2K4T,3EMN


Conserved Protein Domain Family
Porin3_VDAC

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cd07306: Porin3_VDAC 
Click on image for an interactive view with Cn3D
Voltage-dependent anion channel of the outer mitochondrial membrane
The voltage-dependent anion channel (VDAC) regulates the flux of mostly anionic metabolites through the outer mitochondrial membrane, which is highly permeable to small molecules. VDAC is the most abundant protein in the outer membrane, and membrane potentials can toggle VDAC between open or high-conducting and closed or low-conducting forms. VDAC binds to and is regulated in part by hexokinase, an interaction that renders mitochondria less susceptible to pro-apoptotic signals, most likely by intefering with VDAC's capability to respond to Bcl-2 family proteins. While VDAC appears to play a key role in mitochondrially induced cell death, a proposed involvement in forming the mitochondrial permeability transition pore, which is characteristic for damaged mitochondria and apoptosis, has been challenged by more recent studies.
Statistics
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PSSM-Id: 132767
View PSSM: cd07306
Aligned: 62 rows
Threshold Bit Score: 129.636
Threshold Setting Gi: 145351915
Created: 4-Mar-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putativeputative
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:putative dimerization interface [polypeptide binding site]
Evidence:
  • Comment:VDAC may dimerize via a small hydrophobic interface. Various oligomerization states have been proposed

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                # #                                                     
2K4T_A         4 PPTYADLGKSARDVFTKGYgf-gLIKLDLKTKsenglEFTSSGSANTetTKVTGSLETKYRwte-yglTFTEKWNtdNTL 81  human
P04840         3 PPVYSDISRNINDLLNKDFyhatPAAFDVQTTtangiKFSLKAKQPVkdGPLSTNVEAKLNdkq-tglGLTQGWSntNNL 81  baker's yeast
P40478         3 LRFFNDISRDVNGLFNRDFfhtnPLSLNISTTtengvNFTLKAKQGVteGPIQTSVEGRFYdrk-egvSLSQSWSnqNRL 81  baker's yeast
CAX44645       3 PAAYSDLSKASNDLINKDFyhlsTAAVDVKTVapngvTFTVKGKTTKd-DTISASVDAKYLdka-tglTLTQGWNnaNAL 80  Candida dublini...
P07144         3 VPAFSDIAKSANDLLNKDFyhlaAGTIEVKSNtpnnvAFKVTGKSTHd-KVTSGALEGKFTdkp-nglTVTQTWNtaNAL 80  Neurospora crassa
XP_505530      3 PLAFSDIAKASNDLLNKDYyhlaRASLEIKTKapngvAFVAKGKSSQkdGSIAGNLEAKYAdka-ngvTVTQGWTtaNVL 81  Yarrowia lipoly...
XP_001876325   8 PPSWKDLGKSSSDLLGKDYhf-hGTALEVKTQtpsnvAFKVAGTRDSktDAIHGDIEAKWTnka-hglTFTQAWTtsNVL 85  Laccaria bicolo...
NP_594661      3 PPAYAAINKLCNDLLQRDFpv-gATLLSVRTTapngvVFNVSGNQDAk-GVISGKLETSFNdka-nglTISQGWTtaNVL 79  fission yeast
XP_445230      3 PVEFGEISRNAQGVLNRDFfh-gTGGVIQVSTssddfRFNSRGKFSD--GNFGANLSGRHAikg-tgiAVSQSLDnkNQF 78  Candida glabrat...
ABI13166       3 PTAFKDIGKLCSDLLSKDYkt-gSNSVEVKSKvpngiTFTPKADKTG--DKFSGSLAAKSAvpggadlEVTLKTS--GVM 77  Emiliania huxleyi
Feature 1                                                                                        
2K4T_A        82 GTEITVEDqlargLKLTFDSSFspn---tgKKNAKIKTGYKRehINLGCDMDFdiagPSIRGALVLGYEGWLAGYQMNFE 158 human
P04840        82 QTKLEFANlt-pgLKNELITSLtp----gvAKSAVLNTTFTQpfFTARGAFDLclksPTFVGDLTMAHEGIVGGAEFGYD 156 baker's yeast
P40478        82 NTRIEFSKia-pgWKGDVNAFLtp----qsIKNAKFNLSYAQksFAARTSIDIlq-pKDFVGSVTLGHRGFVGGTDIAYD 155 baker's yeast
CAX44645      81 NTKIELSElltpgLKGELDTSVvp----ngARNAKLNFFYQQsaVNARLFFDLlk-gPIATADLVVAHDGFTAGAELGYD 155 Candida dublini...
P07144        81 ETKVEMADnlakgLKAEGIFSFlpa---tnARGAKFNLHFKQsnFHGRAFFDLlk-gPTANIDAIVGHEGFLAGASAGYD 156 Neurospora crassa
XP_505530     82 DSKIEIDEalaqgLKGELATSFvps---sgAKNAKLSLFFKQpsFQARAFFDLlk-gPTVTSDATLGHDGFIAGAEVGYD 157 Yarrowia lipoly...
XP_001876325  86 RNQIEVENqvakgLKLDLHTTLspe---kgHKTAVINSVYKQsgFHTRASLDVfk-gPTFTADTVLGRDGFLIGAEAAYN 161 Laccaria bicolo...
NP_594661     80 ESKVGLSEqfapgLHLNVNTTFspa---taAKTAILNLEHQHplIHTHASVNAl--eRKFLGDFTVGHEGFLAGAEFGYD 154 fission yeast
XP_445230     79 STKFEYNNs---qLRSDVTTNWvpg--tvnIKSSRLGFNYFNalMNSKMSVDLfn-pTKVVGSMTMGYGKMVGGSEVTCD 152 Candida glabrat...
ABI13166      78 SASLEAANmm-kgLSLTLDCETpapgkpglLSSGKGTLDYKTdaLTAKGSYDYy--rGDAHAAASSAFKALTFGACADYS 154 Emiliania huxleyi
Feature 1                                                                                        
2K4T_A       159 taksrVTQSNFAVGYKTDEFQLHTNVND------GTEFGGSIYQKVNKkLETAVNLAWTa--GNSNTRFGIAAKYQIDPd 230 human
P04840       157 isagsISRYAMALSYFAKDYSLGATLNN------EQITTVDFFQNVNAfLQVGAKATMNcklPNSNVNIEFATRYLPDAs 230 baker's yeast
P40478       156 taaglCARYAMSIGYLAREYSFILSTNN------RQCATASFFQNVNRyLQVGTKATLQs-kTSSNMNIEFVTRYVPDSi 228 baker's yeast
CAX44645     156 issakVNKYSVGVGYANLNYGLAATATSn-----LSVFSAAYFHKVSPlVQVGAKATWDs-vKSSNVNVEFATKYALDNt 229 Candida dublini...
P07144       157 vqkaaITGYSAAVGYHAPTYSAAITATDn-----LSVFSASYYHKVNSqVEAGSKATWNs-kTGNTVGLEVATKYRIDPv 230 Neurospora crassa
XP_505530    158 vsdakVTKYSAAVGYTAPVYSTSILATNs-----LSVFSAAYFHRVNPaTEVGAKATWDskaAAAPVGLEIGAKHTLDAn 232 Yarrowia lipoly...
XP_001876325 162 vtegnITRYAAALGYNAPEYAVTVHGLNn-----LKTFTASYYHRVSRdVEAGAKAVYDsksTHGGVALEVGTKAQLDSs 236 Laccaria bicolo...
NP_594661    155 vqkgnVSNYAATIGYLASPLSVALQASNn-----LSVFRASYYHRVSSdVEAGGNVTWDaasTANAITLELASKYALDKd 229 fission yeast
XP_445230    153 iaqnkFTRYALSMGIYAGKRNLTFLIND------AHVMTLTLYQKLSPqFEAAAKTTTRf-nESNKTSVEVATAYRHNS- 224 Candida glabrat...
ABI13166     155 vskssLSKYAAACQYVAPDFTVCAKLNEalgkpgGMVYAGSYYHKVSPkMQVGTEVSKAa--KKDAVSLAFGCQYKLDKd 232 Emiliania huxleyi
Feature 1                                  # #                      #     
2K4T_A       231 ACFSAKVNNsSLIGLGYTQTLKPGIKLTLSALLDGKNvn-----agGHKLGLGLEFQ 282 human
P04840       231 SQVKAKVSDsGIVTLAYKQLLRPGVTLGVGSSFDALKls-----epVHKLGWSLSFD 282 baker's yeast
P40478       229 SQVKAKIADsGLTTLSYKRNLNKDISLGVGMSFNALQlt-----epVHKFGWSLSFS 280 baker's yeast
CAX44645     230 SFIKAKIADsGLTALSYTQELRPGVKLGLGASFDALKla-----epVHKLGFSLSFA 281 Candida dubliniensis CD36
P07144       231 SFVKGKINDrGVAAIAYNVLLREGVTLGVGASFDTQKld-----qaTHKVGTSFTFE 282 Neurospora crassa
XP_505530    233 SFAKAKINNqGIAALAYSVGLKPGVRVGVGASIDTQRle-----qsAHNLGVSFTFE 284 Yarrowia lipolytica CLIB122
XP_001876325 237 AFVKAKINNsGVVALGYTQTLRPGVKASFGVALDTQKlndpspvgpSHKVGVSFVFD 293 Laccaria bicolor S238N-H82
NP_594661    230 TFVKGKINSaGVATLSYFQTVRPGVTVGLGLQLDTQRlg-----qpAHKAGLSLAFS 281 fission yeast
XP_445230    225 AQYKLKLNDaGLACLSYKVPFQKNISLGLGISMDVCNp-------tVKKFGWSLNFQ 274 Candida glabrata CBS 138
ABI13166     233 LTVKGKVDAdGMLSASYKHKLSNISTLTLATVIDTVHlae----ssKHKFGLALNLT 285 Emiliania huxleyi

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