Conserved Protein Domain Family
Pat_Fungal_NTE1

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cd07227: Pat_Fungal_NTE1 
Fungal patatin-like phospholipase domain containing protein 6
These are fungal Neuropathy Target Esterase (NTE), commonly referred to as NTE1. Patatin-like phospholipase. NTE has at least two functional domains: the N-terminal domain putatively regulatory domain and the C-terminal catalytic domain which shows esterase activity. NTE shows phospholipase activity for lysophosphatidylcholine (LPC) and phosphatidylcholine (PC). Exposure of NTE to organophosphates leads to organophosphate-induced delayed neurotoxicity (OPIDN). OPIDN is a progressive neurological condition that is characterized by weakness, paralysis, pain, and paresthesia. This family includes NTE1 from fungi.
Statistics
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PSSM-Id: 132865
View PSSM: cd07227
Aligned: 4 rows
Threshold Bit Score: 554.411
Threshold Setting Gi: 158563949
Created: 12-Feb-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
active sitenucleophile
Feature 1:active site [active site]
Evidence:
  • Comment:Based on the crystal structure of semet patatin (1OXW)
  • Comment:catalytic dyad is formed by Ser and Asp
  • Comment:oxyanion hole is formed by two Gly and one Arg

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                       ## #                        #                                  
Q04958    1361 RLARILSGQAIGLVLGGGGARGISHLGVIQAIEEQGIPVDvIGGTSIGSFVGGLYAKDydlvpiygrvKKFAGRISSIWR 1440 baker's yeast
Q7S8J1    1200 RLARRLCGKSVGLVLGGGGARGIAHVGIIRAMEEAGIPIDmVGGTSIGAFIGGLYARHadvvpifglaKKFAGRMASMWR 1279 Neurospora crassa
Q5KI53    1304 RIARRLCGQQIGLVLGGGGARGISHIGMLQALEEFGIPIDaIGGCSIGSFVGGLYAREtdlletagrtKQFSGRMGSMWR 1383 Filobasidiella n...
6434012    999 RLARRICGKAIALVLGGGGARGISQIGILYALEEAGIPFDiIGGTSIGAFNGGLYAWEadlvpmfgraKKFCGRMANLWR 1078 fission yeast
Feature 1                                                                                      
Q04958    1441 MLTDLTWPVTSYTTGHEFNRGIWKTFGdtrIEDFWIQYYCNSTNITDSvqeihsfGYAWRYIRASMSLAGLLPPLe-ENG 1519 baker's yeast
Q7S8J1    1280 FAFDLTYPSASYTTGHEFNRGIFKTFGktqIEDFWLEYYCNTTNISKSrvefhtsGYAWRYIRASMSLAGLLPPLc-DEG 1358 Neurospora crassa
Q5KI53    1384 ILSDVTYPFVSYTTGHEFNRGIYKAFYnthIEDFWIPFFANSTNITHSrmevhrtGYAWRYVRASMTLAGLLPPLs-DNG 1462 Filobasidiella n...
6434012   1079 FVLDVTYPQAAYTTGHEFNRGIWKTFGeihIEDFWLPFYANTTNITHSrmdihssGYAWRYIRASMSLAGLVPPMlsDSG 1158 fission yeast
Feature 1          #                                                                           
Q04958    1520 SMLLDGGYVDNLPVTemrarGCQTIFAVDVGSaDDRTPMEYGDSLNGfWIIFNRWNPFSshpniPNMAEIQVRLGYVASV 1599 baker's yeast
Q7S8J1    1359 SMLLDGGYIDNLTVSrmkslGSDVIFAVDVGSlDDNTPQAFGDSLSGvWAFFNRWNPFSsvpnpPTLAEIQARLAYVSSV 1438 Neurospora crassa
Q5KI53    1463 NLLVDGGYMDNTPIQplrenGIRDIIVVDVGSvDDTSPRDYGDSVSGwWIFFNRFNPFYer-rvLSMTEISSRLTYVSSV 1541 Filobasidiella n...
6434012   1159 DMLLDGGYMDNLTVShmqslGASSIFAIDVGSeDSREPMHYGDTVSGvWALISRWIPFIpktsfPSLAEIQSRLTYVTSV 1238 fission yeast
Feature 1                                    
Q04958    1600 NALEKAKntPGVVYVRPPIEEYATLDFSKF 1629 baker's yeast
Q7S8J1    1439 GELERAKtmPGCIYMRPPIDDYGTLDFGKF 1468 Neurospora crassa
Q5KI53    1542 KTLEGVKatPGCHYIAMPVQQFDTLGGFKR 1571 Filobasidiella neoformans
6434012   1239 ATGEKVKsmPGCFYMRPPVKDFPTLEFGSF 1268 fission yeast

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