISLGgds------rtHQYVEHIQnahasgSLVVSSAGNNgpg-tstSPADV 337  Natronomonas ...
YP_001160563  332 cqdvg-cpesaILAGMQwaavdkraDVVNMSLGgwdsp-eidplEEAVGALTaq--tgALFVVSAGNAggdgtvgSPASA 407  Salinispora t...
Feature 1                                                                                      #  
CAB86111      371 DAALTVGAVdsadqaawft--------------sagprygdnaLKPDLSApgvgilaars--rlaegsgdyTSMDGTSMA 434  Streptomyces ...
ZP_01621643   307 HNAFSIGALekypndelgiaffss----gaslvfpedspnkwvTKPDVAApgtqvyscippvqqpngiyqyTYMDGTSMA 382  Lyngbya sp. P...
YP_737722     376 PSALTVGAVdrdnntasfs--------------srgpspdghsAKPDIASqgvdvvsaa---sggfgatayRALSGTSMS 438  Shewanella sp...
ZP_03696193   321 YDSFAIGATdesediaqfssgewidt-qiawgsdapdhwpeeyVVPDIAApgvgvns-------aqpdgeyDTLSGTSMA 392  Natrialba mag...
YP_331041     338 YPVLSVGATsqdgeqiwpessgeqvfksewdtdeipstwpdeyVVPNVVApgadvrs-------asadggyERKFGTSMA 410  Natronomonas ...
YP_001160563  408 DAALAVGAVdredeladfssrg---------pragddalkpdiTAPGVDIvaarsahgr---igepvgehyARLSGTSMA 475  Salinispora t...
Feature 1                                          
CAB86111      435 TPHIAGVAALLaeehpd-wsgarLKDALMSTSK 466  Streptomyces coelicolor A3(2)
ZP_01621643   383 TPHVAGVVALLmsacpk-aplsaIMKALEETAY 414  Lyngbya sp. PCC 8106
YP_737722     439 APHVSGGAAIVmqarpd-lsprqIKEVLTSSVV 470  Shewanella sp. MR-7
ZP_03696193   393 APHVAGTVGLMaaaseddlspeqYETAMTAHAW 425  Natrialba magadii ATCC 43099
YP_331041     411 VPHASGVAALLaataseelspeaTRDVLAETTD 443  Natronomonas pharaonis DSM 2160
YP_001160563  476 APHVAGAAALLaqqhpd-wtaeqLKSTLMAAAR 507  Salinispora tropica CNB-440

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