1T71,1T70,2CV9,4B2O,2Z06


Conserved Protein Domain Family
MPP_DR1281
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cd07382: MPP_DR1281 
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Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain
DR1281 is an uncharacterized Deinococcus radiodurans protein with a domain that belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.
Links
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Statistics
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PSSM-Id: 277328
Aligned: 22 rows
Threshold Bit Score: 349.963
Created: 26-Oct-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:4B2O: Bacillus subtilis YmdB phosphodiesterase binds 2 Fe2+ and PO4-
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           #                              ##                          ##  #          
1T71_A      6 KFIFLGDVYGKAGRNIIKNNLAQLKSkyqADLVIVNAENTThGKGLSLKHYEFLKEAGVNYITMGNHTWFQKlDLAVVIN 85  Mycoplasma pneumoniae
4B2O_A      2 RILFIGDVVGSPGRDMVKEYVPKLKTkykPHFTIINGENAAhGKGLTEKIYHSLIQSGADAITMGNHTWDKK-EIFDFID 80  Bacillus subtilis ...
CAK98417    2 NIVMIGDIYAQAGRIAINKYLPQIIKkykIDLIIANGENTThGKSLSKHHYNELKELGINIITSGNHIFRNP-EVLNYIE 80  Spiroplasma citri
NP_758277   3 KILFIGDISGEMGKIAVESELPKLKKelnIDYVIANAENTTkGRGLNWTDYRKLSSCGIDFFTMGNHTWHKR-DIYDILK 81  Mycoplasma penetra...
NP_975477   3 KVLMIGDVYAKPGREMLEKHLKNIVDqnqIDFIVVNGENTThGKSICKKHYDFYKSLNVDVITSGNHIFKNA-EVLEYIK 81  Mycoplasma mycoide...
NP_661261   7 NILFIGDVVGNPGLQIVSRMLKGFISkygVDFVICNGENAHnGKGMSLEALNLMLEAGVDVVTGGNHTWNNF-NFFETLK 85  Chlorobium tepidum...
EDZ38552   17 RLLCVGDVFGRPGRNALEKGIARLRDqapLDAIIVNGENLAgGKGLNQKTANECFQMGVTSITTGNHLFDQK-DVLDLLR 95  Leptospirillum sp....
CAJ71096    4 NVLILGDIVGSPGRTIIKNKLKSFMEkeeIHFCIANGENAAaGAGITDQITKELFSYGVDVITMGDHVWDKK-EKVHVLE 82  Candidatus Kueneni...
NP_212639   7 KTLIIGDIIGESGLKKVFFNLKNIKNkyrIDLVIANGENSSnGFGITPEIANNLFRSGVNVITTGNHVYSNC-KINDYLN 85  Borrelia burgdorfe...
ACN23812    4 HILSVGDVVGEPGLSHLEKTLRPLKKlkdIAFTVVNGENAA-SIGLTPQQAERIYDAGADVITLGNHTFGKM-QIADFLD 81  Clostridium sp. en...

Feature 1                                                                                     
1T71_A     86 KK-DLVRPLNLDtsfafhnLGQGSLVFEfn--kaKIRITNLLGTSVPlpfKTTNPFKVLKELILkrd-----cdLHIVDF 157 Mycoplasma pneumoniae
4B2O_A     81 DVpNLVRPANFPeg----tPGKGITYVKan--gkELAVINLQGRTFLp--PLDDPFLKADELIAeaak---rtpYIFIDF 149 Bacillus subtilis ...
CAK98417   81 EVnDLLKPANMNsf----tPGKGTVVVKin--nkKIRVTNLMGRSFMd--PVDNPYTIFEEIINndn-----sdLHFVDF 147 Spiroplasma citri
NP_758277  82 TKnNIIRPANLKsvfeeskVGFGTKVVTik--nkTFRITNLLGISVSirdMQTNPFIELQNIIDnsk----rtdFHIVDF 155 Mycoplasma penetra...
NP_975477  82 TTnDLLKPLNMSkh----tPGNGYVIVKkn--kkKIAVVSLMGQSFMd--TVNNPYDALDEFLKtnt----dfdILLVDF 149 Mycoplasma mycoide...
NP_661261  86 THeRVLRPQNYPkg----tYGKGYGVYKlprglgNITVLNLQGRTFMs--PIDCPFRTADWVIKqtke---qssLLVVDF 156 Chlorobium tepidum...
EDZ38552   96 KEnRVLRPLNYSae----cPGTGACIYVlpg-gqTLGVINLIGRVFMs--PSDCPFHAADRILEfwdrsdtrpdITVVDF 168 Leptospirillum sp....
CAJ71096   83 IHkNIIRPLNYSpy----aIGKGFVVATskl-gyPIGVVNLLGRVFMk--PIDCPFRGVEKILGvlsn---etsMIFVDM 152 Candidatus Kueneni...
NP_212639  86 KQtYILRPNNFSdl----lDGHGYCFLTir--deKVAVVNVQGVLNMn-fIVKNPFDNTKKLVNmlsn---kakTIFVDF 155 Borrelia burgdorfe...
ACN23812   82 DApYILRPANYTgr----aPGRGCGIYNln--giRIRVVNLIGRCDLs-wGSDNPFTVADKLLDger-----tdFTLVDF 149 Clostridium sp. en...

Feature 1     #                        # #                                                    
1T71_A    158 HAETTSEKNAFCMAFDGYVTTIFGTHTHVPSADLRITpKGSAYITDVGMCGpgfgSVIGANPEQSIRLFCAgsrEHFEV- 236 Mycoplasma pneumoniae
4B2O_A    150 HAEATSEKLALGWYTDGRASAVVGTHTHVQTADNRILpKGTAYITDVGMTGpy-dGILGMDRETIIKRFKTnlpVRFTV- 227 Bacillus subtilis ...
CAK98417  148 HAEASAEKLAFAWNYDGIITGFFGTHTHVQTADNRILpKGTAYITDVGMCGsy-nSIIGANPEEIIIKEKTglpVRFEPa 226 Spiroplasma citri
NP_758277 156 HCETTSEKNAFFINFQGAVSAILGTHTHVQTNDAKII-NNTAYITDVGMTGas-nGVIGAKPDSIIYMFKGy-sDRFKLe 232 Mycoplasma penetra...
NP_975477 150 HAESTAEKIAFAFNYDGIITAFVGTHTHVMTADERLLpNKTAFISDIGMTGvi-dSIIGVEVNDVIKRAKTglpVKFNI- 227 Mycoplasma mycoide...
NP_661261 157 HAEATAEKISLAWYLDGRASAVIGTHTHVQTADERIFpKGTAYLTDVGMTGpy-qSVIGMQVKSAVDRMLYqtpHKYEC- 234 Chlorobium tepidum...
EDZ38552  169 HGEASGEKRAMGFHLDGRVHVLFGTHTHVQTNDLEILpAGTLYLTDVGLTGpr-wSVIGVAPEAALKKYRThvpAPFEV- 246 Leptospirillum sp....
CAJ71096  153 HAEATSEKIAMGLFLDGRVSAVVGTHTHVMTADEKILpKGTAYITDIGMTGph-eSILGRKSDCVLKAIMTqmpTRFEV- 230 Candidatus Kueneni...
NP_212639 156 HAESNYEKESFGYFLNGFVTGVVGTHTHVMTQDERILsKGTAYISDIGMTGgl-nSVIGFNPDISLKGLLEytpLRAEV- 233 Borrelia burgdorfe...
ACN23812  150 HAQATSEKLAMGYYLDGRVSALWGTHTHVPTADERVYpKGTGYITDLGMTGav-eSVLGVKPEQSVESFLGglpGRFQN- 227 Clostridium sp. en...

Feature 1                                    
1T71_A    237 -SKCGAQLNGVFFEVDvn-tKKVIKTEAIRI 265 Mycoplasma pneumoniae
4B2O_A    228 -AEGKTTLSGVVIDIDdq-tKKAVKIERILI 256 Bacillus subtilis subsp. subtilis str. 168
CAK98417  227 tENDKLIFSAVWLQVDdk-tNQAVKIERILI 256 Spiroplasma citri
NP_758277 233 eQIGPYQFCGVILSFNeh-tNKVVQIKKVYL 262 Mycoplasma penetrans HF-2
NP_975477 228 -ATGKCWLNAVIIEIDdk-tNKATSIKRLTI 256 Mycoplasma mycoides subsp. mycoides SC str. PG1
NP_661261 235 -ATDDVHFSAVLLTLDte-tGKAVGIKRIFY 263 Chlorobium tepidum TLS
EDZ38552  247 -ASGELLFCALLVEFQksesGWAVTGSRLIR 276 Leptospirillum sp. Group II '5-way CG'
CAJ71096  231 -AENDVRMNGVKIVVDsq-tGRAESIMRIEV 259 Candidatus Kuenenia stuttgartiensis
NP_212639 234 -VEDDTILQGVIITSNlk-tGRALKIERIQK 262 Borrelia burgdorferi B31
ACN23812  228 -PEGPCKLQGAIFTLDsa-tGLCTGVERVDI 256 Clostridium sp. enrichment culture clone 7-14

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