Conserved Protein Domain Family
Pat_PNPLA4

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cd07222: Pat_PNPLA4 
Patatin-like phospholipase domain containing protein 4
PNPLA4, also known as GS2 (gene sequence-2), shows both lipase and transacylation activities. GS2 lipase is expressed in various tissues, predominantly in muscle and adipocytes tissue. It is also expressed in keratinocytes and shows retinyl ester hydrolase, acylglycerol, TG hydrolase, and PLA2 activity. This family includes patatin-like proteins: GS2 from mammals, PNPLA4 (Patatin-like phospholipase domain-containing protein 4), and iPLA2-eta (Calcium-independent phospholipase A2) from Homo sapiens.
Statistics
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PSSM-Id: 132861
View PSSM: cd07222
Aligned: 11 rows
Threshold Bit Score: 378.597
Threshold Setting Gi: 170576049
Created: 12-Feb-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
active sitenucleophile
Feature 1:active site [active site]
Evidence:
  • Comment:Based on the crystal structure of semet patatin (1OXW)
  • Comment:catalytic dyad is formed by Ser and Asp
  • Comment:oxyanion hole is formed by two Gly and one Arg

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1              ## #                            #                                         
P41247         5 NLSFAACGFLGIYHLGAASALCRHGKKLVKdVKAFAGASAGSLVASVLLTAPEKIEECnqft------------------ 66  human
NP_001124212   5 NLSFASCGFLGIYHLGAAAALYRHGKKLLKvVKDFAGASAGSLAATVLLAVPENIEKCqqft------------------ 66  chicken
NP_001073832   5 NLSFAACGFLGIYHLGAASALYNHGRKLLKdVKACAGASAGSLVASVLLTAPQKIEECnkfi------------------ 66  cattle
CAG06632       1 NLSFAAAGFLGIYHVGAAEAFLRHGDKLLGsLGGCAGASAGAMVAAVMVTAPDRLQMTkgfi------------------ 62  spotted green p...
AAI53515       4 NVSFAAAGFLGAYHLGVAKALLKHGDKLLSsLKACAGASAGALVAAMIITAPDKLQHCkeft------------------ 65  zebrafish
NP_001088835   5 NLSFSAAGFLGIYHLGAASALLKHGPKMVKrVKCFAGASAGSLVATVLLTAPDKIKESkefl------------------ 66  African clawed ...
XP_001365352   5 NLSFASCGFLGIYHLGVASALYKHGKQLLKvVKAFAGASGGSLVATILLTAPEKIEECneft------------------ 66  gray short-tail...
XP_343791      5 HLSFSSCGFLGIYHLGAATVLSKRGRGLLCnVTGFAGASAGALVATLLLTAPERIEACtrft------------------ 66  Norway rat
NP_497474     96 CLSFGGCGFLGSYQFGAAKMIFDHGKKLMKrVERYSGCSSGSLVAAMFIFNPEKLVFLvsfrktkgrlplfslfllnfrn 175 nematode
XP_001893484   9 ALSFSGCGFLGVYHFGVLKGLNRDGKALMKrVKRCAGASAGALAAALWTFQPDDAEKGfndv------------------ 70  agent of lympha...
NP_505749     21 ALSFSGSGFLGAYNFGAAKRLMQEKKTIGEkVDRFAGASAGSLVAAILALAPEKLDAAidtl------------------ 82  nematode
Feature 1                                                                                        
P41247        67 -------------ykfAEEIRRQSFGAVTPGYDFMARLRSGMESILPPSAHELaqNRLHVSITNAKTR-ENHLVSTFSSR 132 human
NP_001124212  67 -------------yefAEEVRKLDFGAVTPGYDFMKRLREGIESILPSNAHEIaeNRLYVSVTNVRNG-KNYLFSNFASR 132 chicken
NP_001073832  67 -------------ydfAEEIRRQSFGALTPGYDFMARLRSGVESILPTNAHELahGRLHVSITNTRTR-RNCLVSSFPSR 132 cattle
CAG06632      63 -------------selAESVRHRQLGAVVPGSSLMIRLQQLMEVVLPADAHCLanDRLHVSITNVKSG-KNHLVSRFSSR 128 spotted green p...
AAI53515      66 -------------yrfASNVRSQRFGAVTPGYDFMLELREGIEQILPPSAHQLanERLHVSITHSKTH-KNSMVSSFTSR 131 zebrafish
NP_001088835  67 -------------yafSEDVRKQKVGAMTPTYDFMKNLRGGIESILPANAHEIaeHRLYVSITNAKSR-KNCLVSHFASR 132 African clawed ...
XP_001365352  67 -------------ynfAEEIRKQYFGAITPGYDFMARLRGGMETILPLNAHEIadTRLYVSITNVKTR-ENNLVSRFPSR 132 gray short-tail...
XP_343791     67 -------------fafAEEVRMQALGPLTPGYDFMARLRGGIDEILPQHAHEL--ARERLHVSVTSAVgQNYLVSNFTCR 131 Norway rat
NP_497474    176 lcilsiseaveeiykmADEVNDKTLGAMSPGFVISDRLRKVVEKFLPDDVAKAn-DLLFVSVTKLKTW-KNELISNFESK 253 nematode
XP_001893484  71 -------------ikmATEIHSLRFGALSPDFALHRSLQKIVDFYIPEDISNAq-DKLYISLTDQKKN-VNRLISKFTSR 135 agent of lympha...
NP_505749     83 -------------ysmADHVHAQRFGAMTPGYYLNEQLVTIIDDFLPTDIANAq-GRLHISITKLKKW-ENIMINKFDSR 147 nematode
Feature 1                                         #                                              
P41247       133 EDLIKVLLASSFVPIYAGl---KLVEYKGQKWVDGGLTNALPILPvGRTVTISPFSGRLDISPQDkgqldl----yvnia 205 human
NP_001124212 133 EDLIKVLLASSFVPVYAGm---KPVEYKGEKWVDGGITNGLPILPfGRTITISPFSGRLDICPQDkgrvdl----yvkfa 205 chicken
NP_001073832 133 EDLVKVLLASSFLPIYAGl---KPVEYKGQRWVDGGFTNSLPVLPvGRTVTISPFSGRLDISPQDkgrlhf----yvsit 205 cattle
CAG06632     129 DELITALLASSYLPVYAGl---KPVEFRGQKWIDGGFTDSLPVLPvGRTITVSPFAGVQDVCPLHrgqfsa----rfrla 201 spotted green p...
AAI53515     132 EDLIKVLLASCFVPVYAGv---KPVEFQGQKWIDGGFTDSLPILPvGRTITVSPFSGPQDISPEHkgkknl----hlrla 204 zebrafish
NP_001088835 133 EELIKVLLASSYVPLYAGi---KAIDYKGEKWFDGGFTDSLPLLPtGRTITVSPFSGRIDICPQDkthwdl----yvtfa 205 African clawed ...
XP_001365352 133 NDLIKVLLASSFVPVYAGl---KAVEYKGQKWVDGGLTNGLPILPvGRTVTVSPFSGRLDICPEDkgqmdi----yinma 205 gray short-tail...
XP_343791    132 DNLITVLLASCFIPFYAGl---KPMDCAGQLCVDGGLTNSLPVLPtGRTVTFSPFSGRADVSPRDlgwpgi----yvrva 204 Norway rat
NP_497474    254 IDLIDCLMASCYHPMYSSglngKAPILRGEAYIDGGYSNMIPEFLdMRTVTVSAFAGDADICPVEksalfnd--fmfaff 331 nematode
XP_001893484 136 NYLIDSLLASCYIPFYSGs---SPPVIDGDQYIDGGFTNNLPVFEeLPTITISPFSGSAIIAPNDydslrpfrewrlrvg 212 agent of lympha...
NP_505749    148 DHLISCLLASCYIPMYSMgykgVPPIINQEECIDGGMTNNLPTFPdVLTITCSPFSSQADICPDDpstwn------iefg 221 nematode
Feature 1                                                                   
P41247       206 kQDIMLSLANLVRLNQALFPPSkr-----------kMESLYQc---GFDDTVKFLLKEN 250 human
NP_001124212 206 kQDIMLSLANLVRFNQAMFPPNqe-----------kMESLYQn---GFDDAVHFLLKEN 250 chicken
NP_001073832 206 nQEVLLSVANLVRLNRALFPPSrr-----------tMESLYQr---GFDDASRFLVKEN 250 cattle
CAG06632     202 nMSVMLSADNLRRLHQSFFPPPpqlhavlvrgrfqrHREIPEerglGELTASWNLRESV 260 spotted green pufferfish
AAI53515     205 nMSIVFSKENIIRLNQALFPPPlp-----------rLEALEQe---GYQDALRFLKKEK 249 zebrafish
NP_001088835 206 kHSLLLSAANVRRLNQALFPPRqe-----------kMETIFQd---GYKDAVNFLQLKN 250 African clawed frog
XP_001365352 206 nQDIMLSRTNLVRLNQALFPPTqr-----------kMKLLYQn---GFDDATKFLLKEN 250 gray short-tailed opossum
XP_343791    205 kQDVMVSMANLVRVQQALFPPSrg-----------mMEAIYGm---GMTDTVRFLRRER 249 Norway rat
NP_497474    332 nQNMKLTLSNMKRVTNALFPPTra-----------iLQEYFNa---GARDAEKLLKDSG 376 nematode
XP_001893484 213 tQELKVNVQNMIRGAQALFPPNvd-----------vLKSYYEm---GQRDAMRFLLGVG 257 agent of lymphatic filariasis
NP_505749    222 kQIFKASRRNLYRGARALFPPNrf-----------iLKQYYEm---GISDADIFIKKNL 266 nematode

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