Conserved Protein Domain Family
Pat_PNPLA3

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cd07221: Pat_PNPLA3 
Patatin-like phospholipase domain containing protein 3
PNPLA3 is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes and is an indicator of the nutritional state. PNPLA3 is also known as adiponutrin (ADPN) or iPLA2-epsilon. Human adiponutrins are bound to the cell membrane of adipocytes and show transacylase, TG hydrolase, and PLA2 activity. This family includes patatin-like proteins: ADPN (adiponutrin) from mammals, PNPLA3 (Patatin-like phospholipase domain-containing protein 3), and iPLA2-epsilon (Calcium-independent phospholipase A2) from Homo sapiens.
Statistics
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PSSM-Id: 132860
View PSSM: cd07221
Aligned: 9 rows
Threshold Bit Score: 507.392
Threshold Setting Gi: 194680931
Created: 12-Feb-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
active sitenucleophile
Feature 1:active site [active site]
Evidence:
  • Comment:Based on the crystal structure of semet patatin (1OXW)
  • Comment:catalytic dyad is formed by Ser and Asp
  • Comment:oxyanion hole is formed by two Gly and one Arg

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1               ## #                            #                                        
CAG30362       8 WSLSFAGCGFLGFYHVGATRCLSEHAPHLLRDARmLFGASAGALHCVGVLSGiPLEQTLQVLSDLvRKARSRNIGIFHPS 87  human
EDL04458       8 WSLSFAGCGFLGFYHVGATLCLSERAPHLLRDARtFFGCSAGALHAVTFVCSlPLGRIMEILMDLvRKARSRNIGTLHPF 87  house mouse
EDL04459       8 WSLSFAGCGFLGFYHVGATLCLSERAPHLLRDARtFFGCSAGALHAVTFVCSlPLGRIMEILMDLvRKARSRNIGTLHPF 87  house mouse
XP_001367550   8 WSFSFAGCGFMGFYYLGVTRCLNEHAPQLVHNAPkMLGASAGALHCATVLCGlTLDHRLQILMDLcRSARKRNLGVLHPS 87  gray short-tail...
Q91WW7         8 WSLSFAGCGFLGFYHVGATLCLSERAPHLLRDARtFFGCSAGALHAVTFVCSlPLGRIMEILMDLvRKARSRNIGTLHPF 87  house mouse
ABQ52661       1 WSLSFVGCGFLGFYHVGVTRCLCERAPHLIRHAHrFFGTSAGALHCAVFLSGtSLDQTLEMLMGLvRSARSRSLSILHPS 80  pig
XP_001488012   8 WSMSFSGCGFLGFYHVGVTCCLGERAPHLLRDARmFLGASGGALHVVSFLSGmPLELRVQILIKIsRSARSRNIGIFHPS 87  horse
XP_851702    116 WSLSFSGCGFLGFYHVGVTRCLSERAPHLVHDARmLFGSSARALHCVTMLSGiPLEIIIQVLMDIsQKARSRNIGILHPS 195 dog
XP_001253781   8 WSLSFAGCGFLCVYYVGVTRCLSEHAPHLLRQVQkFFGASSGALYCAFFLSGiPLDQTLQILMDLtRSARSQKFGIVHPG 87  cattle
Feature 1                                                                                      # 
CAG30362      88 FNLSKfLRQGLCKCLPANVHQLISGKIGISLTRVSDGENVLVSDFRSKDEVVDALVCSCFIPFYSGLIPPSFRGVRYVDG 167 human
EDL04458      88 FNINKcIRDGLQESLPDNVHQVISGKVHISLTRVSDGENVLVSEFHSKDEVVDALVCSCFIPLFSGLIPPSFRGERYVDG 167 house mouse
EDL04459      88 FNINKcIRDGLQESLPDNVHQVISGKVHISLTRVSDGENVLVSEFHSKDEVVDALVCSCFIPLFSGLIPPSFRGERYVDG 167 house mouse
XP_001367550  88 FHMSQhLRDGLNKHLPDNAHQLVSGKMVVSLTRVSDGKNVLVSDFDSKEEVIDALVCSCFIPFYCGLIPPSFRGVRYIDG 167 gray short-tail...
Q91WW7        88 FNINKcIRDGLQESLPDNVHQVISGKVHISLTRVSDGENVLVSEFHSKDEVVDALVCSCFIPLFSGLIPPSFRGERYVDG 167 house mouse
ABQ52661      81 FNLSKrLREGLRRILPDNAHQLLSGKLCISLTRVSDGKNVLVSDFRSKEEVLDALLCSSFIPLVSGFIPPSFRGERYVDG 160 pig
XP_001488012  88 FNLDRqIREDLHRHLPGNVHQLISGKICISLTRVSDGENVMVSDFRSKDEVVDALMCSCFIPFLSGLMPPSFRGVRYVDG 167 horse
XP_851702    196 FSLGRnLQESLQRHLPDNVHMLISGKTCISLTRVSDGENVLVSEFQSKEEVVDALLCSSFIPFFSGIIPPSFRGVRYMDG 275 dog
XP_001253781  88 FSLSKhTRDGLQRHLPDNVHQLVSGKMVVSLTRVSDGKNVLVSDFHSKDEVVDALCCSCYVPFICGWIPPSFRGVRYVDG 167 cattle
Feature 1                                                                                        
CAG30362     168 GVSDNVPFIDAKTTITVSPFYGEYDICPKVKSTNFlHVDITKLSLRlCTGNLYLLSRAFVPPDLKVLGEICLRGYLDAFR 247 human
EDL04458     168 GVSDNVPVLDAKTTITVSPFYGEHDICPKVKSTNFfHVNITNLSLRlCTGNLQLLTRALFPSDVKVMGELCYQGYLDAFR 247 house mouse
EDL04459     168 GVSDNVPVLDAKTTITVSPFYGEHDICPKVKSTNFfHVNITNLSLRlCTGNLQLLTRALFPSDVKVMGELCYQGYLDAFR 247 house mouse
XP_001367550 168 GASSNSPLIDAGTTITVSPFYGEYDICPKVISTNFfYVAVTDFSFRfCSANVYLVTRALFPPEPKVLGEICLRGYLDAFR 247 gray short-tail...
Q91WW7       168 GVSDNVPVLDAKTTITVSPFYGEHDICPKVKSTNFfHVNITNLSLRlCTGNLQLLTRALFPSDVKVMGELCYQGYLDAFR 247 house mouse
ABQ52661     161 GVSDNVPFFDSKTTITVSPFYGENDICPKVKSTNFlHVDFTKLNLRlCSENIYLISRALFPPDVKVLGEICLRGYLDAVR 240 pig
XP_001488012 168 GLSNNIPFFDAKTTITVSPFYGEFDICPKATSTNFlYMDFARLSLRlCSENVYLVIRALFPPDLKVLGEICLRGYLDAVR 247 horse
XP_851702    276 GASDNVPFFDAKTTITVSPFYGEYDICPKVKSTNFlQVDLTKLNLRlCSENAYLLMRALFPPDLKVLGEICLRGYLDAFR 355 dog
XP_001253781 168 GVTDIMPFVDSKKTITVSPFYGESDICPKVKSTFFlNEGFTKLNMQfCTENLYLMFRSLLMLDVKMLGELCLQGYVDALR 247 cattle
Feature 1                    
CAG30362     248 FLEEKGICNRPQ 259 human
EDL04458     248 FLEENGICNGPQ 259 house mouse
EDL04459     248 FLEENGICNGPQ 259 house mouse
XP_001367550 248 FLEEKGICNPSP 259 gray short-tailed opossum
Q91WW7       248 FLEENGICNGPQ 259 house mouse
ABQ52661     241 SLEENGICDRPH 252 pig
XP_001488012 248 FLEENGICDRPH 259 horse
XP_851702    356 FLEENGICNRLQ 367 dog
XP_001253781 248 FLEKNGIREGPH 259 cattle

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