Conserved Protein Domain Family
Peptidases_S8_2

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cd07488: Peptidases_S8_2 
Peptidase S8 family domain, uncharacterized subfamily 2
This family is a member of the Peptidases S8 or Subtilases serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.
Statistics
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PSSM-Id: 173813
View PSSM: cd07488
Aligned: 7 rows
Threshold Bit Score: 221.959
Threshold Setting Gi: 15829126
Created: 26-Sep-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative activeputative
Feature 1:putative active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                #                                    
YP_278168  61 FNNKKYFDKNITFVGs---sTQNTGTIhrnwwf---ygptpsNHATLVGSIAAGLDG---------VNPYLDKFSlvl-- 123 Mycoplasma synovia...
AAZ44421  262 ADMSGTFDENDAKKAeleynEIHYFNIgrapqek--lkddqnDHATLVSGIIGGRSGfsrgsdmfiVNLAKANFD----- 334 Mycoplasma hyopneu...
NP_852879 232 NDSKALIDAIDPYYFdp-kiTNVRNRWdlfwrdg-frslqygNHSTKVGSIISGTNG---------VNLYHDLYGvkyna 300 Mycoplasma gallise...
AAZ44179  217 VTDEFNYNFMSYFNAn---nFHINDLGstnkwneqkegqkepYHSTLVSLILGGKLGid-----tkSTPYLSIFGi---- 284 Mycoplasma hyopneu...
NP_326486 175 NVKLGIYDDGKISPNp---lLFDKEWItnkerfw-wfnntfgEHATNVASVAGGYKG---------VNERIKLYGikr-- 239 Mycoplasma pulmoni...
NP_484824   5 RPGMFGWDKAVSKNRa---vSLAAVFLrngpak---snngvdPHAYNVAGVMVSRDKglpg-vapaAKLYSSAVGst--- 74  Nostoc sp. PCC 7120
NP_443004   5 RPVQYLWDKLGGWQPp---yRLTGVFHlnqisp---rnrffdDHAGMVAQAMVSRDKrypg-vapeARLYSTAMGpl--- 74  Synechocystis sp. ...
Feature 1                 #                          #                                        
YP_278168 124 ---------nstNGTWQEYnwv------eaKKTDILNMSYGlkaklg--------------------rykydsDSHDVTK 168 Mycoplasma synovia...
AAZ44421  335 ------------SPIWMTVferl----iieYRIKIINHSYGfnsiskrdieasfeniynldsimensvvqyidHIFYLDF 398 Mycoplasma hyopneu...
NP_852879 301 fdfnavhsgtaySGLENEIdyi-----krlNNLKIVNNSWGvrnsnsip----------------eawysynfYSRYIDL 359 Mycoplasma gallise...
AAZ44179  285 ------------NSQWQKAiewm----vktNNVKVINHSYGggkkef---------------------ydydeDSFFLDF 327 Mycoplasma hyopneu...
NP_326486 240 ---------fnwNGISQEIewl------msNGVKVINMSFGlgpgn-----------------------kyneYANYLDQ 281 Mycoplasma pulmoni...
NP_484824  75 ----------knMGQPEEClsaqhiasqngGDVRAINFSFGeplnrdprp--------------eavldgnalLTLCVDW 130 Nostoc sp. PCC 7120
NP_443004  75 ----------seNLQPQQClagqfvsrqdgSNIRAVNLSYGeslerdarg--------------daqldgnalLTLCLDW 130 Synechocystis sp. ...
Feature 1                     #                                                               
YP_278168 169 LAYEn-kELIIVRSAGNDGaetd------pnkRYINGGSLASNIIVVGSNNRYghrsft--------------------- 220 Mycoplasma synovia...
AAZ44421  399 LSRKy--GVINIFAAGNEYddkwknnnsakkyGYISGYANALNSIVVGSTFGTkdnffasnfs---------------nr 461 Mycoplasma hyopneu...
NP_852879 360 VTANe-rEMIYVFSAGNNGnla-------qkfKKLSRYQLAYNTIVVGSNDYNgkkssl--------------------- 410 Mycoplasma gallise...
AAZ44179  328 LARKy--GVINVFAAGNGAreysde--eyedhPWIDAWSLSLNSIVVGALDDNsepwkiaknkia----------dysny 393 Mycoplasma hyopneu...
NP_326486 282 LQNNknnEVTIVTSAGNDAiyk-------ekdHNLQQNKLSYNSIVVGALDHNdfskvasy------------------- 335 Mycoplasma pulmoni...
NP_484824 131 SSRV---HDVVYAIAGNQGk------------GGIPIPTDNFNGINVAFSSRRegifnkvdvsnlagvn---qgvsgrla 192 Nostoc sp. PCC 7120
NP_443004 131 LTQQ---QNLLFVVAGNQGt------------GGIAIPTDNYNGITVAYTVQSadrqgrydrmaftnlsrqpegmgkriv 195 Synechocystis sp. ...
Feature 1                                         #                                           
YP_278168 221 -snygsyTGRQVTLLANGeyyfn---nnedGYNSGTSFSAPFISGILSLMLRKYrnvy----dlghNNLIALSTLSASTY 292 Mycoplasma synovia...
AAZ44421  462 llpyrlnQLPKPLISAPGenitg--iigqkFPVSGTSFSAPIVTGIISTIDSLYswmf-----ndkNFIPAIMSLLSSSA 534 Mycoplasma hyopneu...
NP_852879 411 -ssigsyNTNVPLILANGsnys-----fknDFSSGTSFSAPFISGILANTLIQYkeky----klgiNSIIAKAALGVSSK 480 Mycoplasma gallise...
AAZ44179  394 ktgqqyyELAKPLVVAPGriynpvtnrskdDFVSGTSFAAPVVTGLISTLLREKpnld-----nddNRLIALKAILSASA 468 Mycoplasma hyopneu...
NP_326486 336 snygsfsGGKSVTLSTPV------------PILSGTSFSSPLVAGVIASLMNKKeqiy----kkglDNLISLSALSSSST 399 Mycoplasma pulmoni...
NP_484824 193 gkefnidGRRAVSIVAPGsninllnpdgklNKVTGTSFAAPHLTATVALLQEFGdrqlr--tkkpnWSIDSRRQQVMKAV 270 Nostoc sp. PCC 7120
NP_443004 196 ereinqgRRQGVSLVAPGsdfylydmkgrvEWVSGSSFASPLVTGTVALLQEFGdrqllvntnssrWNLDARRPMVMKAV 275 Synechocystis sp. ...

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