Conserved Protein Domain Family
CRD_TK_ROR1

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cd07467: CRD_TK_ROR1 
Cysteine-rich domain of tyrosine kinase-like orphan receptor 1.
The cysteine-rich domain (CRD) is an essential part of the tyrosine kinase-like orphan receptor 1 (Ror1), a conserved family of tyrosine kinases that function in various processes, including neuronal and skeletal development, cell polarity, and cell movement. Ror proteins are receptors of Wnt proteins, which are key players in a number of fundamental cellular processes in embryogenesis and postnatal development. In different cellular contexts, Ror proteins can either activate or repress transcription of Wnt target genes, and can modulate Wnt signaling by sequestering Wnt ligands. In addition, a number of Wnt-independent functions have been proposed for both Ror1 and Ror2.
Statistics
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PSSM-Id: 143576
View PSSM: cd07467
Aligned: 3 rows
Threshold Bit Score: 317.365
Threshold Setting Gi: 45383149
Created: 27-Jan-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative Wnt
Feature 1:putative Wnt binding site [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                # ###      ###                                                       
Q01973    166 EDGFCQPYRGIACARFiGNRTVYMESLHMQGEIENQITAAFTMIGtssHLSDKCSQFAIPSLCHYAFPYCDEtssVPKPR 245  human
NP_989840 126 EDGFCQPYRGIACARFiGNRTIYMESLHMQGEIENQITAAFTMIGtssHLSDKCSQFAIPSLCHYAFPYCDEtspAPKPR 205  chicken
CAK05398  137 EEGFCQPYRGIACARFiGNRSIFVDSLQMQGEIETQITAAFTMIGtsnHLSDRCSQFAIPSLCHFAFPTCDRssgMDKPR 216  zebrafish
Feature 1                                                                   
Q01973    246 DLCRDECEILENvLCQTEYIFARSNPMILmrlkLPNCEDLPqpespeAANCIRIGIPMADPI 307  human
NP_989840 206 DLCRDECEILENvLCQTEYIFARSNPMILmrlkLPNCEDLXqpdspeAVNCIRIGIXMADPI 267  chicken
CAK05398  217 DLCKDECEILENdLCKTEYIIARSNPLILkrlkLPKCEDLAtldspeAANCMRIGIPIAETI 278  zebrafish

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