1E2X,2DI3,3EET,2HS5,3C7J,2RA5,3IHU,1H9T,3BY6,3IC7,1V4R,3EDP,1HW1,3BWG,2EK5,3FMS


Conserved Protein Domain Family
WHTH_GntR

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cd07377: WHTH_GntR 
Click on image for an interactive view with Cn3D
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators
This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.
Statistics
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PSSM-Id: 153418
View PSSM: cd07377
Aligned: 415 rows
Threshold Bit Score: 58.6128
Threshold Setting Gi: 255918050
Created: 29-Sep-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
DNA-binding
Conserved site includes 19 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA-binding site [nucleic acid binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1     # #                      # ##       ##### ##  #         ## ####   
1E2X_A     11 SPAGFAEEYIIESIwnnrfpPGTILPaERELSELIGVTRTTLREVLQRLArdGWLTIQhGKPTKVN 76  Escherichia coli
1H9T_A     11 SPAGFAEEYIIESIwnnrfpPGTILPaERELSELIGVTRTTLREVLQRLArdGWLTIQhGKPTKVN 76  Escherichia coli
NP_295510  28 ALHTRTERTLRAAIgqgrlpQGTRLPgHRALAAALGVSRNTLVDALAQLEieGYVEVRgRSGTRVC 93  Deinococcus radiodurans R1
YP_592966  21 PLHRQLYESYRSAVlggrlrPGQMVPsTRALAMELEISRMPVLTAYAQLLaeGYFETRsGIGTVIS 86  Acidobacteria bacterium Ellin345
YP_607985  21 GKQQGAYQALRDAIlerrllAGAALPsSRTLATRWGLSRGTLEVVFDRLRseGYIERRsGSGSRVC 86  Pseudomonas entomophila L48
AAP03112   19 TIVDVLESRLREDIltgrhpAGSYLPpERTLADGYGVTRTTLKHAFGRLMqaGLLETRhGVGTRVR 84  Streptomyces griseochromogenes
NP_294564  17 PIHLQLAAQLREAAlagqllPGSLLPgTRTLARDLGVTRGVVEAAYALLSadGTLQGEvGRGTRVS 82  Deinococcus radiodurans R1
Q8NS92     16 SIPTQLTEQIRRLVargiltPGDPLPsSRSLSTQLGVSRGSVVTAYDQLAgeGYLSTArGSGTTIN 81  Corynebacterium glutamicum
NP_488778  14 PLHRQVYEELRRAIllgrltSGGKLPsTRSLAQLLGVSRATVTQGYELLLseGYLETIvGSGTFVC 79  Nostoc sp. PCC 7120
NP_485119  14 PASTQLFNQLRFAIasrqypPAYKLPsTRALAMQTGLHRNIISKVYRQLEedGFVESLaGSGIYVR 79  Nostoc sp. PCC 7120

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