3BCZ,3BD0


Conserved Protein Domain Family
MEMO_like

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cd07361: MEMO_like 
Click on image for an interactive view with Cn3D
Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility.
This subfamily is composed of Memo (mediator of ErbB2-driven cell motility) and similar proteins. Memo is a protein that is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility. It is required for the ErbB2-driven cell mobility and is found in protein complexes with cofilin, ErbB2 and PLCgamma1. However, Memo is not homologous to any known signaling proteins, and its function in ErbB2 signaling is not known. Structural studies show that Memo binds directly to a specific ErbB2-derived phosphopeptide. Memo is homologous to class III nonheme iron-dependent extradiol dioxygenases, however, no metal binding or enzymatic activity can be detected for Memo. This subfamily also contains a few members containing a C-terminal AMMECR1-like domain. The AMMECR1 protein was proposed to be a regulatory factor that is potentially involved in the development of AMME contiguous gene deletion syndrome.
Statistics
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PSSM-Id: 153373
View PSSM: cd07361
Aligned: 202 rows
Threshold Bit Score: 110.744
Threshold Setting Gi: 149921267
Created: 10-Apr-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putative ligandputative metal
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:putative ligand binding pocket/active site [active site]
Evidence:
  • Structure:3BCZ_A, Human Memo binds glycerol, contacts at 4A.
    View structure with Cn3D
  • Comment:Based also on site directed mutagenesis studies; mutations reduced the binding affinity of MEMO to a phosphorylated ErbB2 peptide.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1               #                                             #                          
3BCZ_A         5 EASHAGSWYTASGPQLNAQLEGWLsqvqs-------------tkrpARAIIAPHAGYTYCGSCAAHAYkqvd-------p 64  human
NP_104441     27 PPGTENFPPFYDDATLFRDAIASVatipp-------------snqrLTGITVPHHLLAADLVALGFHAvsg--------- 84  Mesorhizobium l...
YP_001938838  15 YASCHGFSYPSDALACLKHFRSFFevpgacswpk--erltagekkeTLAILAPHIDFQVSPKAYTYAFspwfs------m 86  Methylokorus in...
ZP_03497319  104 PMRLAGLSYPQGEKEARAFLEAFRaaypg-------------egkeAEVLLLPHLEPARIPEAYGAALavler------t 164 Thermus aquatic...
YP_001614483 113 MAAHAGGAYHGDRRKLADFIERKClqvarpqggatraaasqgaparMVGLCAPHMDLWRAAAGYGHAYaaleqalagpgl 192 Sorangium cellu...
YP_466512     21 PPACAGAVYPDAPGALRRALDRWLalpagap---------aappapRGVVVAPHIDYARGAAGYAHAYrale-------a 84  Anaeromyxobacte...
YP_002955715 114 ETVFAGQAYPDAGDELAAYLDAVLaeapea----------ctapgpIKAVIAPHIDPEAGRAAYAAAYaalgaa---ika 180 Desulfovibrio m...
YP_001278255 115 QPALAGQSYPANPADLRRLLDGYVaavgqv----------tpapptGRGVLSPHIDYERGGRVYAQVWqraae-----mv 179 Roseiflexus sp....
YP_823036    113 EPAHAGSAYPGEAEEVNAMMREYMggvep------------pepdgLFAIAAPHVSPEGGWQSYRAAYgmlrp------e 174 Solibacter usit...
NP_213919    104 EPSHAGQAYPENPQELKNFIEETVnkns--------------ekfkARGILVPHMDLRVASGVYGSVYsaik-------e 162 Aquifex aeolicu...
Feature 1                    #                                                   #               
3BCZ_A        65 sitRRIFILGPSHHvplsrCALSSVDIYRTPLYDLRIDQKIYGELWKTgXFERxsl--qtDEDEHSIEXHLPYTAKAXes 142 human
NP_104441     85 fryKRIVILSPDHFhkthkLYATTARGFDTVLGPVAADSDAVRLLEAHgDMVEes---clFDKEHGVRAMLPFLHHYFp- 160 Mesorhizobium l...
YP_001938838  87 aeaDFFILLGVGHHsr--iEWSIDPRDYITPLGRAYNKRDLVEEINRKvDFCLtdp--laHQKEHSIEFPIVFMQALRyw 162 Methylokorus in...
ZP_03497319  165 pepERIYLVGVAHRpl-eaKAAALPVPFHTPFGPMEPDLPALQALDALlPYELfnt-plaFREEHSLELPLFFLKGRYp- 241 Thermus aquatic...
YP_001614483 193 eqvDTFVLLGTSHAam-rrPYAVCEKTFATPLGPLEPDREMIAELAAAsRFDVred-qylHKNEHSIEFQAVFVRHLLgg 270 Sorangium cellu...
YP_466512     85 sraDLFVIFGTAHAtp-prPFTLTRLDYGTPLGPVRTDRALVDALCGAlGEDAllgdelcHRDEHSIELQAVVLAHRLr- 162 Anaeromyxobacte...
YP_002955715 181 aapKRVIVLGVGHQii-dgLFCLTDKAFATPLGDVGADAEAVARLRAAgGRSVdas-tlpHKAEHSVEFQAVFLRHLLgd 258 Desulfovibrio m...
YP_001278255 180 raaEIVILIGTDHYsp--ePITLTRQRYATPFGVLPTDAAIVDALAHAlGEEAafagelyHRVEHSLELAAVWLQYVRgn 257 Roseiflexus sp....
YP_823036    175 hkdRTFVVLATSHYge-peKFGLTRKAFRTPLGDARSDTALVDWLAKHgGAGVkme-dycHSFEHTVELQVIFLQHMLg- 251 Solibacter usit...
NP_213919    163 neyDTVVLLGVSHYfh-etPFSVLPLDLRTPLGDLKVDIERVEELQKMfDYDLshd-vlaYKNEHSIEFQTIFLKYLFp- 239 Aquifex aeolicu...
Feature 1                                                                     #  #               
3BCZ_A       143 h--kdEFTIIPVLVGal---------------seSKEQEFGKLFSky--laDPSNLFVVSSDFCHWGqrfrysyydesqg 203 human
NP_104441    161 -----EAKIVPVAMSvka--------------krGDWDRLAEALKpi---vDQDTLIVESTDFSHYLpq----------- 207 Mesorhizobium l...
YP_001938838 163 mgiqkPLCFLPVLCGglheliiy----dngreelLRMKKLASILReilsfyKKKVGLVLSIDGCHIGprfghpfk--vte 236 Methylokorus in...
ZP_03497319  242 -----KARLVPLLVGrr---------------gpELGEALRVVLK------DHPGLVVLAVDLSHVGprfgdgp---lsr 292 Thermus aquatic...
YP_001614483 271 ----rAASIVPILCGlsecqar-----rrdpaqdDGAESFLRALRdalakrPGRVLVIAGADLAHVGprfgdpap--lde 339 Sorangium cellu...
YP_466512    163 ----rPFTVLPVLCSaighlad------paaataPFLDALARAVA------GRSVCWVAGADLAHVGprygdarp--pap 224 Anaeromyxobacte...
YP_002955715 259 ----aPFAMVPVLCGspagvmdaptrqafrdcagPFLDALAELAS------QPDTLIVAGVDFCHIGgkfghae---pae 325 Desulfovibrio m...
YP_001278255 258 ----pPCPVIPILVGsfaryig-----gedpatdRRLEALMTALRqv--mdTRRTLVVISGDMSHVGpafggap---lse 323 Roseiflexus sp....
YP_823036    252 ----aDVKILPVLIGgfahsiye----ggmpeddDKVRAFFDALSelrereGDKLFWVMGVDMAHMGaryqdsfaarage 323 Solibacter usit...
NP_213919    240 -----EVKVIPAIVSygdt-----------kslkEIAHKITKVLEd-----SQNPLIISSVDFSHVGrkfgd-------- 290 Aquifex aeolicu...
Feature 1                                                #                                       
3BCZ_A       204 eiyrSIEHLDKXGXSIIeq-ldPVSFSNYLkkyh---ntiCGRHPIGVLLNAITelqkngxnxsFSFLNYAQSSqc-rNW 278 human
NP_104441    208 ---hDSRRFDQQTLNMLaa-gsLDGIAALRqpd-----haDSVGALYIQTKLQRelf----gaqPLVVANENSQehtsDY 274 Mesorhizobium l...
YP_001938838 237 emlkNTDLWEKELWRHVee-qnFEGFISHLqkekn-irffDGVGAIALTMEIFKdqk-----vsLRRTYYEQWFe---GR 306 Methylokorus in...
ZP_03497319  293 plaeEARRRDLGFLERLaq-gePEAALAFLgenptridatEVVGSLAPLLRGRR----------GEVLAHRLDLe---AP 358 Thermus aquatic...
YP_001614483 340 rqrtALRDRDLASIERAts-idAPGFFVDVardla-srrvCGLGPIYTLLRALPps------srGEMLHYEQCVd---PE 408 Sorangium cellu...
YP_466512    225 aelaALAAADRRTLRYVea-gdPAGFHRDAvrdga-rrrlCGIAPIYAALRSAGa---------GARLLHYQQW----TD 289 Anaeromyxobacte...
YP_002955715 326 aleaAALAHDRALLAALga-gdADAFWAESarvgd-aynvCGLSALATLAEILPps-------sMTLLSHDIMRe---TP 393 Desulfovibrio m...
YP_001278255 324 sdkaALRRSDEQVIDRMra-gdAAGFFRVIadtgd-rqniCGLPPTYVALRLMGav-------eGELAGYAQCPa--dDE 392 Roseiflexus sp....
YP_823036    324 gemeAVASRDEQRIERIna-ldAGGFWELVrerqd-dlkwCGSSPFYTFLKTAPka-------rGELLSYEQWN----ID 390 Solibacter usit...
NP_213919    291 phsyDPSPRDREYINLLaelknEEAFNLLQsdnn--rtriDGQFTNFVFLEILKnlg----vkeGKLLDYDVYHe---AP 361 Aquifex aeolicu...
Feature 1                    
3BCZ_A       279 QDSSVSYAAGAL 290 human
NP_104441    275 VERTTSYVVALF 286 Mesorhizobium loti MAFF303099
YP_001938838 307 DSSVVTFSSGYI 318 Methylokorus infernorum V4
ZP_03497319  359 TLSAVGAGTLAF 370 Thermus aquaticus Y51MC23
YP_001614483 409 EGSIVSHTSLGF 420 Sorangium cellulosum 'So ce 56'
YP_466512    290 GVDSVSFAAAAG 301 Anaeromyxobacter dehalogenans 2CP-C
YP_002955715 394 TLSAVSFAAAAF 405 Desulfovibrio magneticus RS-1
YP_001278255 393 GTSVVSICGMVF 404 Roseiflexus sp. RS-1
YP_823036    391 ENSVVSFAGMGF 402 Solibacter usitatus Ellin6076
NP_213919    362 TDSKVSYAGMVF 373 Aquifex aeolicus VF5

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