2E6V,2A6X,1R1Z


Conserved Protein Domain Family
lectin_leg-like

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cd07308: lectin_leg-like 
Click on image for an interactive view with Cn3D
legume-like lectins: ERGIC-53, ERGL, VIP36, VIPL, EMP46, and EMP47
The legume-like (leg-like) lectins are eukaryotic intracellular sugar transport proteins with a carbohydrate recognition domain similar to that of the legume lectins. This domain binds high-mannose-type oligosaccharides for transport from the endoplasmic reticulum to the Golgi complex. These leg-like lectins include ERGIC-53, ERGL, VIP36, VIPL, EMP46, EMP47, and the UIP5 (ULP1-interacting protein 5) precursor protein. Leg-like lectins have different intracellular distributions and dynamics in the endoplasmic reticulum-Golgi system of the secretory pathway and interact with N-glycans of glycoproteins in a calcium-dependent manner, suggesting a role in glycoprotein sorting and trafficking. L-type lectins have a dome-shaped beta-barrel carbohydrate recognition domain with a curved seven-stranded beta-sheet referred to as the "front face" and a flat six-stranded beta-sheet referred to as the "back face". This domain homodimerizes so that adjacent back sheets form a contiguous 12-stranded sheet and homotetramers occur by a back-to-back association of these homodimers. Though L-type lectins exhibit both sequence and structural similarity to one another, their carbohydrate binding specificities differ widely.
Statistics
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PSSM-Id: 173892
View PSSM: cd07308
Aligned: 49 rows
Threshold Bit Score: 95.1122
Threshold Setting Gi: 72392036
Created: 26-Sep-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
metal bindingcarbohydrate
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:metal binding site [ion binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
2E6V_A         6 LKREHSLIKpyqgvgsssmpLWDFQGSTILtsQYVRLTpdersKEGSIWNHQPCFl-kDWEMHVHFKVhgtgkknlhGDG 84  dog
XP_001329346  10 SVTSSDLSPpykqdnegkinYWELRGGALLedSSILLSppiqyTRGGVWSVVEIPk-dDFSITYDFKIseg----tqGGG 84  Trichomonas vag...
XP_001321449  11 AKTVADVAPpyqldkngkigLWEYSGATVPtdEGIIVVpplqhRKGCLWTDVEIPsdtMWLINYTLQIpr-----veGGQ 85  Trichomonas vag...
XP_001329453  11 SENINDLAPpfqedlhgnigTWSFAGSFVIlkDIIMLTppvqhKFGCAWTRADIPe-tDWSANFNFRVhkg----tgGGG 85  Trichomonas vag...
XP_001304257  12 FEQSADLIPpfypnsnnqigYWNIGGAAIIeeGKIILAppiqyRKGSAWSSLPLPy-gDWQITFDLKIsqg----ngGGG 86  Trichomonas vag...
XP_001310010  10 LSEEYGLRApfqlssdnkigYWEFAGSTIVfnDSIQLVppiqfKRGCAWTNLEIPr-kDWRISYDFRFseg----dlGSQ 84  Trichomonas vag...
XP_001307120  11 CKSLLDLQEpfrldenstinTWSFFGNTQIysDQIVLLppirrSKGSMWSKAILPd-dSWSIRVDLTViqp----heELS 85  Trichomonas vag...
XP_001316492  12 DLESYNLNPpfkltglteigDWSVIGSAAIikKYIRLTsavteVEGGVCHRKPTQf-eNWTVDFTLKGyng----ngGAG 86  Trichomonas vag...
XP_001329944  11 TDSEYQLSVpflrtlpgeigNWTLRGQAVAqkRVIHLTtaipsVFGGICSRTPTNa-kDWSTNLDFSLd--------QDE 81  Trichomonas vag...
XP_001303190  10 QSITYNLYPpfkntapgefgLWSVAGSTSNakNHIHITsrknkINGALCSRIPTSy-qNFETVLNVSLi--------SGS 80  Trichomonas vag...
Feature 1                                     #                                                  
2E6V_A        85 IALWYTRdrlvpgpvfgskdnFHGLAIFLDTypndet-----tervfPYISVMVNNGslsydh---skdgrwTELAGCTA 156 dog
XP_001329346  85 LGFWFISdyaaygelfggpdtFNGCALLAGIkkles------sdrleLRLSYAENDGtkkv-------sagdLAAADYVL 151 Trichomonas vag...
XP_001321449  86 FGFWFISkygaqgnlaggpqkFDGIAILAQVaqked-------gkfgFYLNYFENDGtkai-------npedISKNGVFV 151 Trichomonas vag...
XP_001329453  86 LGIWLVEnygsygelhggpatYKGLLVSITIrdndde-----mnthsLIFHVIENNGvdkinvtliesdfemQFHHRYDI 160 Trichomonas vag...
XP_001304257  87 FAIPIITthss-------dgpFYGISDKFSGivlvgavfadnegnptVHYNIYQSDGsktfkv----mqdidPCLKSIPL 155 Trichomonas vag...
XP_001310010  85 IGLWFVDkygdegelaggpqvFKGIAVIISLveke--------eknfLDFYFIQNRGiqtin------msdlKPVQSLEY 150 Trichomonas vag...
XP_001307120  86 FALFYTSdaasdtsfnggpsaFKGLAIIGEFirine-------ttkkFTLNSLQSDGs--------------IDLRTVAL 144 Trichomonas vag...
XP_001316492  87 FNFTYSYdfcpe-----nnedATGFTLFINTttr----------yslCPIYIIEGRHlksmnsq-apidmekAKIGDFDF 150 Trichomonas vag...
XP_001329944  82 FYITLSRnvcpd-----pqswFSGMNITFVPlen-----------gsVSFSVKGNEVi--------------PPRTNIID 131 Trichomonas vag...
XP_001303190  81 FHYLFTQdacpivh-rynggyWRGFSLNFNEsne----------klnISFTIVRNDYt-------------yNTQDLCLI 136 Trichomonas vag...
Feature 1                                                                                        
2E6V_A       157 DFrnrdhdTFLAVRYs---rGRLTVMTdle-dknEWKNCIDITGVRlp--------------tgYYFGASAGTGd----- 213 dog
XP_001329346 152 QFdnr-nhIILKIEFf---qNELVISGtsdgkieNIVEFFRVQRRIdi--------------teNYFGVTSQSDi----- 208 Trichomonas vag...
XP_001321449 152 DFsrr-apFQISIQFl---kNKIGVYSpmh--tiNKGIILEAFLKRdi--------------sqNYIGMTAQTDy----- 206 Trichomonas vag...
XP_001329453 161 PFrm--eiSDGKIRLycsgeNESNPPL-------ILEKAINISLKQ------------------KYLGITAASEe----- 208 Trichomonas vag...
XP_001304257 156 DNe----nFKVTLSIf---nKTINATHtds--kgQKTLITDAPITIdi--------------skCWIGISAMCDdytski 212 Trichomonas vag...
XP_001310010 151 RIgs---vFNVAIELn---lQTIDIKIgk---lkTEKLIYSSDLNVdi--------------tqNYIGVTAINGqnfakv 207 Trichomonas vag...
XP_001307120 145 PNp----dLTFDVEDd----FTFGLIFg-----iSNNQIYTAVDPGdgqlirgsrqkaefdyseFYLGLTAQNKayesgl 211 Trichomonas vag...
XP_001316492 151 RGee---pINIRITRa---gNLISLKFir----gYYITNFEREIQNlp--------------svGYFSIKSYTTk----- 201 Trichomonas vag...
XP_001329944 132 NFnfs-kqHTVQIVKk---gRNIEISY-------ENELQFNVSTFGay--------------dqTYFSFFAQSPv----- 181 Trichomonas vag...
XP_001303190 137 NTtn---pVIKVKSGe----NEATVQYfd---gnKWKDCGSKHVFPyl--------------vvGYFTLTAFPIe----- 187 Trichomonas vag...
Feature 1                                         
2E6V_A       214 ------------------lSDNHDIISMKLFQL 228 dog
XP_001329346 209 ------------------yTSRFDLYSVLFDLY 223 Trichomonas vaginalis G3
XP_001321449 207 ------------------yTMRLDLLDIKFDVN 221 Trichomonas vaginalis G3
XP_001329453 209 ------------------mTSRVDLNYVKFTQG 223 Trichomonas vaginalis G3
XP_001304257 213 -------------emfnatFNTDDMISNRRKQA 232 Trichomonas vaginalis G3
XP_001310010 208 el----------ldlfihlLNNHEISSKRKVAM 230 Trichomonas vaginalis G3
XP_001307120 212 llsklqlsmegdisdkshdMDNFYQPETHTNTN 244 Trichomonas vaginalis G3
XP_001316492 202 ------------------wADDNDLLDFKVTQL 216 Trichomonas vaginalis G3
XP_001329944 182 -------------------KCNRCITNIHGFTY 195 Trichomonas vaginalis G3
XP_001303190 188 ------------------eFAQARIYSFNTSIP 202 Trichomonas vaginalis G3

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