Conserved Protein Domain Family
CRD_FZ1_like

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cd07458: CRD_FZ1_like 
Cysteine-rich Wnt-binding domain (CRD) of receptors similar to frizzled 1.
The cysteine-rich domain (CRD) is an essential extracellular portion of the frizzled 1 (Fz1), frizzled 2 (Fz2), and frizzled 7 (Fz7) receptors, and similar proteins. This domain is required for binding Wnt proteins, which play fundamental roles in many aspects of early development, such as cell and tissue polarity, neural synapse formation, and the regulation of proliferation. Fz proteins serve as Wnt receptors for multiple signal transduction pathways, including both beta-catenin dependent and -independent cellular signaling, as well as the planar cell polarity pathway and Ca(2+) modulating signaling pathway. The CRD domain is well conserved in metazoans - 10 frizzled proteins have been identified in mammals, 4 in Drosophila and 3 in Caenorhabditis elegans. Very little is known about the mechanism by which CRD domains interact with their ligands. The domain contains 10 conserved cysteines.
Statistics
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PSSM-Id: 143567
View PSSM: cd07458
Aligned: 15 rows
Threshold Bit Score: 226.909
Threshold Setting Gi: 118343942
Created: 24-Apr-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative Wnt
Feature 1:putative Wnt binding site [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                 # ### ###                                                              
Q9I9M5        49 GYCQPISIPLCTDIaYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELKFFLCSIYAPVCTVLEqALPPCRSLCDr 128  African clawed...
XP_001901058  38 DKCVPITMQMCRDIpYNMTLFPNILGHTKEEDASLEIHQFLPLVKVKCSEDLKFFLCTIYAPVCTVLErPIPPCRHLCLs 117  Brugia malayi
NP_001124086  31 GFCQPISIPLCTDIaYNETIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPDLKFFLCSMYAPVCTVLEqALPPCRSLCEr 110  zebrafish
XP_002433979  55 GRCEPISIPLCKDIqYNETIMPNLLNHQKQEDAGMEVHQFFPLVKVKCSPDLQFFLCSMYAPVCTILEyPIPPCRSLCMs 134  black-legged tick
XP_002233939  43 GRCEAITIPLCTDIqYNETIMPNLLNHQKQEDAGLEVHQFFPLVKVQCSPDLKFFLCAMYAPVCTVLEeAIPPCRSLCNs 122  Florida lancelet
XP_781961     42 GRCEAITIPLCEDMpYNMTIMPNLLNHQHQEDAGLEVHQFYPLVKVQCSEDLKNFLCSMYAPVCTVLDsALPPCKSLCLs 121  purple urchin
XP_001647540  27 KRCEPVTIPLCTGLqYNMTIFPNTLKHRTQEEAALEVHQFFPLVKVDCSKDLAFFLCSVYAPVCTVLEtPLPPCRSLCLt 106  starlet sea an...
O16147        35 RKCEHITIPMCKNLdYNQTVFPNLLGHTTQSEAGPAIAQFNPLIKVKCSEDIRLFLCTVYAPVCTVLEkPIQPCRELCLs 114  Caenorhabditis...
XP_974249     32 DKCKPITVPFCIDVpYNSTIFPNLVGHNTQEDAGYEVHQYFPLIKINCSADLHLFLCSVFVPVCTILEkPVPPCRSLCLs 111  red flour beetle
XP_002202934 528 SSCEPLTVPLCQNMmYNETVFPNILGHTKQDEASLEVHQYYPLVKMGCSDVLEEFLCFVYTPPCTILEsPIPPCRSLCEs 607  Florida lancelet
Feature 1                                                             
Q9I9M5       129 aRQGCEALMNKFGFqWPESLRCEKFPIng--------------agELCVGQNT 167  African clawed frog
XP_001901058 118 aKNGCENLMNKFGFkWPPLLACERFPVd-----------------GMCVGENK 153  Brugia malayi
NP_001124086 111 aRQGCEALMNKFGFqWPESLACESFPVhg---------------gELCVGQNT 148  zebrafish
XP_002433979 135 aRSGCESLMNKFGFkWPESLECDKFPEvg--------------seKLCVGENV 173  black-legged tick
XP_002233939 123 aRTGCEALMNKFGFqWPESLECSKFPVqgt-------------pgKICVGENR 162  Florida lancelet
XP_781961    122 aRNGCESLMNKFGFsWPASLSCDQFPEg-----------------GLCFDRNR 157  purple urchin
XP_001647540 107 vRSGCEGLMKRFGFtWPDSLSCERFPKlg---------------dEICVGENT 144  starlet sea anemone
O16147       115 aKNGCESLMKKFGFqWPDQLDCNKFPVt-----------------DLCVGKNS 150  Caenorhabditis elegans
XP_974249    112 aKSGCEGIMRKFGYnWPENLDCNQYPEn----------------sNLCVEKHN 148  red flour beetle
XP_002202934 608 aRGSCEGLMMKFGFpWPENLDCSKFPEenqgppwenepgslgldrSLCLKAPE 660  Florida lancelet

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