2W01,1FX4,1YBU,1Y10,1YK9,1WC0,1AB8,3ET6,1CJK


Conserved Protein Domain Family
CHD

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cd07302: CHD 
Click on image for an interactive view with Cn3D
cyclase homology domain
Catalytic domains of the mononucleotidyl cyclases (MNC's), also called cyclase homology domains (CHDs), are part of the class III nucleotidyl cyclases. This class includes eukaryotic and prokaryotic adenylate cyclases (AC's) and guanylate cyclases (GC's). They seem to share a common catalytic mechanism in their requirement for two magnesium ions to bind the polyphosphate moiety of the nucleotide.
Statistics
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PSSM-Id: 143636
View PSSM: cd07302
Aligned: 928 rows
Threshold Bit Score: 68.3747
Threshold Setting Gi: 123412494
Created: 30-Sep-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:nucleotidyl binding site
Evidence:
  • Structure:1WC0; Arthrospira adenylyl cyclase with bound alpha,beta-methyleneadenosine 5'-triphosphate
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1              # ######                                  # ###  #                         
2W01_A         14 PITILTSDLRGFTstseglnpeevVKVLNIYFGKMADVIthhgGTIDEFMGDGILVLFGapts--qqdDALRAVACGVEM 91   Synechocystis...
1WC0_A         27 LITILFSDIVGFTrmsnalqsqgvAELLNEYLGEMTRAVfenqGTVDKFVGDAIMALYGapeemspseQVRRAIATARQM 106  Arthrospira p...
NP_711251     156 NVTVLFTDMAGFTkiaesmspeelLSELDLFFREFDLITkkhgMEKIKTIGDSYMAAGGlpiv--nntHSIDAVLCGLEF 233  Leptospira in...
YP_002430452  292 SVTILFADFVDFTahaekispeelIDDLEASYALFDEIVeargLEKLKTIGDSYMCAGGltvl--nenHAMDCVQAGLDM 369  Desulfatibaci...
ZP_01108263   221 DITVLFTDFENFTklvasisaitlVNELNDIFGRFDEIMaeteVEKIETIGDSYMAACGleke--manHAANCIRAAQMM 298  Flavobacteria...
ZP_01720942   239 NVTVLFADVKNFTivsegllpdqlVALLDTYFQRIDAIIqkhgLEKIKTIGDAYLAAAGvpkg--nkaTARDVVAAALEI 316  Algoriphagus ...
NP_970773     842 AVTVLFADVVGFTewsghntpdavISGLNSLFTHFDGIMdlygCERIKTLGDGYLACSGltn---eknHAERVVDAAVAM 918  Treponema den...
EDZ45152      167 KVSVVMLDFVNFTdfasrtdptvtLGELNDIFTAFDRIVeqygCERIKTIGDAYLAVAGmpep--mpeHATAVAHCATRF 244  Rhodobacteral...
YP_002685691  164 PVSVLMLDFVGFTemvasqdpsvtVTELNDIYSAFDRIGeqfgCERIKTIGDAYITVAGlpdp--tpdHAKAIANTAIRF 241  Rhodobacterac...
YP_001768465  173 DVAVLFIDLVGFTawchrqtpdvvVAEIQRLAEAFEIVAhehgLENIKTIGDAFMATANllrp--hadPVEAAIRCASDM 250  Methylobacter...
Feature 1                                                          ###   ##  ##                   
2W01_A         92 QLALRevnqqvt------glglqpLEMGIGINTGEVVVGNigsekrtkYGVVGAQVNLTYRIESYTtgGQIFISSTTLEA 165  Synechocystis...
1WC0_A        107 LVALEklnqgwqerglvgrnevppVRFRCGIHQGMAVVGLfgsqersdFTAIGPSVNIAARLQEATapNSIMVSAMVAQY 186  Arthrospira p...
NP_711251     234 QKFMRlkkkere------nnhlpfWELRLGIHSGSVVAGVvgtk-kfaYDIWGDSVNTASRMESSGipGEVNISQETFEK 306  Leptospira in...
YP_002430452  370 VESIKaikqarq------alginsWDVRVGIHTGPVVAGVigqt-kfsYDVWGEAVNLASRMEANGipNKVNISEATYLQ 442  Desulfatibaci...
ZP_01108263   299 LSYLEernks----------heikWKMRVGIHSGTVVAGVvgkk-kfaYDLFGDTINTASRIEFAGevGKINISSSTYEQ 367  Flavobacteria...
ZP_01720942   317 QKTNDaykvlre------teglpfFDFRIGINTGTVVAGVvgdk-kyvYDIWGDAVNTAARIEENSapGRVNISAFTHQV 389  Algoriphagus ...
NP_970773     919 LRSLEtfnke----------ndscFSIKIGISSGAITGGIvgvh-kyiFDVFGDTVNTAFRLESVTspTACTVSESTAAL 987  Treponema den...
EDZ45152      245 LRYLErrnqs----------hqhkWQARIGLGTGSAVGSVvgiq-kyvYDVFGPAVNLASRLQVFAnpMKIVAPEEMKAA 313  Rhodobacteral...
YP_002685691  242 VRYLTrrnls----------hphqWQCRIGLSSGSVVGSVvgiq-kyvYDIFGPAVNLASRLQEFSepMQISVQDEVAQV 310  Rhodobacterac...
YP_001768465  251 VAVAAaga--------------pgWRLRAGIHIGSVVGGIvgrt-kftFDLWGDTVNVAARLSGLGggCTLHLSREAFAR 315  Methylobacter...
Feature 1                         #           
2W01_A        166 agdrvhvNGNRTv-QPKGvkdPVVIWDV 192  Synechocystis sp.
1WC0_A        187 vpd-eeiIKREFl-ELKGidePVMTCVI 212  Arthrospira platensis
NP_711251     307 ikd-ffiCDYRGkiKAKNk-gEIDMYLV 332  Leptospira interrogans serovar Lai str. 56601
YP_002430452  443 vkd-qfqCDPRGmiRLKGi-gKAQMYLV 468  Desulfatibacillum alkenivorans AK-01
ZP_01108263   368 ikn-dfkCLSRGkiFAKGk-gDLEMYFV 393  Flavobacteriales bacterium HTCC2170
ZP_01720942   390 vke-hfeLEERGliSAKNk-gKIEMFWV 415  Algoriphagus sp. PR1
NP_970773     988 irg-kygLHKRPdqNLKGk-gLIPCYYV 1013 Treponema denticola ATCC 35405
EDZ45152      314 lse-efrVTDIGpeDIKGi-gEVNLINV 339  Rhodobacterales bacterium Y4I
YP_002685691  311 lkd-qfdIENMGskDIRGf-gEQDVWRL 336  Rhodobacteraceae bacterium KLH11
YP_001768465  316 lad-qraVRPIGnvMLKGk-gEIEVYCR 341  Methylobacterium sp. 4-46

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