Conserved Protein Domain Family
Peptidases_S8_1

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cd07487: Peptidases_S8_1 
Peptidase S8 family domain, uncharacterized subfamily 1
This family is a member of the Peptidases S8 or Subtilases serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.
Statistics
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PSSM-Id: 173812
View PSSM: cd07487
Aligned: 39 rows
Threshold Bit Score: 259.825
Threshold Setting Gi: 113867709
Created: 9-Sep-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
active sitecatalytic triad
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                 #                                                                      
NP_389608    146 GKGVTVAVVDTGIy---PHPDLEGRIIGFAdmvn---------------------------------------------- 176 Bacillus subtil...
YP_873147    167 GAGVTVALIDTGVs---DTPALDRASGRLVdavdtsglnt---------------------------------------- 203 Acidothermus ce...
YP_873662    152 GQGIGVALIDSGVv---PVPALSAPGKIIYgpdftpt------------------------------------------- 185 Acidothermus ce...
YP_267503    133 GDGVTIGFLDTGLd--qLEGTSNGLGLSTDlygrdkfwgty--------------------------------------- 171 Colwellia psych...
ZP_01625171  242 GSGIGVAIIDSGLwdipALTHNALGELRIAthynair------------------------------------------- 278 marine gamma pr...
ZP_01101900  261 GRDITVAVLDSGLweanAELTLDTQGKERVlarydai------------------------------------------- 297 Congregibacter ...
YP_663100    281 GKDVTVAVIDSGLw--aAHSALGNDTANNTrikaaydal----------------------------------------- 317 Pseudoalteromon...
YP_001546351 138 GRGVTVAVIDSGLpa-iERPERWQRIDNTTarynqgsrfliy-------------------------------------- 178 Herpetosiphon a...
YP_001213666  94 STGLTVAVLDSGIr--kSHEALQNKVVYEAnltd---------------------------------------------- 125 Dehalococcoides...
CAP62836     304 GQGVRWAVIDSGVd--aRHPAFFDPLKLDGplpvrdgliaprlsrvvrtldftrlsaitsgrlppmpkgkrgpgeaelrq 381 Cupriavidus tai...
Feature 1                                                #                                       
NP_389608    177 ------------------------------qktePYDDnGHGTHCAGDVAssgass-----------------sgqyrGP 209 Bacillus subtil...
YP_873147    204 ------------------------rgghvvengtFTDGyGHGTFMASLIAggvvdg----------------tngtalGV 243 Acidothermus ce...
YP_873662    186 ---------------------------gyftevrGLDTfGHGTFMAGLIAgrdpgatap----------ywansgyylGV 228 Acidothermus ce...
YP_267503    172 ------------------------dainnnlsnySNEEsGHGTHVASIAGnadydv-----------------ygkvyGV 210 Colwellia psych...
ZP_01625171  279 ----------------------------dqidlnLRDEgGHGSHMASIIAnsqrvan--------------rdpaqfqGL 316 marine gamma pr...
ZP_01101900  298 ---------------------------agvemdeAFDAsGHGTHMTSVLArsgevtrd------------gtarpsyrGI 338 Congregibacter ...
YP_663100    318 -------------------------edtelnvsnLTDEnSHGTHITGIIAnsdravvd------------gqmrsyyqGV 360 Pseudoalteromon...
YP_001546351 179 -----------------------kdmlasnqitnSSDPyGHGTHVFATLAdnralpa--------------gysgakvGI 221 Herpetosiphon a...
YP_001213666 126 -------------------------------spsATDIfGHGTQVAFIIAggfha------------------igskaGV 156 Dehalococcoides...
CAP62836     382 rvaaiaddlshgriidwsvieplldishddpaqyVPPGgSHGTHVAGIIGagwpssvylarpdpmplpselaesgdvsGI 461 Cupriavidus tai...
Feature 1                              #                                 #                       
NP_389608    210 APEANLIGVKVLNKQGSGtladIIEGVEWCiqyned--------npdepiDIMSMSLGgdalry-dheqeDPLVRAVEEA 280 Bacillus subtil...
YP_873147    244 APGATVDVVKVADDTGRSslaaVIAGLNWVatha-------------nsvDVANLSMSvtppt--sgygiDPLNFAVTLT 308 Acidothermus ce...
YP_873662    229 APDANIISVKVADASGATmasaVIAAIQWVvahrnd---------pglniKVLNLSLGvrdgl---pyqqDPLDAAVEAA 296 Acidothermus ce...
YP_267503    211 APNASLVGIKAFDAEGKAtyadVIRGIEWAlqvkd-----------qinlRVLNMSFSgpars---yyweDPLNQAVMKA 276 Colwellia psych...
ZP_01625171  317 APNAVLIPVTAISPRGDGdfmdIIRGIQWVtnnqa-----------hfniRVLNLSLTatprs---eywaDPMNQAVMEA 382 marine gamma pr...
ZP_01101900  339 APDAKLVVVKAFDESGKAgfldIVRGVQWVvdnre-----------rlniRVLNLSFAarprw---pyweDPVNQALMQA 404 Congregibacter ...
YP_663100    361 APDANLVVVKAFYEDGHStyldALRGLQYIadnhe-----------alniRVVNLSFGapprs---nywdDPINQAVMAL 426 Pseudoalteromon...
YP_001546351 222 APGANYVVVRALNSQGQAsystIIAAIDWViehad-----------eydiRVLNLSLQaevia---pywyDPLNQAVMHA 287 Herpetosiphon a...
YP_001213666 157 SPGAALMNIKVISDEGIGndedIVLGIDRVcelaeearekglwptddlypNVINLSLGaedd----gdpdNPVRSACRKA 232 Dehalococcoides...
CAP62836     462 CPRIELLDLRIFDAQGRGdefgILGALQYVrwlnqs--------rdrqsvHGINLSVAlrhdvrsyacgsTPVCVECDRL 533 Cupriavidus tai...
Feature 1                     #                                                                  
NP_389608    281 ws-aGIVVCVAAGNSGPdsqt-------------iasPGVSEKVITVGALDdnntassd-ddtvasfSSRGPTVYGKEKP 345 Bacillus subtil...
YP_873147    309 ry-aGVTVVVASGNTPGvv----------------gdPGFSPDALTVGAADttgdt------pvvasFSGYGNVDGIVKP 365 Acidothermus ce...
YP_873662    297 wk-aGITVVAAAGNDGQvgm---------------taPANDPYVIAVGAIDtnstls----vsddtvASFSNIGDGTRNP 356 Acidothermus ce...
YP_267503    277 wq-aGIVVVASAGNSGPdpmt-------------igvPGNVPYIITVGAMTdnftesdpnddklatfSAAGPTFEGFVKP 342 Colwellia psych...
ZP_01625171  383 wk-aGITVVVAAGNDGPdwgt-------------igsPGNNPYVITVGAFTdswtpgdrrddyipnfSSRGPTPEGFIKP 448 marine gamma pr...
ZP_01101900  405 wk-aGIFIAAAAGNEGPepmt-------------vgsPGNLPYLLTVGAVTdswtedirdddyipdfSSRGPTPMGHIKP 470 Congregibacter ...
YP_663100    427 we-kDVIVVTSAGNTGPsamt-------------igvPANVPYVISVGAISdnytqdnanddtllsfSSQGPTHEAFIKP 492 Pseudoalteromon...
YP_001546351 288 wn-eGITVVAAAGNTGPnpat-------------imaPANVPYIISVGAIRpaiyndng-sdslaaySSAGPTESRFVKP 352 Herpetosiphon a...
YP_001213666 233 steyGLDVIAAAGNSGPkmtt-------------vmlPACDPEVIAVGAVEttgdl------viwekSSRGPTMQGETKP 293 Dehalococcoides...
CAP62836     534 va-sGVIVVAAAGNYGYdeafaaehmgagfrgqtitdPGNARAVITVGATHrtdpyr----fgisyfSSHGPTGDGRIKP 608 Cupriavidus tai...
Feature 1                                                             #                          
NP_389608    346 DILAPGvniislrspnsy---------------idklqkssrvgsQYFTMSGTSMATPICAGIAALILqqnp--dltPDE 408 Bacillus subtil...
YP_873147    366 DVVAAGvnilgempadtv---------------iaqqfpngrqpnGLFRGSGTSQSTAIVSGLAALYLqahp--hanPWV 428 Acidothermus ce...
YP_873662    357 DFVVPGthivglrdpgsai-------------dqeygngpgsinaSLMRGSGTSEAAAITSGAVALLLsqrp--nltPDQ 421 Acidothermus ce...
YP_267503    343 EIVAPGghlsglmaydsq---------------ivqehpefhdggRYFEMSGTSQAAGVVSGVVALMLtqdp--altPDQ 405 Colwellia psych...
ZP_01625171  449 DFVAPGghisglippdst---------------laienpnyfltsGEFVSTGSSQAAAVVSGLIALLLeikp--elsNDD 511 marine gamma pr...
ZP_01101900  471 DLVAMGghisgiirpgst---------------lsqqlpeyllqsGEFVMTGTSQATALVSGLVTLMLqisp--elnNDE 533 Congregibacter ...
YP_663100    493 DMVAPGghmfslanedmy---------------vpakypqymvgkDRFIMSGTSQASGVVSGVVALMLqddp--slsAND 555 Pseudoalteromon...
YP_001546351 353 DVVIAGsrviaplpadsvlansgsaglvseraklewadlktsqqlNYYALSGTSMAAAEVSGIVALLLqdep--nltNNQ 430 Herpetosiphon a...
YP_001213666 294 DFVIWGtnlema---------------------------shkaddEYLTKSGTSFAAPMISGLTGLLWesg----rrAYG 342 Dehalococcoides...
CAP62836     609 DLVAPGekits-----------------------------tvpggTLASMDGTSMAAPHVSGVAALLLsrnnelmgqPET 659 Cupriavidus tai...
Feature 1                  
NP_389608    409 VKELLKNGTD 418 Bacillus subtilis subsp. subtilis str. 168
YP_873147    429 VKSAIRNAAT 438 Acidothermus cellulolyticus 11B
YP_873662    422 VKATLVIHSS 431 Acidothermus cellulolyticus 11B
YP_267503    406 VKCRLMDSAH 415 Colwellia psychrerythraea 34H
ZP_01625171  512 VKCLLLTSAQ 521 marine gamma proteobacterium HTCC2080
ZP_01101900  534 LKCMLLTSAE 543 Congregibacter litoralis KT71
YP_663100    556 VKCRLMTSTT 565 Pseudoalteromonas atlantica T6c
YP_001546351 431 IKARLTGTAQ 440 Herpetosiphon aurantiacus ATCC 23779
YP_001213666 343 ESWQFRWTDA 352 Dehalococcoides sp. BAV1
CAP62836     660 VKTILCAAAT 669 Cupriavidus taiwanensis

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