Conserved Protein Domain Family
CRD_FZ6

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cd07450: CRD_FZ6 
Cysteine-rich Wnt-binding domain (CRD) of the frizzled 6 (Fz6) receptor.
The cysteine-rich domain (CRD) is an essential extracellular portion of the frizzled 6 (Fz6) receptor, and is required for binding Wnt proteins, which play fundamental roles in many aspects of early development, such as cell and tissue polarity, neural synapse formation, and the regulation of proliferation. Fz proteins serve as Wnt receptors for multiple signal transduction pathways, including both beta-catenin dependent and -independent cellular signaling, as well as the planar cell polarity pathway and Ca(2+) modulating signaling pathway. CRD containing Fzs have been found in diverse species from amoebas to mammals. 10 different frizzled proteins are found in vertebrata. Frizzled 6 (Fz6) is expressed in the skin and hair follicles and controls hair patterning in mammals using a Fz-dependent tissue polarity system, which is similar to the one that patterns the Drosophila cuticle.
Statistics
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PSSM-Id: 143559
View PSSM: cd07450
Aligned: 7 rows
Threshold Bit Score: 231.193
Threshold Setting Gi: 41056221
Created: 23-Jan-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative Wnt
Feature 1:putative Wnt binding site [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                # ### ###                                                            
Q5RCN4     21 SLFTCEPITVPRCMKMAYNMTFFPNLMGHYDQSIAAVEMEHFLplANLECSPNIETFLCKAFVPTCTEQIHVv------P 94  Sumatran orangutan
O60353     20 SLFTCEPITVPRCMKMAYNMTFFPNLMGHYDQSIAAVEMEHFLplANLECSPNIETFLCKAFVPTCIEQIHVv------P 93  human
Q61089     20 SLFTCEPITVPRCMKMTYNMTFFPNLMGHYDQGIAAVEMGHFLhlANLECSPNIEMFLCQAFIPTCTEQIHVv------L 93  house mouse
AAH84094   23 SLFTCEPITVPRCTGMNYNMTFFPNLMEHYDQDIAALRMEPFLplLNLHCSPEVHMFLCRAFVPECTEPKHIt------M 96  African clawed frog
XP_418372  21 SLFTCEPITISRCSRMPYNMTFFPNIMGHYDQDTAALQMEPFLtlMNLHCSPDVHTFLCKAFVPACLEQVHVi------H 94  chicken
CAF98078   23 SLFTCEPIKVHWCLGMPYNMTYFPNMMDHFDQDIAATNMKPFMplIKLRCSPGVHHFLCQAFFPACFENVGS-------R 95  spotted green puff...
NP_956855  20 TLFTCEPVQVQWCLDMPYNTTFFPNMLEHYDQDIAAVRMKEFMplVSVRCSPDAHLFLCQAFVPECRTHSHSqththvlR 99  zebrafish
Feature 1                                                                  
Q5RCN4     95 PCRKLCEKVYSDCKKLIDTFGIRWPEELECDRLQYCDETVPv--------TFDPHTEFLGP 147 Sumatran orangutan
O60353     94 PCRKLCEKVYSDCKKLIDTFGIRWPEELECDRLQYCDETVPv--------TFDPHTEFLGP 146 human
Q61089     94 PCRKLCEKIVSDCKKLMDTFGIRWPEELECNRLPHCDDTVPv--------TSHPHTELSGP 146 house mouse
AAH84094   97 PCRSLCERVHSDCKNLIETFGITWPAELECDRMRDCNYSQSkvggpngpqDARQHPEKVSK 157 African clawed frog
XP_418372  95 PCRNLCEKVYSDCKQLIDTFGITWPEELECSRLVNCDETAPata----pvTTNAHGTQKTP 151 chicken
CAF98078   96 PCREECKTVLSDCKDNIQVFGISWPPELQCDKLDPCFLTRDd--------TTPETPPATSP 148 spotted green pufferfish
NP_956855 100 PCRERCERVRSDCRAVMHTFDISWPSELQCERLESCGGSAVdv------tTAGRSGAGSSP 154 zebrafish

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