Conserved Protein Domain Family
M48_Ste24p_like

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cd07328: M48_Ste24p_like 
M48 Ste24 endopeptidase-like, integral membrane metallopeptidase
This family contains peptidase M48-like proteins that are as yet uncharacterized, but probably function as intracellular, membrane-associated zinc metalloproteases; they all contain the HEXXH Zn-binding motif, which is critical for Ste24p activity. They likely remove the C-terminal three residues of farnesylated proteins proteolytically and are possibly associated with the endoplasmic reticulum and golgi.
Statistics
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PSSM-Id: 320687
Aligned: 126 rows
Threshold Bit Score: 67.1935
Created: 3-Mar-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Zn binding siteputative active
Feature 1:Zn binding site [ion binding site]
Evidence:
  • None

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
NP_250973    201 RLRGELLPLEEPVLhll------greLDRVAAPGLWQWLGQIADRAGAplPDHVVTGIEHCYFVtq---aKVLLAPRGIp 271 Pseudomonas aer...
WP_046776919  81 PLVYILLKSAHRSLffvdetpdastdPAAHEAPALHALVRALTVELHItePVTLRLTGVAAARMtdegsrHLGLSPGRNv 160 Streptomyces sp...
CDN43319      79 VMLRSLRIKFDEPEgi---------vLTPRSAPELYREIESLGKSLQTirIHKVLLTSEFNAAVvqiprlGLLGWHRSYl 149 Paenibacillus s...
WP_034364687  79 NSLRALWLKVDKAEgi---------vLMPEDAPALFEALERIRRKMAGpgIDAVYLTQDFNASIrqvprwGVLGGVRNEl 149 Comamonas testo...
WP_013247650  89 LILRSLWVRIKAPTgy---------rVRQAQCPRLFQEVAHLSSRLQTprIHRILIVNDFNAAIsqvprlGIFGWQRNYl 159 Candidatus Nitr...
GAO02928      78 ALLRAIWVKLERPEge---------rVLPGQAPALFAELERLRRLGRIprIHAVRVDASLNAGVaqtprlGILGWPHNDl 148 Anaeromyxobacte...
WP_035558764  79 KIIRSLWVKFDLPQgr---------aLTPAEAAPLFAALHEQSRALAAppVHRVLLTTDFNASIvqlprlGVLGWPRNYl 149 Hymenobacter sp...
WP_028310039  91 AVIGALAGRLDPPEgi---------kIRPRHAPALFELLRDLCRKLDAreLHRVVITADFNAALvqsprfGLFGGHRNTl 161 Derxia gummosa
WP_018610032  73 LVSAGLLSQLAKSPefpq----ecrrLSGREVPKLYALIEKIRKKIKGpkISAVYLTDDFSLCIrqiprrGILGGQRNVl 148 Uliginosibacter...
ESQ80047      98 DVLRALRVKFEPPKgi---------pVKKRDAPALYAMLKDIRRKTRGprISKVLITEDFNAAImqmprlGVFGWHRNYl 168 Asticcacaulis s...
Feature 1                                  #   #                                                 
NP_250973    272 legrtLYIPLTyasvMSEAESAAIIGHELGHFAAgDTAHGASLsllqrqvrlridriaapevghvg--llgkpglwaaly 349 Pseudomonas aer...
WP_046776919 161 l---sVGLPLLa--vLTREQVRAVVAHELAHLALgHHRSRAFTarletslaafsesmtqlaevnrfvamyagyprllvgv 235 Streptomyces sp...
CDN43319     150 ----mLGLPLMq--aLSPDEFRAVLAHEMAHLSRsHSKFHGWIyrvrriwgqliekleekdsgw------ivlfkrfldw 217 Paenibacillus s...
WP_034364687 150 ----sLGLPLMm--aQDRNRLLAVLAHEYGHLRGgHGKFGAWVyrtrlswtrlyegmqgdsgva------sfatrrflhw 217 Comamonas testo...
WP_013247650 160 ----mLGLPLLl--eLSTEQARAVLAHELGHLSGnHSRFGGWIyrvrlswcriqdafaqmnhrs------wevparflew 227 Candidatus Nitr...
GAO02928     149 ----vLGLPLMl--sLSPESFQAVLAHELGHLSGrHGRAGAWIyrvratwlrllealdgrrsvl------arplraffrw 216 Anaeromyxobacte...
WP_035558764 150 ----mVGLPLLq--aLSPEQAAAVVAHELGHLRGgHGRFSAWVyrvsqsweqllgqleshgag--------twlskfanw 215 Hymenobacter sp...
WP_028310039 162 ----aIGLPLLc--aLDREELAAVIAHELAHITE-AMPLQARLyrqrgtfvalrqrarlrlrdtga--msaciarrmfdg 232 Derxia gummosa
WP_018610032 149 ----qVGLPLLq--lLSRKEFAALLAHEFEHISGhQDGLSAWIyrlrnnwsellhhlppghllh-------riawaplra 215 Uliginosibacter...
ESQ80047     169 ----lLGLPFLm--aMDEHEVRAVVAHEYGHLVGaHGKLSAWVyrvrqtwarlsyafdgggmg--------fvlkrffrw 234 Asticcacaulis s...
Feature 1                        #                                                               
NP_250973    350 fldrferaylhWNRRQELAADKVGARVAGarvfAIALLRTCAlaglierllaspqtrnlvh---------------altd 414 Pseudomonas aer...
WP_046776919 236 hrwlfrglvqpLRRRQELEADALAATVCEapvlADALAKSALadvlwphy------------------------------ 285 Streptomyces sp...
CDN43319     218 ygpklnaytfvLARENEYEADRLAAEAAGsrsmADALVKLRVqhaqldrkfwpevdklaqaqqapppvysmmqqffeqpp 297 Paenibacillus s...
WP_034364687 218 yfprflartfaMARQDEYEADKAAAGLLGqavmADALVEIDLrqqwlqqkfwplhwrsarkqpvpmgp--ysamkywlaq 295 Comamonas testo...
WP_013247650 228 yasyftaysfaLARANEYEADRIAAVLTSphktASALVAVAAlptldheqyweplckrsgaeptppdtavsefarhvqhr 307 Candidatus Nitr...
GAO02928     217 ygpffgaaslaLAREQEREADRFSAVAAGpraaADALAAVAVagwavdrrfwpamnrrtageaepppg-ylgaleaevha 295 Anaeromyxobacte...
WP_035558764 216 yvprfnawshpMRRADEFEADAAAGRVTSpralAQALCALVVrdsaidklhwdvvtagisaqpyppadaisrllplaksa 295 Hymenobacter sp...
WP_028310039 233 iapwyeprslvLARRHEIEADALAARTVGattvARALVRIELveswm--------------------------------- 279 Derxia gummosa
WP_018610032 216 fipyfeafsfvMARRSELQADRLGGAVVGkrlmADALISQELgrrfld-------------------------------- 263 Uliginosibacter...
ESQ80047     235 ygpwfnaysfvLARANEYEADRVSARVAGshtaACALARTSVeghryeqhwqalmahnrvaetpaagp--ytalalrfae 312 Asticcacaulis s...
Feature 1                                #                
NP_250973    415 hlrgnsleldeqdsaRRLEHPFDSHPPt----yQRIADLSL 451 Pseudomonas aeruginosa PAO1
WP_046776919 286 -------rrtyleqgPEGFLPADPFPGf-----ARIVAAPG 314 Streptomyces sp. fd2-tb
CDN43319     298 aypnpdmerslkdalRMETEFDDTHPSl----hDRLDALGE 334 Paenibacillus sp. P22
WP_034364687 296 pvkpafarqalkaslRLKSGLEDTHPVl----rERVDALTG 332 Comamonas testosteroni
WP_013247650 308 tldptqygrllskliSRKTNLSDTHPSl----pDRLSALGA 344 Candidatus Nitrospira defluvii
GAO02928     296 alrdpgagraleralQRRSRGVDTHPAl----aERIAALGQ 332 Anaeromyxobacter sp. PSR-1
WP_035558764 296 rlddategdllktalAADPDVFDTHPVl----lERLAALGE 332 Hymenobacter sp. IS2118
WP_028310039 280 ----------qerfwPGLYAHADSQPLpp--wlPHVSMVRH 308 Derxia gummosa
WP_018610032 264 ---------eqfwpnLWAQAAYSDHPTfaphtlMRTAQSAG 295 Uliginosibacterium gangwonense
ESQ80047     313 pfeiadrarilsgalRETTDIHNTHPCl----sDRLTALGE 349 Asticcacaulis sp. YBE204

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