Conserved Protein Domain Family
Porin3_Tom40

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cd07305: Porin3_Tom40 
Translocase of outer mitochondrial membrane 40 (Tom40)
Tom40 forms a channel in the mitochondrial outer membrane with a pore about 1.5 to 2.5 nanometers wide. It functions as a transport channel for unfolded protein chains and forms a complex with Tom5, Tom6, Tom7, and Tom22. The primary receptors Tom20 and Tom70 recruit the unfolded precursor protein from the mitochondrial-import stimulating factor (MSF) or cytosolic Hsc70. The precursor passes through the Tom40 channel and through another channel in the inner membrane, formed by Tim23, to be finally translocated into the mitochondrial matrix. The process depends on a proton motive force across the inner membrane and requires a contact site where the outer and inner membranes come close. Tom40 is also involved in inserting outer membrane proteins into the membrane, most likely not via a lateral opening in the pore, but by transfering precursor proteins to an outer membrane sorting and assembly machinery.
Statistics
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PSSM-Id: 132766
View PSSM: cd07305
Aligned: 53 rows
Threshold Bit Score: 195.12
Threshold Setting Gi: 220067147
Created: 4-Mar-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9QYA2        77 LPNPGTFEECHRKCKELFPVQMe--GVKLTVNKGLSNRFQVTHTVALGtig--------------esnYHFGVTYVGTKq 140 house mouse
ABW76113      10 RTNPGRTDDFQREAKEILTPDLf-dGLRVEIGQSLSQNLGLTHSFVMGsstv-------------pshYQLGANYLRDK- 74  Trimastix pyrif...
XP_725663    100 APNALLFENLNKEYKYITTQDNf-dGFRFEVDKNVNKYLQSTHTLFLGtslrd-----------vgylYQFGANFANSDn 167 Plasmodium yoel...
XP_001612296 104 PYELLVFENLTREFKNVITQDNy-dGFRLEADRQLTNNLQLSHSLYLGtvmse-----------tgylYQIGTNYASSDg 171 Babesia bovis T2Bo
XP_953730     96 PFDLLVYENLAREYKNVITQDNy-dGFRLEADRQLTKNLQASHSLYLGtllkd-----------vgyiYQIGANYASDDg 163 Theileria annul...
XP_002142208   8 PEQSIQYEHFSKEVHNVLQQDNf-dGFRAEIAKNVTRNLQSSHTILLGtird------------kgymYQFGPSYQSADg 74  Cryptosporidium...
XP_628082     15 TNKSLQYENFSLESQSIFQRESf-dGFRAEIAKSVTSNLQTSYSLFLGtsni------------kgysYQLGPSYQSSSk 81  Cryptosporidium...
EEB03476     155 APIPVPYEQFSREWMAVAGQDNf-dGFRLEATKQVNKVLTANHTFMLGtqske-----------ggcsYSFGPTLVIGEp 222 Toxoplasma gond...
XP_642798     39 LPYPGKAEDMISEVKGLVNDDIy-eGAKVDVTFKISPFFETSHQLNVYtpnen----------srtpkYSNQNVYSKDS- 106 Dictyostelium d...
XP_001453416  42 PRRPPLFDGLLNNVRAVTKKVEhikGFKFEVAGGLSNNFHLAHSWMIPpsskgkapnpnpmkqppvpsYTLAAQYLGGEl 121 Paramecium tetr...
Q9QYA2       141 lsp---teafPVLVGD--MDNSGSLNAQVIHQLSp--GLRSKMAIQTQQs--KFVNWQVDGEYRG-SDFTAAVTLGNPdv 210 house mouse
ABW76113      75 ----------IFVTGR--FDHAGRLSGAVRVQPLk--ELASKFEFLLGRs-kAECGCLAEVELRG-RDFTGELQASSA-- 136 Trimastix pyrif...
XP_725663    168 ---------tLLMISR--INLDGSVNGRFCKKINn--FVDCKFNFNTYNksdPRNMYEMSLEVNN-PQNTYNIKTIWQg- 232 Plasmodium yoel...
XP_001612296 172 ---------nCLAMGK--IGLDGMLTGRVFAKYAd-cEFKVSGNSFLRYd--TRNAYEAGVDYFG-KGWTASLKGAWQg- 235 Babesia bovis T2Bo
XP_953730    164 ---------kKFLMFK--VGLDGNIALKAFAKLGd--RLELKAVTNSRLkidNQSTFEVGADYLS-DYWTATLKCCWQg- 228 Theileria annul...
XP_002142208  75 ---------kTMVLSR--IGTDGMVNTRLSRRFGn--NIDCKFSSSSSInheERNMSELSLEYNG-FDWSACIKAAYNg- 139 Cryptosporidium...
XP_628082     82 ---------nTLILAR--VNDEGTVSGRFSRCFGnniEGRISINSSLSDe--NKNMSEVSIDYNG-EESSYSLKVAYQg- 146 Cryptosporidium...
EEB03476     223 deaaqqegqmPNFFGMarMNSDGFLQARFIKAISktfDIKFNSNSSISEdakDKSMYEVSFDKMG-SDWAANLKLAWQg- 300 Toxoplasma gond...
XP_642798    107 ----------TLLYGK--IDSERRLFGRFDQGFFn-nSIRVSLTNMMDKs--FKNNLAGELEFKL-PFMNFCLKADTE-- 168 Dictyostelium d...
XP_001453416 122 rtpf--dqpsYIMTGR--WDSTGKLEAAIIKKLNe--TFNFRFSAFYLDs--SPNNAQVHLDCDIsGEDYVHSIKLGT-- 191 Paramecium tetr...
Q9QYA2       211 lvgsGILVAHYLQSITPCLALGGELVYHrrPGEEGTVMSLAGKYtl--nnWLATVTLGQ--------------AGMHATY 274 house mouse
ABW76113     137 ----GATTARWHQAVTDRVSVVGEGVYH--RAKKVSLLQGGLRFat--pdSVTTLSGSSm-------------GQLITSY 195 Trimastix pyrif...
XP_725663    233 ---aWIFNASYTQLLTKKLQAGVDLTYI--GSNCASIGSFGLRYnh--knHVLTMQCIRqpnfkspefmlnqaHSYKMQY 305 Plasmodium yoel...
XP_001612296 236 ---tWILNAAYTHQLLPCLTLGSELTYI--VANGTSIGAIAARYvr--gdHVFTGQWSKqpnfkgmdynlqdtDTCRLQY 308 Babesia bovis T2Bo
XP_953730    229 ---tFIWNICYTHQILPCFTVGSEVTYI--DANGASIGSLSARYvr--gdNIFTCQLTRqpdfkrmdfskkeiNCARVQY 301 Theileria annul...
XP_002142208 140 ---tGLLNGSYSQVITPKLQLGGELTWI--SANCTSIMAIGSRYri--gkNTIFTQISRqpdfstlqgmlsnsHSIKSSF 212 Cryptosporidium...
XP_628082    147 ---iFLLNGLFSQLITNKLQLGGELTWI--AANNTSIMSLGSRYch--gkNIFFNQITRqpdftspgrifaniHSLRSSF 219 Cryptosporidium...
EEB03476     301 ---tWILNGLFSQVITPKLQLGGELTWV--AATGISMGSVGARYgfn-enNTVTCQIGVgpdfsspmgfandvYSTKAQY 374 Toxoplasma gond...
XP_642798    169 ----NQRGFSFLTSISKKLAIGYENSYLfnHSQSIKQIQFFVNNp----lSTWSLVVGNt-------------AQIGSSY 227 Dictyostelium d...
XP_001453416 192 ----GLYSFNMMQTIGKRLVLGYEMMTL--TERNMSLMSYAFKFginpkqNLYAQYVGAa-------------DQLILAY 252 Paramecium tetr...
Q9QYA2       275 YHKASDqLQVGVEFEASt---rMQDTSASFGYQLDLPkaNFLFKGSVNSNWIVGATLEKKLpPLPLTLSLCAFLNhrknK 351 house mouse
ABW76113     196 THSLTDrLSLATELFMQp---rTHDAIFSVGYQVKLR--KAIVRGMVVSNGRVMASVKDEI-APNTALLLSGDLNylanE 269 Trimastix pyrif...
XP_725663    306 ARKISDrLSVGTELEVTp---eTKESAMRLGWDYSFR--HAKVQGSIDSSGKIAVFTQDYS-GFGVSGYIDYLNN----E 375 Plasmodium yoel...
XP_001612296 309 VRRVNErLSLCTELEVTp---aTKESALRVGWDYLFR--HARVQGNIDTAGRISMQAQDYS-GFGISGCIDYWSN----I 378 Babesia bovis T2Bo
XP_953730    302 TRKVNDrLSLATELELSp---sIKESALRVGWEYLFR--HARVQGNIDSCGRIAMQTQDYN-GFGVSGCIDYWNN----I 371 Theileria annul...
XP_002142208 213 CRKVSDrLSLATELECTw---pNYESSLKLGYEYLFK--TARIQGMIDTGGRLSMQCQDVQ-GFGISGMIDYLKS----D 282 Cryptosporidium...
XP_628082    220 YRKLSDrLSLASELEVSi---pNFESTLRFGYEYLFK--TARIQGMIDTCGKISLQCLDNK-GFGISAAIDYLRN----D 289 Cryptosporidium...
EEB03476     375 VRKVTDrLSMGTELEFTh---pDMSSAMRVGWQYLFR--QARVQGLVDTAGRVSMFAQDYN-GFGLSGMIDYWHG----D 444 Toxoplasma gond...
XP_642798    228 VYRQKN-LHIGTDLVMGisqegKFMSEYSFGVRYAFQ--QSLVKFRADSHGSIFGSYDQMI-NSFTKLNLSGSLNyfaqD 303 Dictyostelium d...
XP_001453416 253 NHRILDkAYFMSELEYSn---qTGESRTILGYRQKFA--TSEVIITINSKMKFSSNLTLQGfAYQLKLCAIADYNk--dS 325 Paramecium tetr...
Q9QYA2       352 FLCGFGLTIG 361 house mouse
ABW76113     270 YKFGLGLILG 279 Trimastix pyriformis
XP_725663    376 YKFGFMMHIA 385 Plasmodium yoelii yoelii str. 17XNL
XP_001612296 379 YRFGFMMHLL 388 Babesia bovis T2Bo
XP_953730    372 YRFGFMMHLL 381 Theileria annulata strain Ankara
XP_002142208 283 YRFGFMMQFM 292 Cryptosporidium muris RN66
XP_628082    290 YKFGFMMQFF 299 Cryptosporidium parvum Iowa II
EEB03476     445 YKFGFQMNVV 454 Toxoplasma gondii ME49
XP_642798    304 YKFGLGLTFQ 313 Dictyostelium discoideum AX4
XP_001453416 326 YKFGYGIAMG 335 Paramecium tetraurelia strain d4-2
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