Conserved Protein Domain Family
Peptidases_S8_12

?
cd07480: Peptidases_S8_12 
Peptidase S8 family domain, uncharacterized subfamily 12
This family is a member of the Peptidases S8 or Subtilases serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.
Statistics
?
PSSM-Id: 173806
View PSSM: cd07480
Aligned: 17 rows
Threshold Bit Score: 298.134
Threshold Setting Gi: 111022386
Created: 28-May-2009
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
 
active sitecatalytic triad
Feature 1:active site [active site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                       #                                   #                            
AAW57022     162 INSKYSGAGIKVAVLDTGLDLKHPDFVGRAiTSESFIKGEa----vQDLNGHGTHCIGTACGpfnppapaspmryGIAYN 237 Cyanothece sp. ...
YP_767461    179 IESDLSGAGIKVAILDTGFDETHQDFVGRSvTKKLFATRSs----eGDVHGHGTHCIGTACGplrpt---sgpryGIAHE 251 Rhizobium legum...
NP_826886    176 NMSSLTGRGVKIAVLDTGVDTDHPDLAGRIdETVSFVPGEt----vEDGHGHGTHCIGTAAGpaspq---qgpryGVASE 248 Streptomyces av...
YP_001611169 105 HATNFTGQGVRVAVLDTGIDRTHPAFAGKDiTSRDFTGEGsspedvSDYDGHGTHCAGTICGasvd-----girvGVAPG 179 Sorangium cellu...
YP_001202966 105 TAALDDGAATTVAILDTGIDASHAAFKGVDlRRENFSNSSn----dGDANGHGTHCAGTIFGrdvd-----gvriGIARG 175 Bradyrhizobium ...
CAJ50219      77 DVSPFTGQGVKVAVLDTGIDSKHPAFKGIDlTEQDFSGSGn-----GDRNGHGTHAAGTIFGrdvd-----gtriGVARG 146 Bordetella aviu...
ZP_01443306  103 DTSAFTGAGVRVAVLDTGIDTNHPAFAGVAlNTRDFAGSGi-----EDANGHGTHCAGTVFGrdvd-----gnriGVARG 172 Roseovarius sp....
YP_001943935 141 VGSSCNGEGIVAAVLDTGIDPGHQAFAGVElVRKNFTDESd-----DDEHGHGTHCAGTIFGrdvd-----gmriGVAPG 210 Chlorobium limi...
YP_303823     95 SESPFDGTGVTVAVLDTGIDPNHPAFKGMKlVQKNFTTEId-----NDIHGHGTHCAGTIFGqdvn-----gvriGIARK 164 Methanosarcina ...
YP_351425     92 DRSPFTGADVTVAVLDTGIDKSHPAFAGMDiVEHDFTGEGn-----GDVNGHGTHCAGTIFGrdvn-----gqriGIARG 161 Pseudomonas flu...
Feature 1                            #                   #                                       
AAW57022     238 AEIFAGKVLSNQGSGPDGG-ILEGISWAIANNC-DIISMSLGart-------------fpGDPFPRSYERIAQRa----- 297 Cyanothece sp. ...
YP_767461    252 AEIYAGKVLGDDGFGTDRS-IIAGMEWALDEGC-HVISMSLGaat-------------qiGDAPSDDYEQIGQVc----- 311 Rhizobium legum...
NP_826886    249 ARVLAAKVLSNAGSGTDGQ-ILAAMAWAVAHGA-RVISMSLGaav-------------qpGELFPQTYEQLAQRa----- 308 Streptomyces av...
YP_001611169 180 VTKIAVGKVLGTNGGSLEM-LLKGMLWAVFEQKaDVVSMSLGydlpgnv-----qrlidrGMDARRASYAAMQLqndiik 253 Sorangium cellu...
YP_001202966 176 VRKALIGKVLNDEGRGDTAiFARATQWALDNGA-RVISMSLGfdfnalfed-lkakgnprAQAFSMALSHYRDTvrlfds 253 Bradyrhizobium ...
CAJ50219     147 VSQALIGKVLGDDGTGGSGmIFDGVLWALRNQA-SIVSLSLGldfpglvar-ltqqgwpvDLATSEALIAYRSNmrlfda 224 Bordetella aviu...
ZP_01443306  173 VTDALIGKVLGDDGSGSSDmLFRAIKWASDEQA-QVISMSLGfdfpglves-lvdqgwptLLAGSAALEAYRQNlrmfda 250 Roseovarius sp....
YP_001943935 211 IKKALIGKVLGNSGGGSDK-IIEAIQWAVSNGA-NVISMSLGmdfpgyvka-ledeglptEHATSMALEGYRTNillfqs 287 Chlorobium limi...
YP_303823    165 IKCALIGKVLGKEGGSSDT-IAKAIQWAVQEGA-NVISMSLGidfpgyvdwlvhdqgmniNPATSQALEEYRANvnlfte 242 Methanosarcina ...
YP_351425    162 VSRAVIGKVIGQNDGDSQM-IFEGLQWALQQRA-NIISMSLGfdfpgevqs-kvndgwpvDLATSQALETYRGNlrllda 238 Pseudomonas flu...
Feature 1                                 #                                                      
AAW57022     298 -----------LRRGTLIIAATGNESSRPGFISPVGRPancpSIMGVAAVHPDLgvsfy-sngaiNPNGGEVNIAGPGgn 365 Cyanothece sp. ...
YP_767461    312 -----------LDAGTLVVAAAGNESSRPQQIAPVGSPanasTILGVGAVDRSFvpasf--scggLNPGQEVDIAAPGvd 378 Rhizobium legum...
NP_826886    309 -----------LQRGTVIVAAAGNESSRPQAIRPVGRPancpSILAVASLDRALtvssf-ssagiNGQGGEVNIAAPGra 376 Streptomyces av...
YP_001611169 254 gvsklrgflesQAKNVVFVAATGNESDRAAGVVLGAGLpa-sELFGVGAVGPTDatgdk--wkiaDFSNGRALVVAPGvd 330 Sorangium cellu...
YP_001202966 254 iiqtlnasgivLRTGAVVVAAAGNESQRRETPPCIVDVslpaAAEGVVSVGAVEkstng--fevaSFSNANAKLWAPGvg 331 Bradyrhizobium ...
CAJ50219     225 mm-gllqaqgpFEGTPLVVAAAGNESRRQINRNYRIGVslpaAANSVLSVAAVGrqgkl--fgvaPFSNEMATLSAPGvd 301 Bordetella aviu...
ZP_01443306  251 lm-dmlraqaaFSGGTVVCAAAGNESRRNIDPTFEVSAslpaAAFGVVSVGALGqgpgg--lniaSFSNTNPTVSGPGvn 327 Roseovarius sp....
YP_001943935 288 ma-alvasqemFGKTSLLIAAAGNESQRPAFEIAVSPPa---VSNGFVSVAALGrtpagktwsvaDFSNTGARLSGPGvd 363 Chlorobium limi...
YP_303823    243 lv-rvvaahgaFGQSAIIVAASGNESNRPKYEIAVSPPa---AATGIVAVGALNksgkg--fnvaEFSNNQVNIAAPGvn 316 Methanosarcina ...
YP_351425    239 lm-glfkaqsaFNLAPLVIAAAGNESRRMINSQYKIAAslpaSAQDVISVAAVSpamqi-qyevaDFSNSFPQLSAPGvd 316 Pseudomonas flu...
Feature 1                                                #                                       
AAW57022     366 agqpplpeiystystdtipqmtpfgidpnpPSRYKAISGTSMATPHVaGIAALYAESTGKRGMDLWNVLIa--------- 436 Cyanothece sp. ...
YP_767461    379 if------------------------sslpDDKYDRWDGTSMATPHVaGVAALIAQSDPKFRGWALWARLi--------- 425 Rhizobium legum...
NP_826886    377 vh------------------------saapGGGYQSMSGTSMATPHVaGVLALLAQAAPNASAEDLKASLl--------- 423 Streptomyces av...
YP_001611169 331 vv------------------------saavDGGWATMSGTSMATPHVaGVAALWVHKLREAGMLNIPGTVeaelrk-stt 385 Sorangium cellu...
YP_001202966 332 iv------------------------sarvGGGLAVSQGTSMAAPHVsGAAVLWSEWLARRNPRSGPAELkarltasarv 387 Bradyrhizobium ...
CAJ50219     302 its-----------------------aragGTGLATLSGTSMACPHVsGVAALWHEFLVQAKSQPSAANVmarlkasarn 358 Bordetella aviu...
ZP_01443306  328 vi------------------------saatGGGLRPLNGTSMACPHVaGIAALWWEAQRASGSPAFAGAVqarlmatcts 383 Roseovarius sp....
YP_001943935 364 iv------------------------sakpGGGLTLMSGTSMATPHVaGVAALWGQKLLGEGCLRATLLIdrlvgn-ast 418 Chlorobium limi...
YP_303823    317 iis-----------------------akagTSGLISMSGTSMATPHAaGIAALWAQRQLKLTGRINNVSLmaqliasgtf 373 Methanosarcina ...
YP_351425    317 iv------------------------sawpGGALRSSDGTSMACPHVaGVAALWWQRAVESKSTNRAWAVaanlttharp 372 Pseudomonas flu...
Feature 1                             
AAW57022     437 --NAKTLPLPVTDVGVGLVQA 455 Cyanothece sp. ATCC 51142
YP_767461    426 -qLTKPLSSPGRDVGKGLLQA 445 Rhizobium leguminosarum bv. viciae 3841
NP_826886    424 -sSAFPLTQPVRDVGSGLLQA 443 Streptomyces avermitilis MA-4680
YP_001611169 386 raPLVDNDLDAIGTGLIQAPA 406 Sorangium cellulosum 'So ce 56'
YP_001202966 388 tgFSPTVADAERGSGLIQAPP 408 Bradyrhizobium sp. ORS278
CAJ50219     359 gvFVEGTDSADVGLGLVTAPT 379 Bordetella avium 197N
ZP_01443306  384 apIDPATDALDRGQGLVQAPA 404 Roseovarius sp. HTCC2601
YP_001943935 419 kgMKKGFDPSDIGAGMVMAPQ 439 Chlorobium limicola DSM 245
YP_303823    374 dsLVPGSEEDDVGTGIIQAPL 394 Methanosarcina barkeri str. Fusaro
YP_351425    373 ncFTSSFDASDFGHGLVTAPL 393 Pseudomonas fluorescens PfO-1

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap