Conserved Protein Domain Family
2A5CPDO_AB

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cd07371: 2A5CPDO_AB 
The alpha and beta subunits of the Class III extradiol dioxygenase, 2-amino-5-chlorophenol 1,6-dioxygenase, which catalyzes the oxidization and subsequent ring-opening of 2-amino-5-chlorophenol.
This subfamily contains both alpha and beta subunits of 2-amino-5-chlorophenol 1,6-dioxygenase (2A5CPDO), which catalyzes the oxidization and subsequent ring-opening of 2-amino-5-chlorophenol, an intermediate during p-chloronitrobenzene degradation. 2A5CPDO is a member of the class III extradiol dioxygenase family, a group of enzymes which use a non-heme Fe(II) to cleave aromatic rings between a hydroxylated carbon and an adjacent non-hydroxylated carbon. The active enzyme is probably a heterotetramer, composed of two alpha and two beta subunits. Alpha and beta subunits share significant sequence similarity and may have evolved by gene duplication.
Statistics
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PSSM-Id: 153383
View PSSM: cd07371
Aligned: 10 rows
Threshold Bit Score: 449.995
Threshold Setting Gi: 83701633
Created: 15-Apr-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative metalputative active
Feature 1:putative metal binding site [ion binding site]
Evidence:
  • Comment:based on similarity to other members of the same protein family

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1               #                                                #                       
AAK26519       7 ISGFLAPHPPHMlyaenppqneprsnggweqlrwayerarasvealKPDVLLVHSPHWITsvGHHFIGVPELSGrsVDPI 86  Pseudomonas putida
YP_785084      4 VSAFLVPGSPLPqlrpdvapwgrfr--------dalrqvgrslarsRPDCVLVYSTQWFAvlDQLWITRARSTGlhVDEN 75  Bordetella aviu...
AAT35226       8 IAGFLAPHPPHLvygenppqneprsqggwevlrwayerarerldamKPDVLLVHSPHWITsvGHHFLGVPELSGksVDPI 87  Comamonas testo...
BAB03531       7 ISGFIAPHPPHLvygenppqnepkstggweqlrwayerarasieelKPDVLLVHSPHWITsvGHHFIGVDHLQGrsVDPI 86  Pseudomonas sp.
YP_785083      7 LAGFLAPHPPHLvygenppqneprseggweplrwayaqaresiarlKPDVLLVHSPHWITqvGHHFLGVPRLSGrsVDPI 86  Bordetella aviu...
YP_559855      7 LSGLLAPHPPHLvygenppqneprsqggweplrwaydqvreniehlKPDVLIVHSPHWITqvGHHFLGVPRLTGrsVDPI 86  Burkholderia xe...
AAK26520       4 VSAFLVPGSPLPqlradvsgwhnfq--------qamrqagaalkesRPDVVLIYSTQWFAvlDEIWLTRRHSEDihVDEN 75  Pseudomonas putida
YP_001967697   4 VSAFLVPGTPLPqlkpevpswgqla--------aateragkalaasRPDVVLVYSTQWLAvlDQQWLTRPRSEGvhVDEN 75  Comamonas sp. C...
ABC41268       4 VSAFLVPGTPLPqlkpevpswgqla--------aateragkalaasRPDVVLVYSTQWLAvlDQQWLTRPRSEGvhVDEN 75  Pseudomonas putida
AAB71524       7 ISGFLAPHPPHMlyaenppqneprsnggweqlrwayerarasvealKPDVLLVHSPHWITsvGHHFIGVPELSGrsVDPI 86  Pseudomonas pse...
Feature 1                                                                                        
AAK26519      87 FPNLFRFDYSMKVDVDLAEACYEEGRNVGLETKmmrNPRFRVDYGTITTLHMIRPQwdIPVVSISANNtpyYLSMEEGLT 166 Pseudomonas putida
YP_785084     76 WHEFGEQPFDIYSDAQLAHRCVQACNEAGIKTRsvdYDQFPIDTGTITASTLMNFGteDLPVITAANNl--YHSAAQTEQ 153 Bordetella aviu...
AAT35226      88 FPNVFRYDFSLNVDVELAEACAEEGRKAGLVTKmmrNPKFRVDYGTITTLHLIRPQwdIPVVGISANNspyYLNTKEGMS 167 Comamonas testo...
BAB03531      87 FPNLFRFDYSINFDVELSEACCEEGRKAGLVTKmmrNPRFRPDYGTITTLHMIRPQwdIPVVSISANNtpyYLSMEEGLG 166 Pseudomonas sp.
YP_785083     87 FPNLFRYDFGMDVDVELAEACCEEAAHLGLVSKmmrNPRFRPDYGTITTLHMIRPQwdIPVVGISANNtpyYLNTKEGLG 166 Bordetella aviu...
YP_559855     87 FPNLFRYDFGMNVDVELAEACCEEATKLGLVSKmmrNPSFRVDYGTITTLHMVRPQwdIPVVGISANNtpyYLNTKEGLG 166 Burkholderia xe...
AAK26520      76 WHEFGELPYSLFSDVDLANACVEACRSQGVPARgadYKAFPIDTGTIVACTAMGIGteALPLVVASNNl--YYNGEATEN 153 Pseudomonas putida
YP_001967697  76 WYEFGDLAYDIRADTALAEACVTSSPLHGVHARgvnYDGFPIDTGTITACTLMGIGtdAFPLVVGSNNl--YHSGEITEK 153 Comamonas sp. C...
ABC41268      76 WYEFGDLAYDIRADTALAEACVTSSPPHGVHARgvnYDGFPIDTGTITACTLMGIGtdAFPLVVGSNNl--YHSGEITEK 153 Pseudomonas putida
AAB71524      87 FPNLFRFDYSMKIDVDLAEACYEEGRNVGLETKmmrNPRFRVDYGTITTLHMIRPQwdIPVVSISANNtpyYLSMEEGLT 166 Pseudomonas pse...
Feature 1                                                                                        
AAK26519     167 EMDLLGKATLEavrksgKRAVLLASNSLSHWHFHqepeppedmtkehpesLAGYQWDMRMIDLMRRGQMQEVFRLLPqfi 246 Pseudomonas putida
YP_785084    154 LGSIAACALQD------KRVAVLGIGGLSNSMFReaidvh----edhiisEGDDAWNKRLLALIEDGDLPALRASLPeys 223 Bordetella aviu...
AAT35226     168 EMDVLGKATREairktgRKAVLLASNTLSHWHFHeeptipedmskeypatMAGYQWDIRMIELMRQGKTSEVFKLLPqfi 247 Comamonas testo...
BAB03531     167 EMDVLGKATREailksgKRAVLLASNTLSHWHFHeepvppedmskehpqtKIGYEWDMRMIELMRQGRMEEVFQLLPqfi 246 Pseudomonas sp.
YP_785083    167 EMDVLGRATREairktgRRAVLLASNTLSHWHFHeepalpedmtkehperYDGYKWDVRMIDLMRQGRMKEAFALLPqfi 246 Bordetella aviu...
YP_559855    167 EMDLLGRATREairktgRRAVLLASNTLSHWHFHeepalpedmskehperYDGYLWDVRMIELMRKGHMKEVFELLPqfi 246 Burkholderia xe...
AAK26520     154 IGAIAAKAALDq----gKRVAVIGVGGLSGSVFTsqidpl----ddhivkPEEDEWNRQILSLLESGNLPALKEQIPhyv 225 Pseudomonas putida
YP_001967697 154 LAALAVDCAKDq----nKRVAVVGVGGLSGSLFReeidpr----edrianEEDDKWNRRVLKLIEAGDVSALREAMPvya 225 Comamonas sp. C...
ABC41268     154 LAALAVDCAKDq----nKRVAVVGVGGLSGSLFReeidpr----edrianEEDDKWNRRVLKLIEAGDVSALREAMPvya 225 Pseudomonas putida
AAB71524     167 EMDLLGKATLEavrksgKRAVLLASNTLSHWHFNqepeppedmtkehpesLAGYQWDMRMIDLMRRGQMQEVFRLLPqfi 246 Pseudomonas pse...
Feature 1                                                      
AAK26519     247 eEAFAEVKSGAFTWMHAAMQYpeLAAELHGYGTVIGTGNAVMEWNL 292 Pseudomonas putida
YP_785084    224 kAARPDMGLKQLHWLLGAMGDryQQAVVHEYGPLYGSGGAVVEFKL 269 Bordetella avium 197N
AAT35226     248 dEAFAEVKSGAFTWMHAAMQYpeLAAELFGYGTVIGTGNAVMEWDL 293 Comamonas testosteroni
BAB03531     247 eEAFAEVKSGAFTWMHAAMQYpnLPAELHGYGTVIGTGNAVVEWNL 292 Pseudomonas sp.
YP_785083    247 dEAFAEVKSGAFTWMHAAMGYpeLAGRLHGYGTVIGTGNAVIEWNL 292 Bordetella avium 197N
YP_559855    247 eEAFAEIKSGAFTWMHAAMGYpeLAGKLHGYGTVIGTGNAVIEWNL 292 Burkholderia xenovorans LB400
AAK26520     226 kAARVDMGFKHFNWVLGAIGGefRSAKVYHYGAIYGSGAAVVEFNL 271 Pseudomonas putida
YP_001967697 226 kEARVDMGFKHLHWILGALKGkfSGANVLGYGPSYGSGAAVIEFRL 271 Comamonas sp. CNB-1
ABC41268     226 kEARVDMGFKHLHWILGALKGkfSGANVLGYGPSYGSGAAVIEFRL 271 Pseudomonas putida
AAB71524     247 eESFAEVKSGAFTWMHAAMQYpeLAAELHGYGTVIGTGNAVMEWNL 292 Pseudomonas pseudoalcaligenes

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