3F5C


Conserved Protein Domain Family
NR_LBD_Dax1

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cd07350: NR_LBD_Dax1 
Click on image for an interactive view with Cn3D
The ligand binding domain of DAX1 protein, a nuclear receptor lacking DNA binding domain
The ligand binding domain of the DAX1 protein: DAX1 (dosage-sensitive sex reversal adrenal hypoplasia congenita critical region on chromosome X gene 1) is a nuclear receptor with a typical ligand binding domain, but lacks the DNA binding domain. DAX1 plays an important role in the normal development of several hormone-producing tissues. Duplications of the region of the X chromosome containing DAX1 cause dosage sensitive sex reversal. DAX1 acts as a global repressor of many nuclear receptors, including SF-1, LRH-1, ERR, ER, AR and PR. DAX1 can form homodimer and heterodimerizes with its alternatively spliced isoform DAX1A and other nuclear receptors such as SHP, ERalpha and SF-1.
Statistics
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PSSM-Id: 132764
View PSSM: cd07350
Aligned: 7 rows
Threshold Bit Score: 297.504
Threshold Setting Gi: 149642520
Created: 31-Mar-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putative ligandputativeheterotrimer
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:predicted based on homologous proteins.
  • Citation:PMID 9744270

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                 ##   #                                 #   #  #        
3F5C_B        29 PRAPWWDASPgvqrl---itlkdPQVVCEAASAGLLKTLRFVKYLPCFQILPLDQQLVLVRSCWAPLLMLELAQDHLHFE 105 house mouse
Q9BG93       231 PRAPWWDTSSgalrp---valknPQVVCEAASAGLLKTLRFVKYLPCFQVLPLDQQLVLVRNCWASLLMLELAQDRLQFE 307 rhesus monkey
Q8AY13        68 QEVRQQACSCgstrrr--gvlrsPQVTCKAASAVLVKTLRFVKNVPCFRELPEDDQLVLIRSGWAPLLVLGLAQDRVDFE 145 Nile tilapia
Q9PUJ8        28 PRGSGPGCSCgargrgrgrsraaAGGERAAAAAVLVKTLRFVKGVPCFQQLPLAEQLVLVRAAWAPLLVLGLAQDGVALP 107 American alligator
XP_001506358  78 LDNSALLQLIpsfiislrgrervWEGARARARAVLLKTQRFVQGVPCFLALPPADRLVLLRAAWTPLLALGLAQDGVVPG 157 platypus
BAF52037      43 TGVYGQGCSCgaqkk---vslksPQLTCKAASAVLVKTLRFVKNVPCFQELPLDDQLLLVRSCWAPLLVLGLAQDKVDFE 119 African clawed ...
BAB85864      44 SRLYGQGCSCgsqkk---vtlksPQVTCKAASAVLVKTLRFVKSVPCFQELPLEDQLLLVRSCWAPLLVLGLAQDKVNFE 120 Rana rugosa
Feature 1              #                                               #                         
3F5C_B       106 MMEIPETNttQEMLTtrrqetegpepaepqate----qpqmvsaeaghllpaaaVQAIKSFFFKCWsLNIDTKEYAYLKG 181 house mouse
Q9BG93       308 TVEVSEPSmlQKILTtrrretggdeplpvptlq----hhlappaearkvpsasqVQAIKCFLSKCWsLNISTKEYAYLKG 383 rhesus monkey
Q8AY13       146 TTETVEPSmlQRILTgcpdrqseavgg---------------qnrgapgvsvvdIEAIKAFLKKCWsVDISTKEYAYLKG 210 Nile tilapia
Q9PUJ8       108 AHEAAQPSmlQRILTarppp-----------------------------ppaadLQALHGVLAKCWsLDIGPKEYAYLKG 158 American alligator
XP_001506358 158 GLQAPRSSvlRSILTrrppp-----------------------------aaprhLRAVEAFLAHCWtLGVTSREYAYLKG 208 platypus
BAF52037     120 TVETSEPSmlQRILTtrqegerkqqlqqqdsl------lgspqhklshlpsaaeIRWIKEFLDKCWnLDISTKEYAYLKG 193 African clawed ...
BAB85864     121 TVETSEPSmlQRILTnsqggenklhhehseqdflfgnsqhqqhnklsqlpsateIRWIKEFLEKCWsLAISTKEYAYLKG 200 Rana rugosa
Feature 1                                                                                        
3F5C_B       182 TVLFNPDLPGlqcVKYIEGLQWRTQQILTEHIrmmqreyqiRSAELNSALFLLRFINSDVVTELFFRPIIGavsMDDMML 261 house mouse
Q9BG93       384 TVLFNPDVPGlqcVKYIQGLQWGTQQILSEHTrmthqgphdRFIELNSTLFLLRFINANVIAELFFRPIIGtvsMDDMML 463 rhesus monkey
Q8AY13       211 AVLFNPDLEGlrcLHYIQSLRREAHQALNEHVrlihredttRFAKLLIALSMLRAISPPVVAQLFFRPVIGtvnIEEVLM 290 Nile tilapia
Q9PUJ8       159 AVLFNPDLPGlqcTQYIQGLQREAQQALNEHVrlihrgdqaRFAKLNIALSLLRSINANVIAELFFRPIIGtvnMDDMLL 238 American alligator
XP_001506358 209 TVLFNPDLPGlrsVRYVRGLHLEARRALDEQVrsvhrgdhaRVAQLNAALGLLTAIPAHAVAELFFRPVVGavaVDDVLL 288 platypus
BAF52037     194 IVLFNPELPGlhcIQYIQGLQHEAQQALNEHIkmihrweqtRFSKLMIVLSFLRTVNANAIAELFFRPIIGsvnMDDMLL 273 African clawed ...
BAB85864     201 IVLFNPGLPGlhcAQYIQGLQQEAHQALNEHVkmiqrwdnaRFTKLIIVLSLLRSINANAISELFFRPIIGtvnMDDMLL 280 Rana rugosa
Feature 1         
3F5C_B       262 E 262 house mouse
Q9BG93       464 E 464 rhesus monkey
Q8AY13       291 E 291 Nile tilapia
Q9PUJ8       239 E 239 American alligator
XP_001506358 289 E 289 platypus
BAF52037     274 E 274 African clawed frog
BAB85864     281 E 281 Rana rugosa

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