Conserved Protein Domain Family
CRD_FZ9_like

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cd07457: CRD_FZ9_like 
Cysteine-rich Wnt-binding domain (CRD) of receptors similar to frizzled 9.
The cysteine-rich domain (CRD) is an essential extracellular portion of the frizzled 9 (Fz9) and frizzled 10 (Fz10) receptors, and similar proteins. This domain is required for binding Wnt proteins, which play fundamental roles in many aspects of early development, such as cell and tissue polarity, neural synapse formation, and the regulation of proliferation. Fz proteins serve as Wnt receptors for multiple signal transduction pathways, including both beta-catenin dependent and -independent cellular signaling, as well as the planar cell polarity pathway and Ca(2+) modulating signaling pathway. The CRD domain is well conserved in metazoans - 10 frizzled proteins have been identified in mammals, 4 in Drosophila and 3 in Caenorhabditis elegans. Very little is known about the mechanism by which CRD domains interact with their ligands. The domain contains 10 conserved cysteines.
Statistics
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PSSM-Id: 143566
View PSSM: cd07457
Aligned: 5 rows
Threshold Bit Score: 234.31
Threshold Setting Gi: 17432964
Created: 24-Apr-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative Wnt
Feature 1:putative Wnt binding site [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                 # ### ###                                                              
XP_002219615  27 GSCERITIPMCIGIGYNMTRMPNrlghtsqteAAIKVHEWssLVQYDCSVNLRFFLCSLYAPMCTeqvpdipiPACRPMC 106 Florida lancelet
O00144        37 APCQAVEIPMCRGIGYNLTRMPNllghtsqgeAAAELAEFapLVQYGCHSHLRFFLCSLYAPMCTdqvs-tpiPACRPMC 115 human
Q9ULW2        32 GKCQPIEIPMCKDIGYNMTRMPNlmghenqreAAIQLHEFapLVEYGCHGHLRFFLCSLYAPMCTeqvs-tpiPACRVMC 110 human
XP_001630630  30 SKCTPITIPLCMGIGYNATRFPNflaqesqeeAAKRIHEFkpLIAVNCAPLLRFFLCSVFVPMCTkevn-vpiYACRSMC 108 starlet sea ane...
XP_790565     32 GHCERITIDFCQGIGYNMTKMPNlfghvtqseAAPSIHEFhpLVVVGCAEHLRLFLCSMYAPMCSehid-iriPSCQSMC 110 purple urchin
Feature 1                                                        
XP_002219615 107 EEVRDACSPIMEQFsfswpENLNCDTLPeend------renLCMLAPN 148 Florida lancelet
O00144       116 EQARLRCAPIMEQFnfgwpDSLDCARLPtrnd------phaLCMEAPE 157 human
Q9ULW2       111 EQARLKCSPIMEQFnfkwpDSLDCRKLPnknd------pnyLCMEAPN 152 human
XP_001630630 109 ESARDGCSPMMQRFgfnwpDTLDCDRLPkkgdpqaksdptkLCMAAPN 156 starlet sea anemone
XP_790565    111 DDVRRKCEPVMARFsfswpESMNCDKLPrg---------kdLCMVAPD 149 purple urchin

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