Conserved Protein Domain Family
Cby_like

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cd07429: Cby_like 
Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins
Chibby(Cby) is a well-conserved nuclear protein that functions as part of the Wnt/beta-catenin signaling pathway. Specifically, Cby binds directly to beta-catenin by interacting with its central region, which harbors armadillo repeats. Cby-beta-catenin interactions may also involve 14-3-3 proteins. By competing with other binding partners of beta-catenin, the Tcf/Lef transcription factors, Cby inhibits transcriptional activation. Cby has been shown to play a role in adipocyte differentiation. The C-terminal region of Cby appears to contain an alpha-helical coiled-coil motif.
Statistics
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PSSM-Id: 143631
View PSSM: cd07429
Aligned: 19 rows
Threshold Bit Score: 104.343
Threshold Setting Gi: 157135889
Created: 30-Sep-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
NP_056188            1 MPFFGNTFSPKKTPPRKsasl----snlHSLDRSTREVELGLEYGSPTMNLAGQSLKFENGQWIAETGvs---------- 66  human
XP_001123003         1 MPLFSNKFSPKKTPTRKvgvf----lanKNFSPKRIEKELGPNIGPIRLKLGDQETVFESGSWIPESGki---------- 66  honey bee
XP_001812890         1 MPLFGSKFAPKQPPLRK-----------FANNVSEDLDELVSGQRSVQVRLGSQELVFENGDWIPESGes---------- 59  red flour...
NP_001157916        81 ADHISRPFSPRRPPLRRmpsl----stfYLLDHNTRQAELGLAYGAPCMRLSNQAFVFRGGRWTTESQlartrs-----p 151 human
XP_001505906        29 DHFSRRRFSPRRPPLRRisfm----stfYLLDHRTRQAELGLSYGPPRTRLSRQTLIFLEGRWVNDGEaahsp------- 97  platypus
FlyBase:CG13415-PB   1 MPLFNKKFESKPIPVRQg----------RCNIGHPVATEDLDDFRQISLTLGNKELRFADGIWMHSTRk----------- 59  fruit fly
XP_001663606         1 MPIFTKKFAPKVAPPRTa----------RLNIGCPPQQEDLDEFRNIRLNLLDKQLCFVDGVWMSAAApgggssgmtaal 70  yellow fe...
XP_002109251         1 MPLFSRNGLGGLISQKKprqg----qqnVATPQPNNLDPVSLENGAIKVKLGHNVLCYEDGLWTSEVGgs---------- 66  Trichopla...
XP_001640499         1 MPLFGKKKSPRRKLEAGssnl----sksNVSLADTSVDPNDPNAALVKLKLGGNELVFRDGEWCSDATg----------- 65  starlet s...
XP_002158679         1 MPLFGKPSFKASRKVPKrradagssntiQLADKDTLDPNLDFSQIPLQLSLGGRKMMFQNGSWISRDAgse--------- 71  green hydra
NP_056188           67 --ggVDRREVQRLRr-RNQQLEEENNLLRLKVDILLDMLSESTAE 108 human
XP_001123003        67 ---gGTYKENEKLKk-EIKRLEDENNLLKLKFEVLLDMLTQTTAE 107 honey bee
XP_001812890        60 ---gTAHKSNQRLRk-KIQELQEENNMLRLKYAVMLNMLTQTTAE 100 red flour beetle
NP_001157916       152 llsrTAWGWKAQVQrsKSQVLLEENNYLKLQQELLIDMLTETMAR 196 human
XP_001505906        98 plapAGGRSPARLA--KVQSLLEENNYLKLQQELLMDMLTEATAR 140 platypus
FlyBase:CG13415-PB  60 ----GDVDDMLRLNk-KFRALEEENNMCNLKIEVMLDLLAERDGT 99  fruit fly
XP_001663606        71 psnaSTIDDLLRMKr-RLKTLEQENNLYQVKLDVLLDLLTENITS 114 yellow fever mosquito
XP_002109251        67 --sgNTLKEITRIKk-HNIQLAEENNLLKYKINVLLDMLAVSNAD 108 Trichoplax adhaerens
XP_001640499        66 ---aVKGSADANLQk-INNQLKEENNYLKYKIDVLLDMLAATTAD 106 starlet sea anemone
XP_002158679        72 -sslQESDEATALKe-KILILEEERNLLKYKIELLLDMLAVSQSD 114 green hydra
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