Conserved Protein Domain Family
NR_LBD_SHP

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cd07349: NR_LBD_SHP 
The ligand binding domain of DAX1 protein, a nuclear receptor lacking DNA binding domain
The ligand binding domain of the Small Heterodimer Partner (SHP): SHP is a member of the nuclear receptor superfamily. SHP has a ligand binding domain, but lacks the DNA binding domain, typical to almost all of the nuclear receptors. It functions as a transcriptional coregulator by directly interacting with other nuclear receptors through its AF-2 motif. The closest relative of SHP is DAX1 and they can form heterodimer. SHP is an orphan receptor, lacking an identified ligand.
Statistics
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PSSM-Id: 132763
View PSSM: cd07349
Aligned: 5 rows
Threshold Bit Score: 384.556
Threshold Setting Gi: 82126047
Created: 31-Mar-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative ligandputativeheterotrimer
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:predicted based on homologous proteins.
  • Citation:PMID 9744270

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                           ##   #                                 #   #  #           
Q15466     32 VPRPRSRCLCrqhrpVQLCAPHRTCREALDVLAKTVAFLRNLPSFWQLPPQDQRRLLQGCWGPLFLLGLAQDAVTFEVAE 111 human
Q6PEG7     45 YKRVPQTCHCekrrrVCLQTPSETCALASDVLVKTVYFMKNLPAFQQLPPKDQLKLLQNCWTPLFILGLAQDRVHFQVDE 124 zebrafish
Q501K8     61 ICSLARECPCegnrrVSLKNPEVTCKTASEVLLKTVAFIRNVPSFYQLPQEDQILLVQNCWAPLFVLGLAQERVNFELQE 140 western clawed frog
Q5ILG8     28 HSPPHQRCLChqrwtVCLRTPHITCQAASDVLVKTISFMKNLPSFHLLPRGDQLLLLDSCWVPLFLLGLVQEMVTFEVME 107 chicken
NP_068804  32 VPRPRSRCLCrqhrpVQLCAPHRTCREALDVLAKTVAFLRNLPSFWQLPPQDQRRLLQGCWGPLFLLGLAQDAVTFEVAE 111 human
Feature 1        #                              #                                             
Q15466    112 APVPSiLKKILLeepsssggsgqlpdrpqpslaaVQWLQCCLESFWsLELSPKEYACLKGTILFNPDVPGlqaASHIGHL 191 human
Q6PEG7    125 SAAPSmLKRILLsgqesagad-----seqptlagVQTLKSCINKFWsLDLSPKEYAYLKGTVIFNPDVPDlkaSLFVEGL 199 zebrafish
Q501K8    141 HSVPSlLKKILLnqyanvsdial-rsdrgvpaieVQRIQRFLYKLWnLDISTKEYAYLKGMLLFNPDISGmtfPHYVHTL 219 western clawed frog
Q5ILG8    108 TPAPSmLEKILLdgqskrqep----ewtqpmlaaVQWLQCSLNTFWsLDLSPKEYAYLKGAILFNPDVPGltaSCTSRAS 183 chicken
NP_068804 112 APVPSiLKKILLeepsssggsgqlpdrpqpslaaVQWLQCCLESFWsLELSPKEYACLKGTILFNPDVPGlqaASHIGHL 191 human
Feature 1                                                                    
Q15466    192 QQEAHWVLCEVLepwcpaaqgRLTRVLLTASTLKSIPTSLLGDLFFRPIIGdvdIAGLLGDML 254 human
Q6PEG7    200 QYEAQQALKEVLvplypqdggRFARILLTASTLKSITPSLITELFFRPVIGdaqILDLLADML 262 zebrafish
Q501K8    220 QLEAQHTLMEFIsmmhsqslaRFNWMLQALDTVKEVNPLVITKLFFSPISGeinVEELLLETL 282 western clawed frog
Q5ILG8    184 MREAERALQEVVqilhpkdqdRFALILLITSTLKSIPPALITDLFFRPIIGnadIVELIVDML 246 chicken
NP_068804 192 QQEAHWVLCEVLepwcpaaqgRLTRVLLTASTLKSIPTSLLGDLFFRPIIGdvdIAGLLGDML 254 human

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