Conserved Protein Domain Family
PX_SNX15

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cd07288: PX_SNX15 
The phosphoinositide binding Phox Homology domain of Sorting Nexin 15
The PX domain is a phosphoinositide (PI) binding module present in many proteins with diverse functions. Sorting nexins (SNXs) make up the largest group among PX domain containing proteins. They are involved in regulating membrane traffic and protein sorting in the endosomal system. The PX domain of SNXs binds PIs and targets the protein to PI-enriched membranes. SNXs differ from each other in PI-binding specificity and affinity, and the presence of other protein-protein interaction domains, which help determine subcellular localization and specific function in the endocytic pathway. SNX15 contains an N-terminal PX domain and a C-terminal Microtubule Interacting and Trafficking (MIT) domain. It plays a role in protein trafficking processes in the endocytic pathway and the trans-Golgi network. The PX domain of SNX15 interacts with the PDGF receptor and is responsible for the membrane association of the protein.
Statistics
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PSSM-Id: 132821
View PSSM: cd07288
Aligned: 3 rows
Threshold Bit Score: 251.813
Threshold Setting Gi: 13124562
Created: 30-Jan-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
phosphoinosit..
Feature 1:phosphoinositide binding site [chemical binding site]
Evidence:
  • Comment:A majority of PX domain containing proteins binds phosphatidylinositol-3-phosphate (PI3P) at this site. In some cases, other phosphoinositides, such as PI4P or PI(3,4)P2, are the preferred substrates.
  • Comment:based on the structures of phosphatidylinositol-3-phosphate bound to other members of this superfamily
  • Comment:Two basic residues are key in binding with phosphoinositides: one forms hydrogen bonds with the 3-phosphate of PI(3)P and another forms hydrogen bonds with the 4-and 5-hydroxyl groups of PI(3)P.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                  ###                           ##      
NP_001090475  11 YERRYNVTDTRTnpkGYTEYKITAQfISKKNPQDVkEIVVWKRYSDLKKLHGELSYTHRnlfqrcqEFPPFPRAQVFGRF 90  African clawed ...
AAH53274      10 YYRFFSVTDPRThekGHTEYKVTARfVSKTQPENVkEVVVWKRYTELKKLHGELAYTHRnlfrrqeEFPPFPRAQVFGRF 89  zebrafish
Q9NRS6         9 FLRHYTVSDPRThpkGYTEYKVTAQfISKKDPEDVkEVVVWKRYSDFRKLHGDLAYTHRnlfrrleEFPAFPRAQVFGRF 88  human
Feature 1               #                              
NP_001090475  91 EAAVIEERRQATEEMLQFTVNIpALYNSPQLKEFFREG 128 African clawed frog
AAH53274      90 DEAVIEERRNAAEAMLLFTTNIpALYNSPQLKEFFRDG 127 zebrafish
Q9NRS6        89 EASVIEERRKGAEDLLRFTVHIpALNNSPQLKEFFRGG 126 human

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