Conserved Protein Domain Family
Peptidases_S8_thiazoline_oxidase_subtilisin-like_protease

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cd07476: Peptidases_S8_thiazoline_oxidase_subtilisin-like_protease 
Peptidase S8 family domain in Thiazoline oxidase/subtilisin-like proteases
Thiazoline oxidase/subtilisin-like protease is produced by the symbiotic bacteria Prochloron spp. that inhabit didemnid family ascidians. The cyclic peptides of the patellamide class found in didemnid extracts are now known to be synthesized by the Prochloron spp. The prepatellamide is heterocyclized to form thiazole and oxazoline rings and the peptide is cleaved to form the two cyclic patellamides A and C. Subtilases, or subtilisin-like serine proteases, have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure (an example of convergent evolution).
Statistics
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PSSM-Id: 173802
View PSSM: cd07476
Aligned: 12 rows
Threshold Bit Score: 306.948
Threshold Setting Gi: 115522787
Created: 8-Oct-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:putative catalytic triad [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                          #                                                              
AAY21156      531 DLHNQTLGDPQITIVIIDGDPDytLSCFEGAEVSkvfpywhepaepitpedyaafqsir--------------dqglkgk 596  Prochloron di...
ZP_01631555    12 QIWTRTKGDPRIKIAILDGAADleRSCFQGANFSqfqpywsedielneeyfyylnlslefnqqqkdkkddpdhdkeeakk 91   Nodularia spu...
YP_722058      12 KLWTHTKGDPRITVALLDGTADieRGCFQGANVTkinsywqeaieldpkdidtyreiqn-------------sdeksevk 78   Trichodesmium...
ACA04487        6 LRTLSLKGDHNIRVAILDGPVDiaHPCFQGYDLTvlptlap--------------------------------------- 46   uncultured Pr...
YP_001521427   17 DLWVETIGDPQISIAILDGFVDqsHPSLAEAKLTnletial--------------------------------------- 57   Acaryochloris...
YP_001007111   19 TLKNLGQSGKDIKIGIIDGLIErnHPLLNHINIHcsfi------------------------------------------ 56   Yersinia ente...
YP_779698      20 ILFAFGGGDPRVTIAVLDGPVDrtHECFRGARLVpveggar--------------------------------------- 60   Rhodopseudomo...
YP_484482      13 LLFAFGGGDPQITIAVLDGPVDrtHDCFRGARLApldtpaa--------------------------------------- 53   Rhodopseudomo...
YP_530600      13 LLFAFGGGDPRITIAVLDGAVDrtHECFRGARLTpldngss--------------------------------------- 53   Rhodopseudomo...
NP_950047      13 LLFAFGGGERNVTVALLDGLVDrtHDCFIGAPLKpintaaa--------------------------------------- 53   Rhodopseudomo...
ZP_01228789    22 LLDTLGACDPTLRIGVVDGTPDlaIPALADARLDleptmr---------------------------------------- 61   Aurantimonas ...
YP_002314062   18 DLWERTLGDPVVKIAILDGPTNlnHACLTDSNSRyisqr----------------------------------------- 56   Shewanella pi...
Feature 1                              #                                                          
AAY21156      597 ekeealeavipdtkdriVLNDHACHVTSTIVGQEHspvfGIAPNCRVINMPQDAVIRgnydd---------vmsplNLAR 667  Prochloron di...
ZP_01631555    92 ereaffapfppairqriELSSHATHISSTILGQHGtpapGIAPLCTALNIPISFAGDdfi-------------spiNLTH 158  Nodularia spu...
YP_722058      79 qaklkeaipdeitlqilGAAFHATHVFSNIFGQPGtpveGIAYKCRGINIPLGYGNDyyi-------------dpiNLAR 145  Trichodesmium...
ACA04487       47 ----------taarsdgFMSAHGTHVASIIFGQPEtsvpGIAPQCRGLIVPIFSDDRrri-------------tqlDLAR 103  uncultured Pr...
YP_001521427   58 -----------kasqqgSAAQHGTQIASIIFGQHQsllkGIAPQCRGLVIPIFADGNqqaidnnkfsetiapcsqlDLAR 126  Acaryochloris...
YP_001007111   57 --------------neeKKTTHGTAVCSIVGGKGL----GIAENVEIYNIPVFHEDSqgklq---------gcselTLAK 109  Yersinia ente...
YP_779698      61 -----------arspdsRAVARGSHSASVIFGQPCssveGIAPLCRGLSVPIFAGEDgca--------------sqGLAR 115  Rhodopseudomo...
YP_484482      54 -----------arcaeeFASAQGTHLASLIFGQPCssveGVAPLCRGLIAPIFGDDRpgc-------------sqtDLAQ 109  Rhodopseudomo...
YP_530600      54 -----------fhcpdgDTTASGSHAASVIFGQPCssveGVAPLCRGLIVPIFAEDGrgc-------------slrKLAR 109  Rhodopseudomo...
NP_950047      54 ----------qragddaPASAQATHLASLLFGQPCrsveGLAPMCSGLLAPIFSQNRsvc-------------gqaDLAD 110  Rhodopseudomo...
ZP_01228789    62 ------------iaeahGPDAHGTEICSVLFDREG----GLARGCSGLILPVFFPDPrpayma-------pratqtDIAR 118  Aurantimonas ...
YP_002314062   57 -------------psssIQSSHGTFITSLIAAKHSsevkGIAPACSFLLHDIYQEKPdgsly---------scsqsDIAA 114  Shewanella pi...
Feature 1                                                                                         
AAY21156      668 AIDLALElGANIIHCAFCRPt-QTSEGEEILVQAIKKCQDNNVLIVSPTGNNSNEsWCLPAVLPGTLAVGAAKvdgtpcH 746  Prochloron di...
ZP_01631555   159 AINTALQwGANIIHIAACHPt-QTGVAPDLFARAVKQCQENNMLIVAPGGNDKGEcWCIPSILPGVITVGAMRddgqpfK 237  Nodularia spu...
YP_722058     146 GINLAVDlGANIIHCAACRPn-QTGIGHEILEKAVRQAQENNVLIVAPTGNNKGEcWCLPAILPGVMSVGAMKdngqvfK 224  Trichodesmium...
ACA04487      104 GIERAVNaGAHIINISGGELt-DFGEADGWLENAVSLCRQNNVLLVAAAGNNGCDcLHVPAALPAVLAVGAMDerghplD 182  uncultured Pr...
YP_001521427  127 AILLAANqGAHIINISGGQLt-PSGAADPILTNAVRYCMENNILIVAAAGNEGCNcLHVPGALPSVLVVGAMSatgtplN 205  Acaryochloris...
YP_001007111  110 TINEARQqGCHIINISGASLs-VNGRGSDDLRKAVNNCQQAGILIIAAVGNEGINqESLPASLDSVLAVGACDkegypaK 188  Yersinia ente...
YP_779698     116 AIILALGhGAQVIHVGAGRFe-PSDDSDLLLTRAIAMCRRRNVLIVAAAGRDGCCdLEQAEWGASVLAVRALEdiglrqS 194  Rhodopseudomo...
YP_484482     110 AIVMALDhGAHILHISGGLFd-GRRQPTAELSAAVALCNDHNALIVAGAGRDGCAsLLRRCGAVNLLPVGAIDrn--grL 186  Rhodopseudomo...
YP_530600     110 AIFLAVEqGAHVIDVSGGQFa-RSERPDPVLAEAIEMCVRRNVAIVAAGGNEGCDeLLDLAEIAPVLAVFTLEyy---rR 185  Rhodopseudomo...
NP_950047     111 AITRSLDfGADIILIGAGAFe-RPWYPGFALADAVAKCNASNALIITSAGSKGCTtLLRRCGTLNLLPVAALDsv--gqL 187  Rhodopseudomo...
ZP_01228789   119 GIYMAVErGVAIVNISAGQLs-STPEASRHLEDALDLCERKGILVVAATGNDGCAcLHVPAAVASVLAVGAMDaagrplQ 197  Aurantimonas ...
YP_002314062  115 GIHNALEnGANIINISGGEPigSDVEMMPRLVNALQMCEQQGVLVVAATGNEGDArLHVPARFPTVLAVGSIDlqglpsG 194  Shewanella pi...
Feature 1                                              #                                          
AAY21156      747 FSNWGGNNTKEGILAPGEEILGaqpc-teepVRLTGTSMAAPVMTGISALLMSlqvqqgkpvdaeAVRTALLKTAIPCDP 825  Prochloron di...
ZP_01631555   238 FSNYGGEYQNKGVMANGENILGaqpg-teepIREKGTSCAAPIVTGISALLMSmqlqrgeqpnaeAVRQAILNSAIPCNP 316  Nodularia spu...
YP_722058     225 FSNWGGQYQQQGIIAPGENILGaqpg-teetVRQKGTSCAAPMVTAISALLMSlqlqqgaspdaeAVRAALTNSAIPCTL 303  Trichodesmium...
ACA04487      183 FSNWGSTYEQQGILAPGEDILGakpg--ggtERLSGTSFATPIVSGVAALLLSeqvrrgetpdpqKVRQLLLQSALPCDD 260  uncultured Pr...
YP_001521427  206 FSNWGEAYRTQGVLALGENIPGavlg--ggiTSSSGTSYATAIVSGIAALLLSlqvkrgqtpnpqAIRTAILQSALPCDD 283  Acaryochloris...
YP_001007111  189 FNNFGHKLRKKMLLAPGISIPVaitg--nniSLVSGSSFAAPIIAGFSALIIRalslngnnqaakVVNRLLFETATKLQP 266  Yersinia ente...
YP_779698     195 AVVPENDADRRVVAVPGANIVGaale--ggvGHRSGATGAAALLAGVVGVLLArqir----dgrsADPRAIREALLRAAA 268  Rhodopseudomo...
YP_484482     187 IGGSDASLHEIGIAVPGARLIGatle--ggiGERRGANYSAALIAGIAGLLLGtqtatgrahdpgAAIEAILGSATPRLA 264  Rhodopseudomo...
YP_530600     186 RLRSVDPIGMKALVIPGSNIVGaape--gdvTRRSCANGAAALVAGLVGLLLSrqlrrgaapdplAVRDFLLKFAGRHGP 263  Rhodopseudomo...
NP_950047     188 LGGQCRDLGDIGIAIPGTSVSGaale--grvVQRSNPNVAAGIVAGAAAVLLGvlcrvgarrdpgAVAEAIRMTATPRGA 265  Rhodopseudomo...
ZP_01228789   198 SSNYGASYGANGILAPGDGLTVsslr--gerVQRSGSSFATAVVTGVAARLLSaalragrpfgplDIRRILIETARPCDP 275  Aurantimonas ...
YP_002314062  195 FSNWTAADRLHGITTIGENIHGainqaeqlvGKMSGTSFSTALVSGVAALLAScqqqp---rdmlQIRDWILSCATPCLQ 271  Shewanella pi...
Feature 1                      
AAY21156      826 EVVEEPERCLRGF 838  Prochloron didemni
ZP_01631555   317 ETVEEPERCLLGK 329  Nodularia spumigena CCY 9414
YP_722058     304 EDTEEIERCMLGK 316  Trichodesmium erythraeum IMS101
ACA04487      261 DAPEQARRCLAGR 273  uncultured Prochloron sp. 06037A
YP_001521427  284 RPALECRRFLAGR 296  Acaryochloris marina MBIC11017
YP_001007111  267 PALERQIYTLHRL 279  Yersinia enterocolitica subsp. enterocolitica 8081
YP_779698     269 DDAATGSRVLRSR 281  Rhodopseudomonas palustris BisA53
YP_484482     265 ARADECQRAWIGR 277  Rhodopseudomonas palustris HaA2
YP_530600     264 SGPRQSCRLLAER 276  Rhodopseudomonas palustris BisB18
NP_950047     266 LGGSDYPATWTGR 278  Rhodopseudomonas palustris CGA009
ZP_01228789   276 QADGECARVLAGR 288  Aurantimonas sp. SI85-9A1
YP_002314062  272 NEGINCNRILAGR 284  Shewanella piezotolerans WP3

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