Conserved Protein Domain Family
CRD_TK_ROR2

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cd07468: CRD_TK_ROR2 
Cysteine-rich domain of tyrosine kinase-like orphan receptor 2.
The cysteine-rich domain (CRD) is an essential part of the tyrosine kinase-like orphan receptor (Ror2), a conserved family of tyrosine kinases that function in various processes, including neuronal and skeletal development, cell polarity, and cell movement. Ror proteins are receptors of Wnt proteins, which are key players in a number of fundamental cellular processes in embryogenesis and postnatal development. In different cellular contexts, Ror proteins can either activate or repress transcription of Wnt target genes, and can modulate Wnt signaling by sequestering Wnt ligands. In addition, a number of Wnt-independent functions have been proposed for both Ror1 and Ror2.
Statistics
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PSSM-Id: 143577
View PSSM: cd07468
Aligned: 3 rows
Threshold Bit Score: 310.408
Threshold Setting Gi: 148225837
Created: 30-Jan-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative Wnt
Feature 1:putative Wnt binding site [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                   # ###      ###                                                       
ABK58595     162 GDGFCQPYRGIACARIIGNRTIYVDSLQMQGEIENRITAAFTMIGTSthLSDQCSQFAIPSFCHFVFPLCDERSRTpkPR 241  chicken
Q01974       170 EDGFCQPYRGIACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGTSthLSDQCSQFAIPSFCHFVFPLCDARSRTpkPR 249  human
NP_001082312 168 KDGFCQPYRGIACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGTSthLSDQCSQFAIPSFCHFVFPLCDDQTSK--PR 245  African clawed...
Feature 1                                                                    
ABK58595     242 ELCRDECEVLENDLCRQEYNIARSNplILMQLQLPKCEDLPrPDTLEAANCIRIGIPVER 301  chicken
Q01974       250 ELCRDECEVLESDLCRQEYTIARSNplILMRLQLPKCEALPmPESPDAANCMRIGIPAER 309  human
NP_001082312 246 ELCRDECEVLENDLCRQEYNIARSNplILMQLHLPNCEELPlPESPEAANCMRIGIPVEK 305  African clawed frog

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