Conserved Protein Domain Family
CRD_TK_ROR_related

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cd07469: CRD_TK_ROR_related 
Cysteine-rich domain of proteins similar to tyrosine kinase-like orphan receptors.
The cysteine-rich domain (CRD) is an essential part of the tyrosine kinase-like orphan receptor (Ror) proteins, a conserved family of tyrosine kinases that function in various processes, including neuronal and skeletal development, cell polarity, and cell movement. Ror proteins are receptors of Wnt proteins, which are key players in a number of fundamental cellular processes in embryogenesis and postnatal development. In different cellular contexts, Ror proteins can either activate or repress transcription of Wnt target genes, and can modulate Wnt signaling by sequestering Wnt ligands.
Statistics
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PSSM-Id: 143578
View PSSM: cd07469
Aligned: 10 rows
Threshold Bit Score: 249.245
Threshold Setting Gi: 27923847
Created: 18-Feb-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative Wnt
Feature 1:putative Wnt binding site [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                   # ###        ###                                                     
Q61006       313 SQGYCAQYRGEVCDAVLakDALVFFNTSYRDPEd--AQELLIHTAWNEL-KAVSPLCRPAAEALLCNHLFQECSPGvv-- 387  house mouse
Q07153       315 DLGYCSTYRGEVCQGLLgnGQLVFFNSSFADAEg--TQEMMARSTWTEL-DGVSLLCKPAAESLLCHFIFQDCNPLglg- 390  Pacific electr...
Q9V6K3        66 ENGYCAPYSGKVCKEYL--TGQVWYSLEDPTGGw--KNEQVTTALWDELiSDLTGLCREAAEKMLCAYAFPNCHMEggr- 140  fruit fly
XP_001508938 322 DTGYCSTYKGEVCSAVLvkDALVFFNSSYADSEk--IQEMLAQAVWSEL-KTVSLLCRQAAESLLCNHVFQECHPTavi- 397  platypus
NP_989439    313 DAGYCSTYRGEVCSAILsrNALVFFNSSYADPEe--TQELLVHTAWTEL-KTVSSFCQPAAESLLCNYIFQECKPSgvg- 388  chicken
NP_001004503 309 HAGYCSTYRGDVCRNVLrrDALVFFNYSLPNPEd--AQEYLAQSAWPEL-DGVSSFCRPAARSLLCHSTFQDCNPSglg- 384  zebrafish
XP_001942959  89 PSGYCAQYNGKICRKYLnaSILIWFNNTLTNEGs-eQNEIITTGLWEEMlPSFSKTCRPAAEKLLCLYAFPHCNQDt--- 164  pea aphid
BAE00179     354 GAGYCGRYTGNICRGQLsnPASVWYNISSNDQTggwLNEQLVHGLWEEVvNTLREPCKSAAKKLLCLYAFPECHLDedgf 433  Daphnia magna
XP_002431365  33 SAGYCALYRGEICKDYLvgSGYVWFNKSHDGGW---LNEQITTNLWKEIiVSLKEPCLSAAKKLLCAYAFPQCSLQdnn- 108  human body louse
XP_391863     23 SQGYCAPYNGKICKKYLtgIGKVWFNDSNDNPGg-wLNERITTNLWEELiQRLVEPCRSAAEKMLCMYAFPQCHNSv--- 98   honey bee
Feature 1                                                                                        
Q61006       388 ptPMPICREYCLAVKELFCAKEWQAMEGKahrglyrsgmhllPVPECSKLPSMHRdp----------------taCTRLP 451  house mouse
Q07153       391 ptPKLVCREHCLAVKELYCYKEWITMEDNsrigv---ysaglSLPDCQRLPSIHHdp----------------eaCTRVS 451  Pacific electr...
Q9V6K3       141 avKAPLCFEDCQATHLQFCYNDWVLIEEKkernmfiksrghfRLPNCSSLPHYNAsmr--------------rpnCSYIG 206  fruit fly
XP_001508938 398 ptPKPICREHCLAVRDQYCSNDWLTMEAKshkglyqsglhqlILPECSKLPSMHVdp----------------taCTKIP 461  platypus
NP_989439    389 paPKPICRENCLAVKDLYCFKEWLSMEENsqrgiykpglmllALPECNRLPSLHQdp----------------saCTHIP 452  chicken
NP_001004503 385 paPKPVCREHCLTVKELYCYKEWRSAEERsqrg-----fqhiTLPECTSLPSQQAdp----------------ssCTAVP 443  zebrafish
XP_001942959 165 -sYFPLCYEDCIAVRELFCYKEWALIEANkqrgifykskghfSLPLCENLPHNSQngk---------------pvCSHAM 228  pea aphid
BAE00179     434 arKLPLCYEDCMATRQLFCVDDWAQLESNkqrgfylgsrghfRLPKCEKLPRIGSrsffmssshggskygqdppsCSRGH 513  Daphnia magna
XP_002431365 109 aiGLPLCAEDCTAVKHLFCHNDWALIDYNkrrgiylkskghfTLPNCENLPSFKNakk---------------piCSHAK 173  human body louse
XP_391863     99 --GLPLCYEDCMAVRHQFCFNDWAMIEDNkqrdiyirsrghfTLPDCESLPKIIKgk----------------vtCSHIH 160  honey bee
Feature 1              
Q61006       452 YLDYKK 457  house mouse
Q07153       452 FLDMKK 457  Pacific electric ray
Q9V6K3       207 LTELKE 212  fruit fly
XP_001508938 462 YFEYRK 467  platypus
NP_989439    453 FFDFKK 458  chicken
NP_001004503 444 YVDIKK 449  zebrafish
XP_001942959 229 LTELKQ 234  pea aphid
BAE00179     514 LTQLVP 519  Daphnia magna
XP_002431365 174 LTEMPK 179  human body louse
XP_391863    161 LTDMNE 166  honey bee

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