Conserved Protein Domain Family
CRD_crescent

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cd07453: CRD_crescent 
Cysteine-rich domain of the crescent protein.
The cysteine-rich domain (CRD) is an essential part of the crescent protein, a member of the secreted frizzled-related protein (SFRP) family, which regulates convergent extension movements (CEMs) during gastrulation and neurulation. Xenopus laevis crescent efficiently forms inhibitory complexes with Wnt5a and Wnt11, but this effect is cancelled in the presence of another member of the SFRP family, Frzb1. A potential role for Crescent in head formation is to regulate a non-canonical Wnt pathway positively in the adjacent posterior mesoderm, and negatively in the overlying anterior neuroectoderm.
Statistics
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PSSM-Id: 143562
View PSSM: cd07453
Aligned: 3 rows
Threshold Bit Score: 252.169
Threshold Setting Gi: 38198627
Created: 12-Feb-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative Wnt
Feature 1:putative Wnt binding site [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                # ### ###                                                            
AAF70300   36 SRCMRIPKsmALCYDIGYSEMRIPNLLEHETMAEAIQQSSSWLPLLARECHPDARIFLCSLFAPICF--DRYIFPCRSLC 113 African clawed frog
O42397     42 SSCTAIPRsmALCYDIGYSEMRIPNLLEHETMPEVIQQSSSWLPLLARECHPDARIFLCSLFAPICL--DRLIYPCRSLC 119 chicken
NP_938176  26 APCMRIPKsmALCYDIGYCEMRIPNHLEHEQMAEVLQQEWRWVPLLNKECSPDARIFLCCLFAPICWplDSPIYPCRSVC 105 zebrafish
Feature 1                                                              
AAF70300  114 EAVRSSCAPIMACYGYPWPEILKCDKFPEDHGmCISTITNDTGSTRRTVPRASCRDC 170 African clawed frog
O42397    120 EAVKRSCAPVMACYGYPWPEILNCNKFPADHElCIAAVSTDESSSSRRMPRASCKDC 176 chicken
NP_938176 106 EAVRSGCAPLMKAYGFTWPESLHCDKFPVDNDlCISPQFINTLEPEDVKVCPPCEME 162 zebrafish

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