Conserved Protein Domain Family
CRD_FZ2

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cd07464: CRD_FZ2 
Cysteine-rich Wnt-binding domain (CRD) of the frizzled 2 (Fz2) receptor.
The cysteine-rich domain (CRD) is an essential extracellular portion of the frizzled 2 (Fz2) receptor, and is required for binding Wnt proteins, which play fundamental roles in many aspects of early development, such as cell and tissue polarity, neural synapse formation, and the regulation of proliferation. Fz proteins serve as Wnt receptors for multiple signal transduction pathways, including both beta-catenin dependent and -independent cellular signaling, as well as the planar cell polarity pathway and Ca(2+) modulating signaling pathway. CRD containing Fzs have been found in diverse species from amoebas to mammals. 10 different frizzled proteins are found in vertebrata. Fz2 is involved in the Wnt/beta-catenin signaling pathway and in the activation of protein kinase C and calcium/calmodulin-dependent protein kinase (CaM kinase).
Statistics
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PSSM-Id: 143573
View PSSM: cd07464
Aligned: 3 rows
Threshold Bit Score: 275.812
Threshold Setting Gi: 17433063
Created: 23-Jan-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative Wnt
Feature 1:putative Wnt binding site [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                # ### ###                                                            
Q08464     40 DHGFCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLEQAIPPCRSIC 119 Norway rat
Q9IA06      2 DHGFCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSLELKFFLCSMYAPVCTVLEQAIPPCRSIC 81  chicken
Q9PUU6     34 EHGFCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSSELRFFLCSMYAPVCTVLEQAIPPCRSIC 113 African clawed frog
Feature 1                                                    
Q08464    120 EraRQGCEALMNKFGFQWPERLRCEHFPRHGAEQICVGQNHSEDGTP 166 Norway rat
Q9IA06     82 EraRQGCEALMNKFGFQWPERLRCENFPRHGAEQICVGQNHSEDGGS 128 chicken
Q9PUU6    114 EraRHGCEALMNKFGFQWPERLRCENFPRHGAEQICVGQNHSEDGGP 160 African clawed frog

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