Conserved Protein Domain Family
Pat_NTE_like_bacteria

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cd07228: Pat_NTE_like_bacteria 
Bacterial patatin-like phospholipase domain containing protein 6
Bacterial patatin-like phospholipase domain containing protein 6. PNPLA6 is commonly known as Neuropathy Target Esterase (NTE). NTE has at least two functional domains: the N-terminal domain putatively regulatory domain and the C-terminal catalytic domain which shows esterase activity. NTE shows phospholipase activity for lysophosphatidylcholine (LPC) and phosphatidylcholine (PC). Exposure of NTE to organophosphates leads to organophosphate-induced delayed neurotoxicity (OPIDN). OPIDN is a progressive neurological condition that is characterized by weakness, paralysis, pain, and paresthesia. This group includes YCHK and rssA from Escherichia coli as well as Ylbk from Bacillus amyloliquefaciens.
Statistics
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PSSM-Id: 132866
View PSSM: cd07228
Aligned: 11 rows
Threshold Bit Score: 255.276
Threshold Setting Gi: 124516488
Created: 23-Feb-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
active sitenucleophile
Feature 1:active site [active site]
Evidence:
  • Comment:Based on the crystal structure of semet patatin (1OXW)
  • Comment:catalytic dyad is formed by Ser and Asp
  • Comment:oxyanion hole is formed by two Gly and one Arg

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1               ## #                        #                                            
EDY37539       4 VGLALGSGGARGWAHIGVIRALQEEGIGISgIAGASIGALVGAMYCAGelddledfvr---dlrwrdlltYFDMVFPTSG 80  Cyanobium sp. P...
NP_623425      5 VGLILGGGAARGYAHLGILKRFEEENIPIDfIVGISMGAIIGAIYASGhnvdklisda--kkinmlkfisLLDFKASRTG 82  Thermoanaerobac...
YP_518902      3 RGLVLGAGGARGLAHLGFLQVLEEESIKVDcIVGCSIGAVFGALWAAGmdlyrlerl----ityqgfskrLWDLAVSRDG 78  Desulfitobacter...
ZP_02203589    9 IGIALGGGAARGIIHIGVLEVLEKEGVPLDlVTGTSMGAIIGALYASGhkpqemkeiv--snlswkqlmpLFDLAAPRAG 86  Dehalococcoides...
YP_002250625   6 IGVALGSGGAKGLSHIGVLKVLEENNVEISfVTGSSIGAIIGALYAKGyspkdieklanniaenkqqfynLFDFSKSLQG 85  Dictyoglomus th...
6648033        6 IGLALGSGGARGLAHLGVLSSLHKHQIEVDmIAGSSMGALVGSFYAAGhdvatmkkv-----akafkrrlYADYTVPKLG 80  Bacillus subtilis
NP_102623     37 ISLALGGGCARGWAHIGVLRALDEAGIEVSmIAGTSIGALVGGCYLAGkldeleefar---sltkrrifgLLDLNLRGSG 113 Mesorhizobium l...
EAY57996      13 IGIALGSGSARGWAHIGVLRSLEEQGIVPDiVCGSSVGALVGAAAATGcmdrletwir---elkrvdvvgYMVRSFMRSE 89  Leptospirillum ...
P67099        17 VALALGSGGARGYAHIGVIQALRERGYDIVgIAGSSMGAVVGGVHAAGrldefahwak---sltqrtilrLLDPSISAAG 93  Mycobacterium b...
P0AFR0        19 IGLALGSGAARGWSHIGVINALKKVGIEIDiVAGCSIGSLVGAAYACDrlsaledwvt---sfsywdvlrLMDLSWQRGG 95  Escherichia col...
AAN80165      19 IGLALGSGAARGWSHIGVINALKKVGIEIDiVAGCSIGSLVGAAYACDrlsaledwvt---sfsywdvlrLMDLSWQRGG 95  Escherichia col...
Feature 1                                                                                 #      
EDY37539      81 LLDGNRVyellse-hmqamrIEDAAIPFCCVATDLIRGkevqlrSGCMVDAVRASISVPGIFTPFcdgdRFLGDGGIVNP 159 Cyanobium sp. P...
NP_623425     83 LVKGEKIekylrg--yvkesFEELNIPLYIVATDIQTGkgvvfkEGDLIKAIRASISIPAFFEPVeyngTKLVDGSIVDS 160 Thermoanaerobac...
YP_518902     79 LVKGEKVleamrl-ltrdltFAELRIPLAVVATDLETGervvfrEGSVAHAVRASISIPGIFKPYryqgRLFVDGAVKNR 157 Desulfitobacter...
ZP_02203589   87 FLSSRKIksylke-ligdvtFSELKKPFACVAADVKTGqevlfnEGSVIDGVIASMSLPIIFRPVknktRFLVDGGIITP 165 Dehalococcoides...
YP_002250625  86 IIKGDKIleyldt-ilegvtFDKLKKPFTPIAVDLITGekvyiqEGKVAEGIRASMSIPVIFQPFswknRLLIDGGVLSP 164 Dictyoglomus th...
6648033       81 FLKGDRVrqlvha-ytfgkpIEELQIPLGIVACDLQTGekivfrKGSVSDAVRASISIPGIFIPQrldgRLLVDGAVVDR 159 Bacillus subtilis
NP_102623    114 LFGGMKLdarlre-hvagvrFEDLPKPFVSVASEIRTGheiwlsNGSLITAMRASYALPGVFEPVncngRMLVDGALVNP 192 Mesorhizobium l...
EAY57996      90 SIQSEKYlgeifgqalaetrIEDLPKRFGSIATDLDTGqevwlrKGSLLSAISPSIAFPGLLNPVhhdgRWLVDGGLVNP 169 Leptospirillum ...
P67099        94 ILRAEKIldavrd-ivgpvaIEQLPIPYTAVATDLLAGksvwfqRGPLDAAIRASIAIPGVIAPHevdgRLLADGGILDP 172 Mycobacterium b...
P0AFR0        96 LLRGERVfnqyre-impeteIENCSRRFAAVATNLSTGrelwftEGDLHLAIRASCSIPGLMAPVahngYWLVDGAVVNP 174 Escherichia col...
AAN80165      96 LLRGERVfnqyre-impeteIENCSRRFAAVATNLSTGrelwftEGDLHLAIRASCSIPGLMAPVahngYWLVDGAVVNP 174 Escherichia col...
Feature 1                            
EDY37539     160 VPVDVARd-lGAELVIAVNL 178 Cyanobium sp. PCC 7001
NP_623425    161 EAIELAAs-lGADIIINCDV 179 Thermoanaerobacter tengcongensis MB4
YP_518902    158 LPIQVAKd-mGAKKVLAVDV 176 Desulfitobacterium hafniense Y51
ZP_02203589  166 IPARVVRn-mGADFVIAVNA 184 Dehalococcoides sp. VS
YP_002250625 165 LPVKDLKmlyKPDIIIAVSL 184 Dictyoglomus thermophilum H-6-12
6648033      160 IPVSVVKd-mGADIIIASDV 178 Bacillus subtilis
NP_102623    193 VPVSVCRa-yEQPLVVAVNL 211 Mesorhizobium loti MAFF303099
EAY57996     170 VPVSLCRa-lGADIVIAVNL 188 Leptospirillum sp. Group II UBA
P67099       173 LPMAPIAg-vNADLTIAVSL 191 Mycobacterium bovis
P0AFR0       175 IPISLTRa-lGADIVIAVDL 193 Escherichia coli K-12
AAN80165     175 IPISLTRa-lGADIVIAVDL 193 Escherichia coli CFT073

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