Conserved Protein Domain Family
MPP_PP7

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cd07418: MPP_PP7 
PP7, metallophosphatase domain
PP7 is a plant phosphoprotein phosphatase that is highly expressed in a subset of stomata and thought to play an important role in sensory signaling. PP7 acts as a positive regulator of signaling downstream of cryptochrome blue light photoreceptors. PP7 also controls amplification of phytochrome signaling, and interacts with nucleotidediphosphate kinase 2 (NDPK2), a positive regulator of phytochrome signalling. In addition, PP7 interacts with heat shock transcription factor HSF and up-regulates protective heat shock proteins. PP7 may also play a role in salicylic acid-dependent defense signaling. The PPP (phosphoprotein phosphatase) family, to which PP7 belongs, is one of two known protein phosphatase families specific for serine and threonine. The PPP family also includes: PP2A, PP2B (calcineurin), PP4, PP5, PP6, Bsu1, RdgC, PrpE, PrpA/PrpB, and ApA4 hydrolase. The PPP catalytic domain is defined by three conserved motifs (-GDXHG-, -GDXVDRG- and -GNHE-). The PPP enzyme family is ancient with members found in all eukaryotes, and in most bacterial and archeal genomes. Dephosphorylation of phosphoserines and phosphothreonines on target proteins plays a central role in the regulation of many cellular processes. PPPs belong to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.
Statistics
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PSSM-Id: 163661
View PSSM: cd07418
Aligned: 6 rows
Threshold Bit Score: 649.169
Threshold Setting Gi: 116059065
Created: 24-Apr-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
active sitemetal binding
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                  # #    
NP_851258      11 WPDGGALTNDWVHGLMSCFEWsswnlpPSQLPSLLPVNVFDSLVLTAHKILHKErnCVHIDdldsvsnVVVVGDIHGQLH 90   thale cress
ABK24367       40 WPPQGSLSTEWVESLAAVFDWssryvaPSELPSVLPVSVFDSLAMSASKILHREpnCLEIDvds-ncsVVVVGDVHGQLH 118  Sitka spruce
XP_001768103   38 WPENGALTLEWVQQLGKVLEFasrhllPTELPTVLPVPVIDSLLLAAHKLLHREpnCVDVPvdh-scsVVLVGDVHGQFH 116  Physcomitrell...
Q9LNG5        589 WPSGGKLTFSWVCEVMLVFDWssknlpPCEFSSVLPFNVLDELVLFASKILKKEpnCVRIDsek--aeVVVVGDLHGQLH 666  thale cress
CAL54772        7 MEVRLPITPEWIDELTTRMEEnthggkPRMLSRIVDAREAERLMTCATRVLKREktLTRLTmeegveeCIVVGDTHGQYH 86   Ostreococcus ...
CAA03886       11 WPDGGALTNDWVHGLMSCFEWsswnlpPSQLPSLLPVNVFDSLVLTAHKILHKErnCVHIDdldsvsnVVVVGDIHGQLH 90   thale cress
Feature 1                               #   #                           ##                        
NP_851258      91 DLLFLLKDTGFPcqnRCYVFNGDYVDRGAWGLETFLVLLSWKVLMPDRVYLLRGNHESKYCTSMYGFEKEVLTKYGdk-g 169  thale cress
ABK24367      119 DVLNVLQTAGPPspnRFFVFNGDYVDRGAWGLETFLLLLAWKVLLPHRVFLLRGNHESKFCTAVYGFEQEVMAKYGdq-g 197  Sitka spruce
XP_001768103  117 DVLHLLEIAGPPsanRLFVFNGDYVDRGAWGFETYFYLLSWKLLLPHRVFLLRGNHETKFCTSAYGFEQEIMSKFGdr-a 195  Physcomitrell...
Q9LNG5        667 DLLYLMQDAGFPdgdRFYVFNGNYVDIGAWGLETFLLLLSWKVLLPARVYLLRGSHESESCTSMYGFKNEVLTKYGdk-g 745  thale cress
CAL54772       87 DVLKLFEIAGKPdetRTYVFNGDFVDRGAWGVELFFTLIAHKVSSPDRVILLRGNHETEFCTECYGFERELKVKYGntmg 166  Ostreococcus ...
CAA03886       91 DLLFLLKDTGFPcqnRCYVFNGDYVDRGAWGLETFLVLLSWKVLMPDRVYLLRGNHESKYCTSMYGFEKEVLTKYGdk-g 169  thale cress
Feature 1                                    #                                                    
NP_851258     170 kHVYRKCLGCFEGLPLASIIsgrVYTAHGGLFRspvlpkrttrgkkn-----------rrvvllepepssmkLGTLDELM 238  thale cress
ABK24367      198 kHIYRKCLGCFEGLPLASIIagcVYTAHGGLFRntesplskrskgkk-----------grrlvscsdskvlrLGSLGELA 266  Sitka spruce
XP_001768103  196 kHLYRKLLGCFEGHPLAARVagcVYMAHGGLFRqvekevpkkqkgkss---------rqsntsrivneknlkIGTIDDLQ 266  Physcomitrell...
Q9LNG5        746 aAVYKKCLECFQLLPLASVIagkVYTAHGGLFRdvssflsdkqernrkrkrtqkkqtdntvldtedrseslpLGSLKDLS 825  thale cress
CAL54772      167 rKLYPLFLEVCSHMPLACLLnerTLVLHGGLFRspslskr-------------------------earenpkLGTLHDLE 221  Ostreococcus ...
CAA03886      170 kHVYRKCLGCFEGLPLASIIsgrVYTAHGGLFRspvlpkrttrgkkn-----------rrvvllepepssmkLGTLDELM 238  thale cress
Feature 1                               #                                         #               
NP_851258     239 QARrsvlDPPWEGSNLIPGDVLWSDPsmtpGLSPNeqRGIGLLWGPDCTEDFLKKYELKLIIRSHEGPDAREKRtglggm 318  thale cress
ABK24367      267 KARrivlDPPWEGLNLIPGDVLWSDPsthpGLSPNkeRGIGLLWGPDCTEEFLNKNHLKLIIRSHEGPDAREKRpglagm 346  Sitka spruce
XP_001768103  267 KVRrtvlDPSGFGANVIPGDVLWSDPspknGLSHNdqRGIGLLFGPDCTQEFMEKHKLKLIVRSHEGPDAREKRpdmeam 346  Physcomitrell...
Q9LNG5        826 KVKrrviDPPTEGSNLIPGDILWSDPskdtGLFLNkeRGIGLLWGPDCTAKFLQDNNLKWIIRGKGAPDERAKRddlapm 905  thale cress
CAL54772      222 KASkggaDPMGEGRSMIAGDVLWSDPiledGLRQNvnRGIGIQFGPAQTREFMERENLKLIIRSHEGPDARHDRpempsi 301  Ostreococcus ...
CAA03886      239 QARrsvlDPPWEGSNLIPGDVLWSDPsitpGLSPNeqRGIGLLWGPDCTEDFLKKYELKLIIRSHEGPDAREKRtglggm 318  thale cress
Feature 1                                                                                 
NP_851258     319 dnGYTIDHnve-sgkLITIFSAPDYPQFqa-tEERYKNKGAYIILqapdfsDPQFHSFEAVKPRPKAHPYYD 388  thale cress
ABK24367      347 hkGYTIDHdvq-sgkLITLFSAPDYPQFqa-sKERYNNRGAYIILeppdfaNPNFHTFEAVMPRPKVNAYYD 416  Sitka spruce
XP_001768103  347 nkGYTVDHvvn-agkLITLFSAPDYPQFqa-sEDRYYNKGAYIVLeppdfsDPHFFQFEAVKPRPKVNPYYD 416  Physcomitrella patens...
Q9LNG5        906 ngGYAEDHe-----gLITLFSAPDHPQFqd-tEERHNNKAAYIILqipeceELKFQPLEAVSPRPKAEAYYD 971  thale cress
CAL54772      302 meGFCVDHdcgevgkLCTLFSAPNYPQFidvdDERHNNRAAFVTLrpetswCAPEPTSFDFVPRPPSQCYYD 373  Ostreococcus tauri
CAA03886      319 dnGYTIDHnve-sgkLITIFSAPDYPQFqa-tEERYKNKGAYIILqapdfsDPQFHSFEAVKPRPKAHPYYD 388  thale cress

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