Conserved Protein Domain Family
CRD_TK_ROR_like

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cd07459: CRD_TK_ROR_like 
Cysteine-rich domain of tyrosine kinase-like orphan receptors
The cysteine-rich domain (CRD) is an essential part of the tyrosine kinase-like orphan receptor (Ror) proteins, a conserved family of tyrosine kinases that function in various processes, including neuronal and skeletal development, cell polarity, and cell movement. Ror proteins are receptors of Wnt proteins, which are key players in a number of fundamental cellular processes in embryogenesis and postnatal development. In different cellular contexts, Ror proteins can either activate or repress transcription of Wnt target genes, and can modulate Wnt signaling by sequestering Wnt ligands. In addition, a number of Wnt-independent functions have been proposed for both Ror1 and Ror2.
Statistics
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PSSM-Id: 143568
View PSSM: cd07459
Aligned: 26 rows
Threshold Bit Score: 116.725
Threshold Setting Gi: 17136878
Created: 24-Apr-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative Wnt
Feature 1:putative Wnt binding site [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                   # ##          ###                                                     
Q01973        168 GFCQPYRG-IACARf---iGNRTVYMESLHMQGei--eNQITAAFTMIGts--shLSDKCSQFAIPSLCHYAFPYCDets 239  human
XP_002123856  183 GRCEQYTG-FACSRf---lQGQYVYLEFFQKQEnv--eQVVSTALQFLAnl--kdVSPSCSTYAPAAFCYYFFSPCKknd 254  Ciona intesti...
NP_001021908  177 GDCVQYRG-EACRQy---lSNKFVMMTNESREEmydidRNLRAAMLFINga--ptISQKCRQLSQAVACHHMYKVCEsds 250  nematode
XP_002130072  185 GKCEKYTG-VACAEf---lNGVDIYVEAFVPQSlm--eSQITTALTQISdt--rhVSEKCQKFAVPAFCYFVFRPCHhna 256  Ciona intesti...
XP_001900033   59 GDCIVYRG-EACREy---lTGRHVMIVXDNREDmydvdRNLRAAMMFINss--pvISAQCKHYSHAVACYHMYKICDrgp 132  agent of lymp...
CAZ34059       10 GFCQEFHS-NVCGKy---lMGHRVYVTREFQQAli--eTQISKFLKLTAtqslhrVREDCLRRLMEAICYYNFPVCLetk 83   Schistosoma m...
XP_002155919  192 SVCRSYTG-SVCSTh---lDPTKMYIYSEDNNEts-leDHLRAPIQKISt----tISKKCQSIALQAICYRIYPQCTdqd 262  green hydra
BAF44473      223 GQCVSYKE-GICASylnqgKTFVAFESNDQSIEsl--nERLKSLIMKLRqk--slISKKCEEYSLAVICYNMFSQCHnat 297  green hydra
Q61006        315 GYCAQYRG-EVCDAvl-akDALVFFNTSYRDPEd----AQELLIHTAWNel--kaVSPLCRPAAEALLCNHLFQECSpgv 386  house mouse
XP_002170314  167 HQCVSKLNsSVCAA-----FFDSKKFFYKDDTTdd-klVMLSKIAEYESfs--sfFSQRCRSHAMAFLCFYNLPYCQnsl 238  green hydra
Feature 1                                                                                         
Q01973        240 sv---------------------pkprDLCRDECEILENvLCQTEYIFARSNpmil------mrlkLPNCEDLPqpesp- 291  human
XP_002123856  255 lgdvi---------------madpqplRLCQEDCDLLKHkTCKNEFFNQNADkfsp------rvfeTSDCSSLPrttp-- 311  Ciona intesti...
NP_001021908  251 n----------------------nqivSICKHDCDVIQNdECPSELALAAQHelvgd----tpkalFPLCSRLSst---- 300  nematode
XP_002130072  257 tgd-------------------lvkgdGLCQEDCNTLKHdICHEEYVQRAQHpfmk------qlfdTAKCSILKssq--- 308  Ciona intesti...
XP_001900033  133 gtdyra-------------tsgmpnilTICRKDCDALQAdLCPKELALAAEHdlvgd----dpkalLPKCQSLNpka--- 192  agent of lymp...
CAZ34059       84 pvsfendvssetqslnensmrylyqtrHLCRQECENVMQnECGPTYDYLDRKilyd------lpemIMDCSRLPiysmd- 156  Schistosoma m...
XP_002155919  263 n----------------------pipiKICENECSKISNgKCVAEFTATNMLsyl--------qriIPNCQEPSdesees 312  green hydra
BAF44473      298 k-----------------------pvpTLCKQDCNSFKKfHCKRELEIIAEEaafi-------slyLPDCDTLPekn--- 344  green hydra
Q61006        387 v----------------------ptpmPICREYCLAVKElFCAKEWQAMEGKahrglyrsgmhllpVPECSKLPsmhr-- 442  house mouse
XP_002170314  239 ds--------------------kpkkmDVCQQDCIKLSTeYCKSEFLQAKDDrflr-------lliPDHCSTLSkd---- 287  green hydra
Feature 1                     
Q01973        292 -eaanCIRIGIP 302  human
XP_002123856  312 -tndhCTTIGLP 322  Ciona intestinalis
NP_001021908  301 ---snCIPVMST 309  nematode
XP_002130072  309 --sseCTSVGLP 318  Ciona intestinalis
XP_001900033  193 ---eyCIPIISV 201  agent of lymphatic filariasis
CAZ34059      157 -npqtCRRIGEP 167  Schistosoma mansoni
XP_002155919  313 setsdCIKLSEE 324  green hydra
BAF44473      345 ---pyCIQAYFT 353  green hydra
Q61006        443 -dptaCTRLPYL 453  house mouse
XP_002170314  288 ----nCIQFRIN 295  green hydra

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