1YTY,1S29,2CQK


Conserved Protein Domain Family
LAM

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cd07323: LAM 
Click on image for an interactive view with Cn3D
LA motif RNA-binding domain
This domain is found at the N-terminus of La RNA-binding proteins as well as in other related proteins. Typically, the domain co-occurs with an RNA-recognition motif (RRM), and together these domains function to bind primary transcripts of RNA polymerase III in the La autoantigen (Lupus La protein, LARP3, or Sjoegren syndrome type B antigen, SS-B). A variety of La-related proteins (LARPs or La ribonucleoproteins), with differing domain architecture, appear to function as RNA-binding proteins in eukaryotic cellular processes.
Statistics
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PSSM-Id: 153396
View PSSM: cd07323
Aligned: 61 rows
Threshold Bit Score: 69.8681
Threshold Setting Gi: 225565535
Created: 2-Oct-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
RNA binding
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:RNA binding site [nucleic acid binding site]
Evidence:
  • Structure:1YTY_A ; human La bound to UUUoh 3'-termini of nascent RNA Pol III transcripts; contacts at 4A.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1               #  ##    #  ## #                        ###                               
1YTY_A         14 EAKICHQIEYYFGdfNLPRDKFLKeqik-----ldeGWVPLEIXikFNRLNRLTTDfNVIVEALSKSka----elXEISE 84   human
EER12121       40 VADVKRQVEYYFSddNLRHDAFFHrkis----edpeGWLPADLVlsCNKMKQMHCTaENIEHALAEGs------hLELKK 109  Perkinsus mar...
EEY68786       11 RKRLQRQLEFYLSesNLRQDKFLQqam------daqGFVPVREFlsFNKLKSLKATeRMILDEADKSs------tIRVDR 78   Phytophthora ...
CAZ29574       14 DLKILRQVEFYLSegNLNRDSFFKqemq----krddGGIPIDLLlkCNRMIAMNVTeDILKNVVGTSk------iLKLSN 83   Schistosoma m...
EEA98447       77 KQRIKRQVEYYLSdeSLAYDAFFQskmreaaqqgkgESLDLRFVlsSPRIKSLNLTkAEILAAIADSv------aVKVKE 150  Toxoplasma go...
XP_001705495    7 PRNALTQLEYYFSnyNITRDKWMLdklr----estdQSIELSVVndFPKLKAYGLTpEQLRDAAIDSp------vIEVSS 76   Giardia lambl...
EER16456        7 TSKVDRQVNFYFSdeNLRRDVYLRgll------kspEGLPVTTLltFPLLRRHQAAkDEVMPALEKVcat--sqyVELSS 78   Perkinsus mar...
EER05644       26 YEKVKVAVEGVLSkeYLKSNPSFAsrm------naqMYMSLDSLfnVKAIEDLNTTvEEIADAISSLgs----skVALDS 95   Perkinsus mar...
CAZ35668      532 LDYIRHHVEYYFSesNLQRDSHLRailt-----anqDVCPLTELlqFNRLRWVSATeSELLDAVSSSnv----llVVLSP 602  Schistosoma m...
EER00097      391 FGAIRRQVEWWLNkpNWDKDEHLRslay-----pgtHWIPVQELmkFERLRDLSDDqAEVVHVLRTErcgkqdprLEVSP 465  Perkinsus mar...
Feature 1                    
1YTY_A         85 d----kTKIRR 91   human
EER12121      110 dn--dkLFIRR 118  Perkinsus marinus ATCC 50983
EEY68786       79 arcciaPKVVP 89   Phytophthora infestans T30-4
CAZ29574       84 d----gLAIVR 90   Schistosoma mansoni
EEA98447      151 ead-gtTLLYR 160  Toxoplasma gondii ME49
XP_001705495   77 d-----LRVKR 82   Giardia lamblia ATCC 50803
EER16456       79 e-----EFVRP 84   Perkinsus marinus ATCC 50983
EER05644       96 t----rTLIKP 102  Perkinsus marinus ATCC 50983
CAZ35668      603 dg--spTGITR 611  Schistosoma mansoni
EER00097      466 d----gYYVRH 472  Perkinsus marinus ATCC 50983

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