Conserved Protein Domain Family
Pat_like

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cd07224: Pat_like 
Patatin-like phospholipase
Patatin-like phospholipase. This family consists of various patatin glycoproteins from plants. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein, but it also has the enzymatic activity of lipid acyl hydrolase, catalysing the cleavage of fatty acids from membrane lipids. Members of this family have been found also in vertebrates.
Statistics
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PSSM-Id: 132863
View PSSM: cd07224
Aligned: 13 rows
Threshold Bit Score: 238.392
Threshold Setting Gi: 84997595
Created: 12-Feb-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
active sitenucleophile
Feature 1:active site [active site]
Evidence:
  • Comment:Based on the crystal structure of semet patatin (1OXW)
  • Comment:catalytic dyad is formed by Ser and Asp
  • Comment:oxyanion hole is formed by two Gly and one Arg

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1               ## #                           #                                          
ABN08447      148 GFSFSAAGLLFPYHLGVAHFLIQNGYIKEt-TPLAGSSAGAIVCAVVASGasmeea-liatkiLAEDCRKGGTAFRLGAV 225  barrel medic
XP_001693038   83 GFGFSAGGLLFPYFLGISEQLQSMNVLLPe-TPVAGASAGSIIAVCAKSGlseeel-lvafldLARDCRQGGTRTRLKSV 160  Chlamydomonas...
XP_001693123  149 GFGFSAGGFLYPYHLGVLWELHELDILKDykVQMAGASAGSLAVATYNCGlepeka-tqalheFAENCRANGTRYRLGGL 227  Chlamydomonas...
NP_001068065  120 GFSFSAAGLLFPYHIGVAQCLIDRGYLTEr-TPLAGSSAGAIICAVIASGntmrda-lqvtkdLADNCRSNGTAFRLGAV 197  Japanese rice
NP_174597     119 GFSFSAAGLLFPYHLGVAQLLIEKGYIKEt-TPLAGSSAGAIVCAVITSGatmrea-leatkeLAYDCRRNGTAFRLGAV 196  thale cress
CAQ38385      439 GISFSPAGLLIPYHLGVSSLLIEKNILNIh-TSIAGSSAGSICACCLGIGlsvdkc-fflienIISNVYKNGCYQKLQNM 516  Plasmodium kn...
XP_001612104  303 GFSFAPCGCMIPYHLGVLSLLSEMNVINVt-TPLSGGSAGSLTIVTSTSMrpnindlmritegICADVRSNGSYHRLDGL 381  Babesia bovis...
XP_953519     220 GFSFSPCGFLMPYHLGILSYLCDYNVINCt-VPLSGASSGSLSICYSVLKntf--------iyCMNVIDSATTRLRQNSV 290  Theileria ann...
EEB03168     1373 GFSFSPAGLLGPYHLGVLSLLCEANVINQy-TPVAGASAGGLAAAAVGLNlsaatv-mssvehVCRDLIDRGTAHRLGKR 1450 Toxoplasma go...
XP_001758282   59 GFSFSAAGLLFPYHLGVCQCLIENGYITEn-TPLAGSSAGALVCAVIGSGlstyda-lqatkeLALDCRTYGTAFRLGAV 136  Physcomitrell...
XP_667486     143 GFSFSVSAMLIPYHLGVILELQEQGYITEs-TPLSGASGGSIAAICCALDismyea-meacisLYEDCRKNGTAGRLNEV 220  Cryptosporidi...
CAL55288       53 GVGFSAAGFVFPQLVGSWEVLVELGVMREd-TPVAGASAGSLVAALHACGktpadg-krilseVLADTRVNGVVGRVGGV 130  Ostreococcus ...
XP_001743968   21 VIAFSGCGWMLPYHIGVAHGLVAAGRIRQf-TRFAGASGGSLIGAYLACAidpetv-leahlyQSEICRQEGTWWKLRRL 98   Monosiga brev...
Feature 1                                                                                         
ABN08447      226 LRDi--------------LQKFLPDDVHIRSN------GRVRVAVTQLLWRp---------RGLLVDQFDSKEDLINAVF 276  barrel medic
XP_001693038  161 LRRv--------------LEKALPDDIHERCN------GRAHLAVTRLWPEf---------TPQTISSFRSRTDVIDTLL 211  Chlamydomonas...
XP_001693123  228 LKDf--------------LHAYLPDDAHERCR------GNTHVALTRLFPVv---------RSELISEFESKDDFVNALL 278  Chlamydomonas...
NP_001068065  198 LKDv--------------LDRFLPDDVHIRCN------GRIRVAITQLSWRp---------RGLLVDQFDSKDDVISAVI 248  Japanese rice
NP_174597     197 LREs--------------MERLLPDDIHIRSN------GRIRVAITQVFWRp---------RGLLVDQFDSKSDLIDAVF 247  thale cress
CAQ38385      517 LNVe--------------LNKYLYAGSYNFLNrr---nGSVFVGVTQILPYy---------KRLNITRFYDDSDLINAVI 570  Plasmodium kn...
XP_001612104  382 VKDn--------------VDHWMAPGTYMAVNnr---iGELRVAMSARRTFf--------yHGQQISRFNDNVDLRDALR 436  Babesia bovis...
XP_953519     291 DGEnlikgqnldtivkdyLYDTLAEGSNEFINsr---iGKITVAYSVLKHLk--------fRTRSCSNFTSISDLVDCLR 359  Theileria ann...
EEB03168     1451 LRKe--------------LNKLIPEDCAEIIAkr---pGRVTVTYTHVFPYm---------QGEFVSSFLGKSDMIDCLI 1504 Toxoplasma go...
XP_001758282  137 LRNf--------------LEKFLPEDVHLKVN------GKIRVAVTQVFRQp---------RGLLVDFFDSREDLINALL 187  Physcomitrell...
XP_667486     221 LERe--------------LRKKLPDNVIELLNnrsekgGQIIISFTQLLPVp---------KAHFVSDFNSKDDLIECIL 277  Cryptosporidi...
CAL55288      131 LEKa--------------LRANLPTDAHVTCSr-----GNLFVSVSSPRVVqgergiefglDGELVSSFETYDDLIGALL 191  Ostreococcus ...
XP_001743968   99 LEHm--------------MDETLPHNAHIKCS------GRLSVAMTRLWPRpr-------lRPVFVSHFPERQDLINALL 151  Monosiga brev...
Feature 1                                #                                                        
ABN08447      277 TSSFIPGYLApkpaTMFRNRLCIDGGLTLFMPpt-----sAAQTVRVCAFPAGRMGlqgigisp---------------d 336  barrel medic
XP_001693038  212 TSSHIPYWFDgslfTMYRSGVYFDGGITNFIPst-----pTDVCYRISCFPSQQLKafkgisls--------------pd 272  Chlamydomonas...
XP_001693123  279 TSCHIPFYFNgswmTEFRGRFYMDGGVAAFIPrp-----pTPHAVKVCCFPVNEVLatvqdrvaqyervaalldvaispd 353  Chlamydomonas...
NP_001068065  249 TSSFIPGYLAprpaTFFRNRLCIDGGLTLFMPpt-----sASETVRICAFPASRLGlqgigisp---------------d 308  Japanese rice
NP_174597     248 TSSFIPGYLAprpaTMFRNRLCVDGGLTLFMPpt-----aAAKTVRVCAFSASNFKlkgieicp---------------d 307  thale cress
CAQ38385      571 ASCNIPMYLSnnifVNFRNKKCIDGLFSTKKKdfgcpntkTDRIVKVSPFDSDYVGienknns----------------- 633  Plasmodium kn...
XP_001612104  437 ASCNIPGISAag-gVYFRGKRCYDGYFAARIYqhgcldtaANRTVRINPFQMGRFEisllrldnkyvs------pllvsk 509  Babesia bovis...
XP_953519     360 ASSYIPIYSSke-pLIYKGHHCYDGQLGLNKSlgcp-dtdSRRTIRINPYQFTSSSisnqnllnefit------pnltkr 431  Theileria ann...
EEB03168     1505 ASCNIPFYLTkwptVTCRGRQCVDGFFATKHKafgcpdsgALRDIKVVPFYASTIRv----------------------- 1561 Toxoplasma go...
XP_001758282  188 TSCFIPGYLAprpvTMFRNRICVDGGITFFMPpt-----aADKTVRVCAFPLYAPEgispdl------------------ 244  Physcomitrell...
XP_667486     278 ASSTIPFLSVpwptFKCRGKPCVDGYFAVGRGelgclptnAIRTVKVCPLPSAGSSmksnr------------------- 338  Cryptosporidi...
CAL55288      192 ASCHIPLYCGwp-aRRYRDKWCVDGGWHNLTPkp----ltAEKSIRVCPFPLLDAWrkaqpgd----------------- 249  Ostreococcus ...
XP_001743968  152 SSCMVPGYLDaaliSRFRDWYVIDGGTWQLVPr-------IAGAVKVCPFQAPFPRsqgvkldis-------------pe 211  Monosiga brev...
Feature 1                                                     
ABN08447      337 cnpenaSSPRQLLNWALEPAEdvild--rlfefGYLDAAVWAKE 378  barrel medic
XP_001693038  273 tfeqwpYDMGTMLGWAFEPAPedmll--klvekGKRDARSWALV 314  Chlamydomonas reinhardtii
XP_001693123  354 asepwpFSYPQMVSWALVPADddmlr--yminkGRRDARAWAQR 395  Chlamydomonas reinhardtii
NP_001068065  309 cnpenrASPRQLFNWALEPAEdevld--klyelGYLDAAVWADQ 350  Japanese rice
NP_174597     308 cnplnrATSRQLLNWALEPAEdevle--rlfelGYADAATWAEM 349  thale cress
CAQ38385      634 visphmVKYRHLIFLFLCVKNl----------fHRVVDNVWVEK 667  Plasmodium knowlesi strain H
XP_001612104  510 dtyvvhYLRLKCLIKALWERKlt--------yeSSGRDEEWLKE 545  Babesia bovis T2Bo
XP_953519     432 dqflmyYIRLKSLIYQLCLREia--------leNLKMANEFPKE 467  Theileria annulata strain Ankara
EEB03168     1562 -----sAAPQDCINPDLQLQDaq--------ivHYLRAKALLRA 1592 Toxoplasma gondii ME49
XP_001758282  245 npgetrAGMRQLFNWALEPAEdvild--elfdlGFQDALAWVKK 286  Physcomitrella patens subsp. patens
XP_667486     339 --sdviSPHIQSYDWILFSPDsnn------nnaDFTRTRKWIRS 374  Cryptosporidium hominis TU502
CAL55288      250 gtetgdVFAQQASFWAGWGDDdaagllispdaaGGQPRPEWDYT 293  Ostreococcus tauri
XP_001743968  212 ltpdfpYTKRELWSLCYNPADmttar--eihnwGLKAANVWLDT 253  Monosiga brevicollis MX1

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