Conserved Protein Domain Family
Pat_PLPL

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cd07232: Pat_PLPL 
Patain-like phospholipase
Patatin-like phospholipase. This family consists of various patatin glycoproteins from plants and fungi. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein, but it also has the enzymatic activity of a lipid acyl hydrolase, catalyzing the cleavage of fatty acids from membrane lipids. Members of this family have been found also in vertebrates.
Statistics
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PSSM-Id: 132870
View PSSM: cd07232
Aligned: 27 rows
Threshold Bit Score: 472.521
Threshold Setting Gi: 211969479
Created: 18-Feb-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
active sitenucleophile
Feature 1:active site [active site]
Evidence:
  • Comment:Based on the crystal structure of semet patatin (1OXW)
  • Comment:catalytic dyad is formed by Ser and Asp
  • Comment:oxyanion hole is formed by two Gly and one Arg

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                         
P0C584        330 IEACVKNNFVGIENp---------------rLYSQTYYGTKNLVqny-----vdEVERSIKFLidtk--qltkEQKRVMF 387  Neurospora cr...
Q5KGU2        174 LAVCVRANFAGTESv---------------kMYSETFIGTKKAVeah-----ikEVAACLDYVrtat--dvslEEKRAFF 231  Cryptococcus ...
XP_001837203  209 LETCIRSNFAAVESp---------------rLYSETYLGTKDLIesy-----fsELEKSIVFIrdsp--hlsiDEKRRFF 266  Coprinopsis c...
XP_665308     391 HCREYDNDLQVIDSgfnisk------dvsdrWNSDWGYYYENKVrknyinqfsfETGTGSVLTfsks---egsLASNSLI 461  Cryptosporidi...
EED88794     1145 YGEEVERCLEWVANgpv------------ylGGGEGDDTKMNNVes------ncPREEILQTQqd------elQKRYTLV 1200 Thalassiosira...
EEC45032      334 SRSVVRAYFQQVEEgldwiaeapvlqnlsshQCSEGENGKEAKHmhe----ssrSSSAELTGWaessskhndlLERVTLI 409  Phaeodactylum...
CAL53605      288 LRTVLHRNFAGIDRl---------------lHLRSARVGTKVLVqaf-----ndEIVAAIEYMstt----ddeETAREML 343  Ostreococcus ...
XP_002174092  185 LDVCVRSNFAGLDSp---------------mLYSQTYYGTKKLVdef-----ytEVTECLQLLlten--vfdeYESRRVF 242  Schizosacchar...
XP_001728856  195 LTLCVKQGFAGIENl---------------eLYSQSFYGTKQLIery-----yyEVEESLAYLestp--nvsaPVKSAFY 252  Malassezia gl...
XP_757164     320 LDLCLRNNFAGTENf---------------rLYSETYFGTKYLVesy-----laEIETALEYIektd--kvslETKRSFY 377  Ustilago mayd...
Feature 1                            ## #                          #                              
P0C584        388 KGIc---ANYGRTALCLSGGATFAYYHFGVVKALLEVD--YLPDIITGTSGGALVAALVATRTNDEL-----------KE 451  Neurospora cr...
Q5KGU2        232 RAVn---KHYGSSALCLSGGASFGYYHFGVIKAFLEAD--LLPRVITGTSAGGLCAALLCTRTDSEL-----------KE 295  Cryptococcus ...
XP_001837203  267 KSAn---ANLGTTALCLSGGASFGYYHFGVVKAFFDAG--LLPRVISGTSAGGLIAAFACCYTDEEL-----------KV 330  Coprinopsis c...
XP_665308     462 HYLellgHSTGKTALCLSGGGALAMYHLGVVKVLLEQD--IMPKIINGTSGGSIVAAILATKSNEEIl----------NE 529  Cryptosporidi...
EED88794     1201 KRMk---QNMGHTALMLSGGGAQAMYHLGTIKALVESElyEHIHVISGTSGGSISAAMCAIKSPEELlrdvcvktvstDF 1277 Thalassiosira...
EEC45032      410 RKMk---QNMGRTALMLSGGGAQAMYHLGIIRTLLESKlyQDIKVISGTSGGSIIAAMCATKTPEELy----------NN 476  Phaeodactylum...
CAL53605      344 KVLresyRSLGRTALCLSGGGALAMYHFGVLLTLLRQG--LCPQVISGTSGGSIVAAFLACHSPKDI-----------VT 410  Ostreococcus ...
XP_002174092  243 QYFa---RNFGRTALCLSGGASFSFYHLGVVRALLDEN--LLPSVITGTSGGGLVAALLCTRTNEEL-----------KE 306  Schizosacchar...
XP_001728856  253 RAVf---LNFGRSALCLSGGAAFAYYHIGVARALLDAN--LLPNIVSGTSAGGLIAALLCTRTNEEL-----------KE 316  Malassezia gl...
XP_757164     378 RTVs---KNLGRSALCLSGGASFGYYHIGVVRALLDAN--LLPKVVTGTSAGGLIAALTCTRTDEEL-----------RQ 441  Ustilago mayd...
Feature 1                                                                                         
P0C584        452 LLNPALAHKITACr----------ESFTVWFWRWWKTGARFDSVDWakqcawWCHGSLTFREAYERTGRILNVSCVPSd- 520  Neurospora cr...
Q5KGU2        296 LLVPELADKITACs----------DPFTVWFKRFRQTGARFDTIDWarrsmwFTRGSLTFKEAYTKTGRALNISVVPSd- 364  Cryptococcus ...
XP_001837203  331 MLVPELADKITACe----------ESVTVWMKRFLKTGARFDSCSF------FTRGSMTFKEAYLRTGRILNISVIPAd- 393  Coprinopsis c...
XP_665308     530 YIKPTVSNMHGHRw---------fPPLLDQIRHFLVKGYMIDPKEFikt-cqTYFKNYTFYEAYKLTGRIVTITVSPTyv 599  Cryptosporidi...
EED88794     1278 LLTGEMKRKNIRWf----------PELIHMGTYWLKHRLLVDSTEFkrc-ceFYYKDITFEEAFEMTGKHVCITVTASra 1346 Thalassiosira...
EEC45032      477 ICIPTVVDDFTKTgeqrrenirwfPPVTEMAAYWLKHKLLVDSAYFrrt-cdFYYSDMTFDEAFERTGKHVCITVSASra 555  Phaeodactylum...
CAL53605      411 SIRPDVSTRFGRRw---------fPLPIKMALHFLKHGVLMDEAGFskt-tkAYFGDTTFEEGFAISGLAVSIQVSIG-- 478  Ostreococcus ...
XP_002174092  307 IIVPQMASHFESQm----------GNFMDTIVRYVKTGARFSEVAWartcmwFTRGSMTFAEAYERTGRILNITVVPSd- 375  Schizosacchar...
XP_001728856  317 LLVPDLARHITGCd----------DPMHVWIARAWRTGARFDTSKWarkvqfFTRGSLTFREAFERTGKTLNISVVPFe- 385  Malassezia gl...
XP_757164     442 MLVPALADRITACe----------EPFSVWARRAWATGARFDTVKWaekasfFTMGSMTFKEAYERTGKVLCISVIPAd- 510  Ustilago mayd...
Feature 1                                                                       #                 
P0C584        521 ---pHSPTILCNYLTSPDCVIWSAVLASAAVPGILnPVVLMMKNRDGsl---ePYSFGHKWKDGSLRTDIPIKSLNLHFN 594  Neurospora cr...
Q5KGU2        365 ---rHSPTILLNHLTAPNCLIWSAILASAAVPGILnPVVLMAKDRSGni--kpHNLGGSRFKDGSLREDIPLGSLHTQFN 439  Cryptococcus ...
XP_001837203  394 ---rHSPTKLLNYITAPDTVIWSTLLASAAVPGILnPVVIMQKLKDGti---vPWNWGSRFKDGSLRVDIPLQGLNLYFN 467  Coprinopsis c...
XP_665308     600 t-peFTEPLVLNCITTPDILLWSAVSASCALPGLM-PVAELFAKENHtnkiirYFPPGMKWMDGSISQDIPHKELSTLFN 677  Cryptosporidi...
EED88794     1347 sagsGVQRLLLNHISTPNVTLASAVAASCALPGVMaPAKLMIKDGRGkq--vpFEVDGVEWIDGSVQADLPFKRISTLFN 1424 Thalassiosira...
EEC45032      556 s-ggTAQRLLLNHISTPHVTVASAVAASCALPGVMaPAKLLAKNSSGvl--epFEVDGVEWIDGSVQADLPFQRIATLFA 632  Phaeodactylum...
CAL53605      479 ----SQTGYVLNHLTSPNVLIRTAVCASCALPGLMrPVEILAKDKNGnl--ipFHPPDVKSYDGTITQDIPSARMTELFN 552  Ostreococcus ...
XP_002174092  376 ---vHSPPKIINYLTAPNTIIWSAVIASCAVPGILrPVPLMTRSVDGkl---iPYNFGNRWRDGSLRTDIPLAELRTQFN 449  Schizosacchar...
XP_001728856  386 ---qHSPAQLMNHVTAPDCIVWSAVLASAAVPGILnPVCLLQKLPDGsi---iPWSWGNQFRDGSLRVDIPLESLNSMFN 459  Malassezia gl...
XP_757164     511 ---rHSPVKLLNYVTAPDCVIWSSLLASAAVPGILnPVCLMQKRKGTee--ivPWNWGHRFKDGSLRVDIPLQDLHALFN 585  Ustilago mayd...
Feature 1                                                                                         
P0C584        595 VNFSIVSQVNPHINLFFFssrgsvgqp-vthrkgrgWRGGYLGSATEQYIKLDLTKWLRVLRQLELLPrp-lgQDWSQLW 672  Neurospora cr...
Q5KGU2        440 CNFSIVSQTNPHIHLFFFaprgsvgrp-vahrkgkgWRGGFILSALESYIKLDLSKHFKVIRDLDLMPqi-lqSDWSGVF 517  Cryptococcus ...
XP_001837203  468 VTNPVVSQVNPHVHLFFFaprgsagkp-vahrkgkgWRGNFLLSAAEQWLKHELTKNFKVIRDLELLPtl-lgQDWSSVF 545  Coprinopsis c...
XP_665308     678 VRQFIVSQVNPHHVPFVSvnpin---------tsiiHPERTFLHNVLNWLTLDIKYRYTKLAKLKLIPklfgkDVSNFWM 748  Cryptosporidi...
EED88794     1425 ISNYVVAQTNFHVVPFLNka--------------hhPNINTLYWKIFQMCMWDVQNRVLNLSQLGLFPri-fgQDVTKIF 1489 Thalassiosira...
EEC45032      633 VSSFIVSQTNFHVLPFLNke--------------yhPNQKSLYWQLFQTLEWDIRSRALKLSRLGLFPrl-fgQDISKIF 697  Phaeodactylum...
CAL53605      553 CNNFIVSQVNPHLNFVLHlaeeshgrkqksarsyqrRNAVQKLLRVANFLLLNIKYSIQKLLEVDLLDir-fvRTLQGVL 631  Ostreococcus ...
XP_002174092  450 VHYSIVSQTNPHIQIFFFsprgaigrp-vshrkgqgWRGGYLGSALEQYLKFEMIKWLHVVRSLELLPrp-fgQDWSNVF 527  Schizosacchar...
XP_001728856  460 VTHPIVSQVNPHVHLFHFgsrgapgrp-tafrrgrgWRGGFLLSAAEHILKLNLLTNLAILRDLALLPki-lgQDWSSLF 537  Malassezia gl...
XP_757164     586 VNYPIVSQVNPHVHLFHFgskgspgrp-tahrkgkgWRGGFILSASERILKLNLSMNFKILRDLDLLPai-lgQDWSSVF 663  Ustilago mayd...
Feature 1                                                                          
P0C584        673 LQTFGGTVTIWPKsi--psDFLKILSDPDppRLARMIHEGQQSAFPKVKFIANRLKIERLVERGR 735  Neurospora crassa OR74A
Q5KGU2        518 LQRFSGDLTLTPRst--igDWFHILSDPDrpQMKRMLRVGERVAWPALGMVRNRMTVERAILRGR 580  Cryptococcus neoformans var....
XP_001837203  546 LQRFDGAITIWPRt----rDWIRILSDPDrpELERLLACGQIATWPKLHMIENRTRIEKAIFAGR 606  Coprinopsis cinerea okayama7...
XP_665308     749 LQEIEGHVTITPRvs--lfDWYRCINHPSydDMLHFITEGERRTWPHVMRIKHMNFLEKTIKDTI 811  Cryptosporidium hominis TU502
EED88794     1490 KQKYYGNLTLVPRfttmqiFGLKSLVNPTvaDMEIYLQNGQLAAWPFLRVLKEMLRIEKSIDACL 1554 Thalassiosira pseudonana CCM...
EEC45032      698 KQKYYGNLTIVPRfttmqtFGLKSLSNPTikDMEGYLKYGQIAAWPYLNAIRDMIRLEKALDDCL 762  Phaeodactylum tricornutum CC...
CAL53605      632 MQDFRGHITILPSlt--wtDYSKILLHPTemDMQRYISRGEQSTWPHIEAIRYTMRIEHALVDGI 694  Ostreococcus tauri
XP_002174092  528 LQRFEGTVTIWPKtl--lsDFYYILDPPTeqRLGRMILAGKRASFPKLKFISYRMEVEKLIEQGR 590  Schizosaccharomyces japonicu...
XP_001728856  538 LQKFQGTVTIYPKsr--lkDWPRILTDPDatELAQIIHSGCYVTYPKQHMISHLVRIERAILRGK 600  Malassezia globosa CBS 7966
XP_757164     664 LQRFGGAVTILPKtr--awDWVRILSDPDrkELARMMSVGKSVTFPKLHMIENRVRLERAIEQGR 726  Ustilago maydis 521

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