Conserved Protein Domain Family
Pat_PNPLA6_PNPLA7

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cd07225: Pat_PNPLA6_PNPLA7 
Patatin-like phospholipase domain containing protein 6 and protein 7
Patatin-like phospholipase domain containing protein 6 (PNPLA6) and protein 7 (PNPLA7) are 60% identical to each other. PNPLA6 is commonly known as Neuropathy Target Esterase (NTE). NTE has at least two functional domains: the N-terminal domain putatively regulatory domain and the C-terminal catalytic domain which shows esterase activity. NTE shows phospholipase activity for lysophosphatidylcholine (LPC) and phosphatidylcholine (PC). Exposure of NTE to organophosphates leads to organophosphate-induced delayed neurotoxicity (OPIDN). OPIDN is a progressive neurological condition that is characterized by weakness, paralysis, pain, and paresthesia. PNPLA7 is an insulin-regulated phospholipase that is homologous to Neuropathy Target Esterase (NTE or PNPLA6) and is also known as NTE-related esterase (NRE). Human NRE is predominantly expressed in prostate, white adipose, and pancreatic tissue. NRE hydrolyzes sn-1 esters in lysophosphatidylcholine and lysophosphatidic acid, but shows no lipase activity with substrates like triacylglycerols (TG), cholesteryl esters, retinyl esters (RE), phosphatidylcholine (PC), or monoacylglycerol (MG). This family includes PNPLA6 and PNPLA7 from Homo sapiens, YMF9 from Yeast, and Swiss Cheese protein (sws) from Drosophila melanogaster.
Statistics
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PSSM-Id: 132864
View PSSM: cd07225
Aligned: 17 rows
Threshold Bit Score: 513.488
Threshold Setting Gi: 74621909
Created: 12-Feb-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
active sitenucleophile
Feature 1:active site [active site]
Evidence:
  • Comment:Based on the crystal structure of semet patatin (1OXW)
  • Comment:catalytic dyad is formed by Ser and Asp
  • Comment:oxyanion hole is formed by two Gly and one Arg

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                               ## #                        #                             
Q6ZV29        911 HSDFSRLARVLTGNAIALVLGGGGARGCAQVGVLKALAECGIPVDMVGGTSIGAFVGALYSEERNysqMRIRAKQWAEGM 990  human
NP_001090744  917 HCDFSRLARVLTGNAIALILGGGGARGCSQVGIIKALIESGIPIDLVGGTSIGAFMGALYAEERSfnrMKIRAREWCMDM 996  western clawe...
CAQ13938      880 HSDFSRLARILTGNAIALVLGGGGARGCSQVGIIRAMSEAGIPVDLIGGTSIGSLIGALYAEERSvsrMTVRARQWAMDF 959  zebrafish
XP_001844786  857 HSDFSRLARWLTGNSVGLVLGGGGARGAAHVGMFRAIQEAGIPIDMVGGVSIGAFMGALWCSEKNittVTQKAREWCKKM 936  southern hous...
Q5BK26        930 HSDFSRLARILTGNAIALVLGGGGARGCAQVGILRALAECGIPVDIIGGTSIGAFMGALFAEERSysqIRIRAKQWAEDM 1009 Norway rat
XP_002127361  653 FSDFSRLARFLTGTSIALVLGGGGARGLSQIGILQSLQNAGVPVDMIGGTSIGAFMGGLWAAHRNietMKEKSLILCDDM 732  Ciona intesti...
XP_001202094 1004 MSDFSRLARFLTGTSIGLVLGGGGARGISQLGIIKAMEEYGIPIDIVGGVSIGALISALYAEDVNstiMEKRLQGFCKDF 1083 purple urchin
29337200      935 HSDFSRLARWLTGNSIGLVLGGGGARGAAHIGMLKAIQEAGIPVDMVGGVSIGALMGALWCSERNittVTQKAREWSKKM 1014 fruit fly
XP_001629896  820 SSDFARLARRLTGTSIGLVLGGGGARGLSHVGVIKTLEENGIPVDMVAGTSMGAFVGAAFAEYGDvtkMTQKVREWSWDM 899  starlet sea a...
NP_689499     911 HSDFSRLARVLTGNAIALVLGGGGARGCAQVGVLKALAECGIPVDMVGGTSIGAFVGALYSEERNysqMRIRAKQWAEGM 990  human
Feature 1                                                                                         
Q6ZV29        991 TSLMkaALDLTYPITSMFSGagFNSSIfsvFKDQQIEDLWIPYFAITTDITASAMRVHTDGSLWRYVRASMSLSGYMPPL 1070 human
NP_001090744  997 TSVWkkVLDLTYPTTSMFSGaaFNKSIssiFKDKQIEDLWIPYFNITTDITASAMRIHTDGCLWRYVRASMSLSGYMPPL 1076 western clawe...
CAQ13938      960 GSIFkkITDLTYPVTSMFTGasFNSSIgtlFQDKQIEDLWIPYFNITTDITASSMRVHTDGSLWRYVRASMSLSGYLPPL 1039 zebrafish
XP_001844786  937 TQWGrqLLDLTYPITSMFSGrdFNQTIhgtFGDVCIEDLWIPYFTLTTDISASCARTHTHGSLWRYVRSSMSLSGYMPPL 1016 southern hous...
Q5BK26       1010 TSMVktILDLTYPITSMFSGtgFNSSIsniFKDRQIEDLWLPYFAITTDITASAMRVHTDGALWRYVRASMSLSGYMPPL 1089 Norway rat
XP_002127361  733 SSIVskILDLTYPFTSMFSGasFNRAIhtiFKDIQIEDLWIPYFTITTDITSSEMRVHTDGWLWRYVRASMSLSGYLPPL 812  Ciona intesti...
XP_001202094 1084 GSLWkrVIDLTYPSTAMFTGhnFNKSIsdlFGDKQIEDLWLPYFTISTDITKYALRLHTSGSLWRYVRASMSLSGYLPPL 1163 purple urchin
29337200     1015 TKWFlqLLDLTYPITSMFSGreFNKTIhdtFGDVSIEDLWIPYFTLTTDITASCHRIHTNGSLWRYVRSSMSLSGYMPPL 1094 fruit fly
XP_001629896  900 NSMFtkILDLTYPFTSMFSGdgFNASIrssFGERQIEDLLLPYFCITTDITSSRMRVHTDGSLWRYVRASMSLSGYLPPL 979  starlet sea a...
NP_689499     991 TSLMkaALDLTYPITSMFSGagFNSSIfsvFKDQQIEDLWIPYFAITTDITASAMRVHTDGSLWWYVRASMSLSGYMPPL 1070 human
Feature 1                   #                                                                     
Q6ZV29       1071 CDPKdgHLLMDGGYINNLPADVARSMGAKVVIAIDVGSRDETDLTNYGDALSGWWLLWKRWNPl-ATKVKVlnMAEIQTR 1149 human
NP_001090744 1077 CDPKdgHLLMDGGYINNLPADVARSLGAKVVLAIDVGSRDETDLTNYGDALSGWWLLWKRWNPl-ADRVKVlnMAEIQTR 1155 western clawe...
CAQ13938     1040 CDPKdgHLLMDGGYINNLPADTARSMGAKLVIAVDVGSQDETDLTNYGDSLSGWWLLWKRLNPl-AEKVKVlnMAEIQTR 1118 zebrafish
XP_001844786 1017 CDPKdgHLLLDGGYVNNLPADVMRGQGAAHIIAIDVGSQDDTDLTDYGDDLSGWWLLYKRWNPf-TSPVKVpnLPDIQSR 1095 southern hous...
Q5BK26       1090 CDPKdgHLLMDGGYINNLPADVARSMGAKVVIAIDVGSRDETDLTNYGDALSGWWLLWKRWNPl-ATKVKVlnMAEIQTR 1168 Norway rat
XP_002127361  813 CDPKdgHLLMDGGYLNNLPGDVARARGACKVIAVDVGSETEVDFTDYGDHLSGWWLLWKRWTGrwTGRIKVpdLNDIQSR 892  Ciona intesti...
XP_001202094 1164 CDPKdgHLLLDGGYVNNLPADIMRAMGVPTIIAIDVGSEDTSSITNYGDELSGWWLLWKKWNPw-TEPVRVpsLDEIQSR 1242 purple urchin
29337200     1095 CDPKdgHLLLDGGYVNNLPADVMHNLGAAHIIAIDVGSQDDTDLTNYGDDLSGWWLLYKKWNPf-TSPVKVpdLPDIQSR 1173 fruit fly
XP_001629896  980 CDPKdgHLLLDGGYVNNLPADVMKKMGAQTIIAIDVGSEYHGELMNYGDQLSGWWLLWNRWNPf-AETVRIpdMAEIQSR 1058 starlet sea a...
NP_689499    1071 CDPKdgHLLMDGGYINNLPADVARSMGAKVVIAIDVGSRDETDLTNYGDALSGWWLLWKRWNPl-ATKVKVlnMAEIQTR 1149 human
Feature 1                                                                            
Q6ZV29       1150 LAYVCCVRQLEVVKsSDYCEYLRPPIDSYSTLDFGKFNEIcEVGYQHGRTVFDIWGRSGVLEKMLRD 1216 human
NP_001090744 1156 LAYVCCVRQLEMVKnDDYCEYIRPPIDRYGTLEFGKFDEIcDVGYQHGKTVFNVWGRSGVIDKMLRD 1222 western clawed frog
CAQ13938     1119 LAYVCSVRQLELVKdSDYCEYLRPPIDRYGTLDFGKFDEIaDVGFQHGKTVFDVWCRSGVRETIMKD 1185 zebrafish
XP_001844786 1096 LAYVSCVRQLEEVKkSDYCEYIRPPIDTYKTLAFGSFDEIkNVGFEHGKAFFENMAKCGRLSRFNQW 1162 southern house mosquito
Q5BK26       1169 LAYVCCVRQLEMVKnSDYCEYLRPPIDSYRTLDFGKFDEIcEVGYQHGPAGFDIWVRSGVLEKMLQD 1235 Norway rat
XP_002127361  893 LSYISCHYLLEKVIkSDYCFYVRPPIAKYKTLEFHKHKELyQVGFNHGVKIFTDEWASHFWKELISD 959  Ciona intestinalis
XP_001202094 1243 LAYVSSMKMLDEVKnSSYCEYMRPPINNFATLAFHRHREImEVGYHHGMTVFSGWKKSGYLQALLSE 1309 purple urchin
29337200     1174 LAYVSCVRQLEEVKnSDYCEYIRPPIDKYKTLAFGSFDEIrDVGYVFGKNYFESMAKAGRLGRFNQW 1240 fruit fly
XP_001629896 1059 LAYVSCVQQLEEVReSSNYEYIRPPINRFKTLDFGLFDEIvEVGYQHGKTVIGEWTKKSRLQEILQE 1125 starlet sea anemone
NP_689499    1150 LAYVCCVRQLEVVKsSDYCEYLRPPIDSYSTLDFGKFNEIcEVGYQHGRTVFDIWGRSGVLEKMLRD 1216 human

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