Conserved Protein Domain Family
Pat_PNPLA9

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cd07212: Pat_PNPLA9 
Patatin-like phospholipase domain containing protein 9
PNPLA9 is a Ca-independent phospholipase that catalyzes the hydrolysis of glycerophospholipids at the sn-2 position. PNPLA9 is also known as PLA2G6 (phospholipase A2 group VI) or iPLA2beta. PLA2G6 is stimulated by ATP and inhibited by bromoenol lactone (BEL). In humans, PNPLA9 in expressed ubiquitously and is involved in signal transduction, cell proliferation, and apoptotic cell death. Mutations in human PLA2G6 leads to infantile neuroaxonal dystrophy (INAD) and idiopathic neurodegeneration with brain iron accumulation (NBIA). This family includes PLA2G6 from Homo sapiens and Rattus norvegicus.
Statistics
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PSSM-Id: 132851
View PSSM: cd07212
Aligned: 16 rows
Threshold Bit Score: 434.837
Threshold Setting Gi: 13384434
Created: 10-Feb-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
active sitenucleophile
Feature 1:active site [active site]
Evidence:
  • Comment:Based on the crystal structure of semet patatin (1OXW)
  • Comment:catalytic dyad is formed by Ser and Asp
  • Comment:oxyanion hole is formed by two Gly and one Arg

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1               ## #                             #                                        
O60733        480 LLCLDGGGVKGLIIIQLLIAIEKASGvatkdlFDWVAGTSTGGILALAILh-SKSMAYMRGMYFRMKDEVFRGS----RP 554  human
3877169       747 LISMDGGGIRGLVIIQTLIAIEERLGddifkyFDWSAGTSTGSLIMAGLAt-GKSLREMQQTYLLLKDRVFDGIm---PP 822  Caenorhabditi...
XP_001636774  210 ILTLDGGGIRGLVLTQLLSAIEEVSGqsinslFDWISGTSIGGIIALALVh-GKSVSFCQGFLFRMKDKVFKGP----RP 284  starlet sea a...
ABC86277      563 LLCLDGGGIRGLVLVQMLLEIEKLSRtpiihmFDWIAGTSTGGILALALGc-GKTMRQCVGLYLRMKEQCFVGS----RP 637  fruit fly
13384434      171 LLALDGGGIRAVITIQMLIHIDYLLGgklvekLDDIAGTSCGGVITLLLStnNRNIEETRKLLLDMRDRVFIRGadkaVP 250  Caenorhabditi...
CAK05383      430 LLCLDGGGIKGLVLIQLLIALEKEAGrpirelFDWVSGTSTGGILALAIVh-GKSMEYLRCLYFRMKEQVFKGS----RP 504  zebrafish
XP_001899472  667 LLSLDGGGIRGLVIIQMLLELEKMMGepffsyFDMVAGTSTGGIIAAALAl-GKTLRDCQQIYLRLKDLIFDSWa---RP 742  agent of lymp...
XP_781913     418 VLCLDGGGIKGLILTQMLAAIEKASGkkivemFDWIVGTSTGGILALALSq-GFSVEECRKLYMALKDEVFTGS----RP 492  purple urchin
XP_002119484  439 VLCLDGGGVRGLVLSQILMAIERETGkqcrdlFDWISGTSTGGFLAMALLm-GKSAIEAQRLYFRFKDKVFVGS----RP 513  Ciona intesti...
3880573       693 VLGLDGGGIRGLVTVQMLICLEAFLDrplidyFDWIGATSTGCYIMSTMMt-GGSLRKAQRYYLMFKDQLFDSWt---RP 768  Caenorhabditi...
Feature 1                                                                                         
O60733        555 YESGPLEEFLKREFGEh--tKMTDVRKPKVMLTGTLSDRqPAELHLFRNYDAPetvreprfnq-----------nvnlrp 621  human
3877169       823 YDTVQLEKFIQDQFGTg---TVWEIPYPRLMISAVNSEKlPVRLEMARNYKPAkdva----------------------- 876  Caenorhabditi...
XP_001636774  285 YDTEPLEKLLQETFGEn--tKMTAVTHPKTLVTAVLADRrPATLYFFRNYNMPedlepirkn-------------npfpp 349  starlet sea a...
ABC86277      638 YNSEFFESILKDNLGEf--nVMTDIKHPKIMVTGVMADRkPVDLHLFRNYTSAsdilgivtpi-----------nnrrip 704  fruit fly
13384434      251 KYSSNGMEYIARHVTTwedsKMSSIKRHRAIVTVADTRMvPPQLLLFRSYRPEmpeeace-----------------hyk 313  Caenorhabditi...
CAK05383      505 YESGPLEEFLKNEFGEn--tKMTDVTHPRVMVTSVLADRhPGELHLFRNYDPPalqrdppyks-----------tatfqp 571  zebrafish
XP_001899472  743 YNTSLLELFIQAEVGTd--mTLASVPWPKMILTTVRADCfPVRLELMRNFRLPlsdeens-----------------slg 803  agent of lymp...
XP_781913     493 YNSDKLESFLKDTFGAe--tTMDKYTYPRILVSGTLGDRsPPALHLFRNYDAPetssawiaan-----------qepflp 559  purple urchin
XP_002119484  514 YNSEPMEDFLKKEFGEdt-tMESLQHGPRLLITAALADRkPIHLHLFRNYNLTdpiskslktksfskklsdaemkkltcd 592  Ciona intesti...
3880573       769 YDTKTLETFIQRAFGAd--rLMGDIKYPRFFCTTVRADTfPVQLELLRNYRLPisekenn-----------------dlg 829  Caenorhabditi...
Feature 1                                        #                                                
O60733        622 paqPSDQLVWRAARSSGAAPTYFRPn-GRFLDGGLLANNPTLDAMTEIHEYNqdlirkg------qankvkKLSIVVSLG 694  human
3877169       877 petPKEMPLWMALRRSTAAPVLFKPseDRYIDGGIISNNPALDLMSEVHAYNrelqlsg------rksdavQMNVLVSFG 950  Caenorhabditi...
XP_001636774  350 ppvPAVQQVWRAARGSGAAPTFFRAm-GRFLDGGLIANNPTLDVLSEVHKYYcvhephn-----kkgpgnsNIGLVVSLG 423  starlet sea a...
ABC86277      705 ppqPSEQLVWRAARATGAAPSYFRAf-GRFLDGGLIANNPTLDAMTEIHEYNmalrsag------reseaiPVSVVMSLG 777  fruit fly
13384434      314 fldPTKVELWKTLRCTTAAPYFFESf-NGLSDGGLIANNPTLALISDFFLTNkleksfakssserenrgnwKIGCVISLG 392  Caenorhabditi...
CAK05383      572 ltvPQEQLVWRAARSSGAAPTYFRPm-GRFLDGGLLANNPTLDAMTEIHQFNkalkaqg------rdedvtRLGVVVSLG 644  zebrafish
XP_001899472  804 yadPADTLLWKALRRTSAAPTYFSSvdNRYIDGGIISNNPALELLSELAFWNttnhflt-----ssennaiQLGCLLSVG 878  agent of lymp...
XP_781913     560 vlkPSEQLMWRAARSSGAAPTYFRPm-GRFLDGGLIANNPTLDALTEIQEYYmykksq--------gepvrKIGAVVSLG 630  purple urchin
XP_002119484  593 atsSLKQLLWEAARSSGAAPTYFRPm-GPYLDGGLVANNPTLDTLTEIHKYNkelvrt-------gagdykKIGLVLSIG 664  Ciona intesti...
3880573       830 ftdPNELTIWKATRRSSAAPTYFSAseGKFIDGGMISNNPVLDLMSDIGFYNttcqkmr------ipekmvDMGCVLSVG 903  Caenorhabditi...
Feature 1                                                                                         
O60733        695 TGRSPQVPVtcvdvfrpsnp---welaktvfgaKELGKMVVDCCTDPDGRAVDRARAWCEMVGIQYFRLNPQLGTDImLD 771  human
3877169       951 TGQIPSTVIetlsidsns-------plqsiktiKNLAAMFIDQATASEGAPVARSRQWADSLEIPFFRFSAPLSKNIfLS 1023 Caenorhabditi...
XP_001636774  424 TGVPPPEHVptfdvfkpetm---wdatnvllgaRALGLLMVDQATATNGAVVDRARAWCEMIGSQYFRFSSPMSADVgLD 500  starlet sea a...
ABC86277      778 TGHIPVTELkdidvfrpesi---wdtaklaygiSTIGNLLVDQATCSDGRVVDRARAWCSTIGIPYFRFNPQLSEDIaMD 854  fruit fly
13384434      393 TGVFPTEKI------------------------DGIDLIVAHACTASNGQPVRYAREWCHSINAPYFRFSPHLSQGIsLD 448  Caenorhabditi...
CAK05383      645 TGKPPQVAVnsvdvfrpsnp---ielaktfvgvKELGKMLVDCCTDSDGCAVDRARAWCEMADINYHRLSPQLSQEVmLD 721  zebrafish
XP_001899472  879 TGAIPTMPLstsnleiss------npyssavaiKNLGVILVEQVTATEGAPVERARSWCHNMNVPFFRLSAPLHKDIpMD 952  agent of lymp...
XP_781913     631 TGLTALKPIahveimrpnsavdllsaakslaagANLIDIMVEQVTESRMRAVDRARAWCFSIGTPFFRFSPPLSQEIsMD 710  purple urchin
XP_002119484  665 TGQMKTTTArsldlnwsssp---ialmntalagSELAQMMVDVCCQSNDYVVERAKAWCETMDASYFRLNPFMEDEVqLN 741  Ciona intesti...
3880573       904 TGITPICPVdpsvfemnd-------lfgmlrgmKNLSLVVIDQATATEGAPITRSRTWCHSLGVPYYRLNAPIFKDViLD 976  Caenorhabditi...
Feature 1                               
O60733        772 EVSDTVLVNALWETEVYIYEHR 793  human
3877169      1024 STSDLDVCTMMWDSFIYCRKHR 1045 Caenorhabditis elegans
XP_001636774  501 ETDDRILVKMLWETRVYILQNL 522  starlet sea anemone
ABC86277      855 EKDDQKLINMLWHTKAYMHANR 876  fruit fly
13384434      449 EIDLEKVMQVMWETEQYVASHR 470  Caenorhabditis elegans
CAK05383      722 EVSDAVLVDMLWETQMYLYEHR 743  zebrafish
XP_001899472  953 TRDDTDIARMMWDCVQYCNTMR 974  agent of lymphatic filariasis
XP_781913     711 ETRDHVLSKMLFDTQCYIQKNK 732  purple urchin
XP_002119484  742 ETNDEILLNLLWDTQVYLQENK 763  Ciona intestinalis
3880573       977 TNDDYDLAKIMWDSVVYSHTHK 998  Caenorhabditis elegans

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