2KBR,3K1R,2KBQ


Conserved Protein Domain Family
harmonin_N
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cd07353: harmonin_N 
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N-terminal protein-binding module of harmonin
Harmonin is a postsynaptic density-95/discs-large/ZO-1 (PDZ) domain-containing scaffold protein, which organizes the Usher protein network of the inner ear and the retina. Harmonin contains a single copy of this domain, which is found at the N-terminus of all three harmonin isoform classes (a, b and c), and which preceeds the first PDZ protein-binding domain, PDZ1. This harmonin_N domain binds specifically to a short internal peptide fragment of the cadherin 23 cytoplasmic domain; cadherin 23 is a component of the Usher protein network.
Links
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Statistics
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PSSM-Id: 259819
Aligned: 8 rows
Threshold Bit Score: 120.64
Created: 3-Apr-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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cadherin 23
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:cadherin 23 binding site
Evidence:
  • Structure:2KBR_A; human harmonin N-domain binds an internal peptide of cadherin 23; contacts at 4 A.
  • Comment:this harmonin N-domain specifically binds a short, completely conserved, internal peptide (KPDDDRYLRAAIQEYDNIAK) of the cytoplasmic domain of cadherin 23.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         # ##  ##            ##  #  ## ##  #                              #            
2KBR_A         2 DRKVAREFRHKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVGDLKLVINEPSRLPLFDAIRPLIPLKHQVEYDQLTPR 80  human
NP_001035018   2 ERKVAREFRHKVELLIDNEAEKDYLYDVLRMYHQSMDLPVLVGDLKLVINEPKRLPLFDAIRPLIPLKHQVQYDQLTPK 80  zebrafish
NP_001089894   2 ERKIAREFRHKVEKCIDNEAEKDYLYDVLRMYYQSMNLPVFVGDLKLVINDPFRLPLFDAIRPLIPLKHQVEYDQLTPK 80  African clawed frog
3K1R_A         2 DRKVAREFRHKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVGDLKLVINEPSRLPLFDAIRPLIPLKHQVEYDQLTPR 80  human
2KBQ_A         2 DRKVAREFRHKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVGDLKLVINEPSRLPLFDAIRPLIPLKHQVEYDQLTPR 80  human
EEN53534      45 EKQIARQFRQKVQAQLEDESERDTLYTSLRQYHESMSLPELITDLRKVVNSPDRMELFEDVRRKARIVKLVKNGPDSLG 123 Florida lancelet
EDO47717      13 ITQHAEEFKNKVNVSIDTEEEKSAFYQALKTYHESGSITQFINDIKSVINTPKRYPLYKDIRKSHLQEALLENSNMIMK 91  starlet sea anemone
ELU05743      75 NLDELRQCLRLVGLILEEAAQRDALYSAMRQYQESRDIHQLIQELKMVLNEPSLLELYEDIRYTIKNSPSRFLASRASS 153 Capitella sp. I ...

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