Conserved Protein Domain Family
CRD_Collagen_XVIII
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cd07455: CRD_Collagen_XVIII 
Cysteine-rich domain of the variant 3 of collagen XVIII (V3C18 ).
The cysteine-rich domain (CRD) is an essential part of the variant 3 of collagen XVIII (V3C18), which regulates major cellular functions such as the differential epithelial morphogenesis of early lung and kidney development. V3C18 is a 170 kD protein, which is proteolotically processed into the CRD-containing 50 kD glucoprotein precursor that binds Wnt3a through its CRD domain and suppresses the Wnt3a-induced stabilization of beta catenin. Full-length V3C18 is unable to inhibit Wnt signaling.
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Statistics
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PSSM-Id: 143564
Aligned: 5 rows
Threshold Bit Score: 181.938
Created: 9-Feb-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative Wnt
Feature 1:putative Wnt binding site [polypeptide binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                   # ### ###                                                          
Q60569     366 STSRCLPLPPtLTLCSRLGIGHFWLPNHLHHTDSVEVEATVQAWGRFLHTNCHPFLAWFFCLLLAPSCGPGppp-plPPC 444  Cook's mouse
P39060     330 PAGRCLPLPPsLPVCGHLGISRFWLPNHLHHESGEQVRAGARAWGGLLQTHCHPFLAWFFCLLLVPPCGSVppp-apPPC 408  human
AAL14259   492 PNARCFPTPTsLSFCKRLGIDSFLLPNFLNHSTVLEIQAALHDWEGLFKSQCHQYLEWFFCLLLAPSCNTGtlapppVPC 571  African clawed frog
CAQ13793   203 EPLRCLPVDSgLPFCTRRGVESFSVPNFLNQSSVEEVRMVLTEWAWLLRSGCHHSLEWFFCLLLTPRCGHSgs---lLPC 279  zebrafish
CAG10302   101 PRPPCLPVPSdWPICSSKHPRSLTLPNLLNHTSVDEVGAVLAEWAWLVEKGCHPSAEWFLCLLLVPGCPGRa----pPPC 176  spotted green pu...

Feature 1                                                                   
Q60569     445 RQFCEALEDECWNYLAGDrLPVVCASLPsqe-----------------dgyCVFIGPAAEN 488  Cook's mouse
P39060     409 CQFCEALQDACWSRLGGGrLPVACASLPtqe-----------------dgyCVLIGPAAER 452  human
AAL14259   572 RQFCEVLQDACWNLLEGShLPVSCDSLPenns----------------gvsCVYIHFYAGS 616  African clawed frog
CAQ13793   280 RSSCEVLQDSCWTLLDEGrLPVECKSLPeekhdgyrclsvsnlkeesgvslLQLIGDPPPN 340  zebrafish
CAG10302   177 RSFCQTLRDSCWASLEKGrFPVACHRLPeg--------------------rPSAAGPPAWP 217  spotted green pufferfish

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